Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T423845-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 |
Hepatitis C virus (HCV) protease NS3/4A inhibitor
Synonyms | Telaprevir | 402957-28-2 | VX-950 | Incivek | Incivo | Telaprevir (VX-950) | MP-424 | VX 950 | Telavic | LY-570310 | S-Telaprevir | MP 424 | VRT 111950 | VRT-111950 | VX950 cpd | LY 570310 | UNII-655M5O3W0U | CHEBI:68595 | HSDB 8125 | 655M5O3W0U | CHEMBL231813 | (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclo |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Hepatitis C virus (HCV) protease NS3/4A inhibitor. Orally bioavailable. Inhibits HCV RNA replicationin vitro(IC50= 0.35 μM). Also used in Stabilizable Polypeptide Linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expressio |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM. |
ALogP | 4.2 |
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IUPAC Name | (3S,3aS,6aR)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide |
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INCHI | InChI=1S/C36H53N7O6/c1-5-10-25(29(44)34(48)39-23-15-16-23)40-33(47)28-24-14-9-13-22(24)20-43(28)35(49)30(36(2,3)4)42-32(46)27(21-11-7-6-8-12-21)41-31(45)26-19-37-17-18-38-26/h17-19,21-25,27-28,30H,5-16,20H2,1-4H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t22-,24-,25-,27-,28-,30+/m0/s1 |
InChi Key | BBAWEDCPNXPBQM-GDEBMMAJSA-N |
Canonical SMILES | CCCC(C(=O)C(=O)NC1CC1)NC(=O)C2C3CCCC3CN2C(=O)C(C(C)(C)C)NC(=O)C(C4CCCCC4)NC(=O)C5=NC=CN=C5 |
Isomeric SMILES | CCC[C@@H](C(=O)C(=O)NC1CC1)NC(=O)[C@@H]2[C@H]3CCC[C@H]3CN2C(=O)[C@H](C(C)(C)C)NC(=O)[C@H](C4CCCCC4)NC(=O)C5=NC=CN=C5 |
PubChem CID | 3010818 |
Molecular Weight | 679.85 |
Enter Lot Number to search for COA:
Melt Point(°C) | 221-224°C |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |