Grouped product items

SKU

Size

Availability

Price

Qty

T614373-5mg

5mg

Available within 8-12 weeks(?)

$674.90

T614373-25mg

25mg

Available within 8-12 weeks(?)

$2,020.90

Basic Description

Synonyms	DTXSID10873383 \| N(3'')-(2-(decylamino)ethyl)-29-(((phosphonomethyl)amino)methyl)vancomycin \| SCHEMBL8287015 \| telavancine \| Televancin \| Vancomycin, N3''-(2-(decylamino)ethyl)-29-(((phosphonomethyl)amino)methyl)- \| (1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-a
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(Human)

ALB Tchem Serum albumin (2651 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

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HK-2 (249 Activities)

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L02 (4864 Activities)

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Associated Targets(non-human)

Streptococcus sanguinis (314 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Enterococcus (1748 Activities)

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Collinsella aerofaciens (60 Activities)

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Streptococcus viridans (303 Activities)

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Eggerthella lenta (139 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Bacteroides fragilis (1445 Activities)

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Bacteroides thetaiotaomicron (562 Activities)

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Parabacteroides distasonis (282 Activities)

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Fusobacterium mortiferum (179 Activities)

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Fusobacterium varium (184 Activities)

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Peptoniphilus asaccharolyticus (368 Activities)

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Peptostreptococcus anaerobius (347 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Staphylococcus haemolyticus (1695 Activities)

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Staphylococcus hominis (482 Activities)

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Escherichia coli (133304 Activities)

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Phocaeicola vulgatus (440 Activities)

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Hoylesella loescheii (67 Activities)

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Finegoldia magna (323 Activities)

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Staphylococcus (1598 Activities)

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Staphylococcus simulans (400 Activities)

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Staphylococcus warneri (476 Activities)

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Streptococcus sp. (212 Activities)

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Streptococcus agalactiae (1777 Activities)

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Streptococcus pyogenes (16140 Activities)

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Enterococcus faecium (13803 Activities)

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Paraclostridium bifermentans (60 Activities)

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Clostridium butyricum (54 Activities)

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Clostridioides difficile (2968 Activities)

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Clostridium perfringens (1165 Activities)

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Clostridium sporogenes (139 Activities)

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Thomasclavelia ramosa (78 Activities)

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Actinomyces naeslundii (215 Activities)

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Enterococcus faecalis (29875 Activities)

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Paeniclostridium sordellii (66 Activities)

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Clostridium tertium (174 Activities)

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Oryctolagus cuniculus (11301 Activities)

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Mus musculus (284745 Activities)

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Staphylococcus saprophyticus (562 Activities)

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Staphylococcus capitis (242 Activities)

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Streptococcus mitis (390 Activities)

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Bacteroides ovatus (282 Activities)

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Prevotella bivia (313 Activities)

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Prevotella buccae (219 Activities)

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Prevotella disiens (96 Activities)

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Prevotella melaninogenica (262 Activities)

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Hoylesella oralis (105 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(1S,2R,18R,19R,22S,25R,28R,40S)-22-(2-amino-2-oxoethyl)-5,15-dichloro-48-[(2S,3R,4S,5S,6R)-3-[(2S,4S,5S,6S)-4-[2-(decylamino)ethylamino]-5-hydroxy-4,6-dimethyloxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,18,32,35,37-pentahydroxy-19-[[(2R)-4-methyl-2-(methylamino)pentanoyl]amino]-20,23,26,42,44-pentaoxo-36-[(phosphonomethylamino)methyl]-7,13-dioxa-21,24,27,41,43-pentazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylic acid
INCHI	InChI=1S/C80H106Cl2N11O27P/c1-7-8-9-10-11-12-13-14-21-85-22-23-87-80(5)32-57(115-37(4)71(80)103)119-70-68(102)67(101)55(34-94)118-79(70)120-69-53-28-41-29-54(69)117-52-20-17-40(27-46(52)82)65(99)63-77(109)91-61(78(110)111)43-30-50(96)44(33-86-35-121(112,113)114)66(100)58(43)42-25-38(15-18-49(42)95)59(74(106)93-63)90-75(107)60(41)89-73(105)48(31-56(83)97)88-76(108)62(92-72(104)47(84-6)24-36(2)3)64(98)39-16-19-51(116-53)45(81)26-39/h15-20,25-30,36-37,47-48,55,57,59-65,67-68,70-71,79,84-87,94-96,98-103H,7-14,21-24,31-35H2,1-6H3,(H2,83,97)(H,88,108)(H,89,105)(H,90,107)(H,91,109)(H,92,104)(H,93,106)(H,110,111)(H2,112,113,114)/t37-,47+,48-,55+,57-,59+,60+,61-,62+,63-,64+,65+,67+,68-,70+,71+,79-,80-/m0/s1
InChi Key	ONUMZHGUFYIKPM-MXNFEBESSA-N
Canonical SMILES	CCCCCCCCCCNCCNC1(CC(OC(C1O)C)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C(=C(C=C9C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)O)CNCP(=O)(O)O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)C
Isomeric SMILES	CCCCCCCCCCNCCN[C@]1(C[C@@H](O[C@H]([C@H]1O)C)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C(=C(C=C9[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)O)CNCP(=O)(O)O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)C
Alternate CAS	372151-71-8
PubChem CID	3081362
MeSH Entry Terms	TD 6424;TD-6424;TD6424;telavancin;telavancin hydrochloride;Vibativ

Database links

PubChem CID	3081362
CAS Registry No.	372151-71-8
ChEMBL Ligand	CHEMBL507870
DrugBank Ligand	DB06402
DrugCentral Ligand	4116
Antibiotic DB	1972

Certificates

Certificate of Analysis(COA)

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Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yechang Guo, Shaofeng Wang, Peiyue Li, Pan Zhang, Wei Wang. (2023) Rapid Colloidal Gold Immunoassay for Pharmacokinetic Evaluation of Vancomycin in the Cerebrospinal Fluid and Plasma of Beagle Dogs. SENSORS, 23 (21): (8978). [PMID:37960677]
2. Guiqiu Li, Ying Wei, Yan Guo, Hui Gong, Jie Lian, Guangjian Xu, Bing Bai, Zhijian Yu, Qiwen Deng. (2022) Omadacycline Efficacy against Streptococcus Agalactiae Isolated in China: Correlation between Resistance and Virulence Gene and Biofilm Formation. Computational Intelligence and Neuroscience, 2022 (7636983). [PMID:35510054]

References

1. Singh MP, Petersen PJ, Weiss WJ, Kong F, Greenstein M. (2000) Saccharomicins, novel heptadecaglycoside antibiotics produced by Saccharothrix espanaensis: antibacterial and mechanistic activities.. Antimicrob Agents Chemother, 44 (8): (2154-9). [PMID:10898690]
2. Jansen WT, Verel A, Verhoef J, Milatovic D. (2007) In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe.. Antimicrob Agents Chemother, 51 (9): (3420-4). [PMID:17606689]
3. Hegde SS, Reyes N, Wiens T, Vanasse N, Skinner R, McCullough J, Kaniga K, Pace J, Thomas R, Shaw JP et al.. (2004) Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteria.. Antimicrob Agents Chemother, 48 (8): (3043-50). [PMID:15273119]
4. Mendes RE, Farrell DJ, Sader HS, Streit JM, Jones RN. (2015) Update of the telavancin activity in vitro tested against a worldwide collection of Gram-positive clinical isolates (2013), when applying the revised susceptibility testing method.. Diagn Microbiol Infect Dis, 81 (4): (275-9). [PMID:25618421]
5. A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.. Biochim Biophys Acta, 1812 (8): (982-94). [PMID:21193033]
6. Yechang Guo, Shaofeng Wang, Peiyue Li, Pan Zhang, Wei Wang. (2023) Rapid Colloidal Gold Immunoassay for Pharmacokinetic Evaluation of Vancomycin in the Cerebrospinal Fluid and Plasma of Beagle Dogs. SENSORS, 23 (21): (8978). [PMID:37960677]
7. Guiqiu Li, Ying Wei, Yan Guo, Hui Gong, Jie Lian, Guangjian Xu, Bing Bai, Zhijian Yu, Qiwen Deng. (2022) Omadacycline Efficacy against Streptococcus Agalactiae Isolated in China: Correlation between Resistance and Virulence Gene and Biofilm Formation. Computational Intelligence and Neuroscience, 2022 (7636983). [PMID:35510054]

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telavancin , CAS No.372151-71-8

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

Citations of This Product

References

Solution Calculators

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Dilution Calculator

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SKU	Size	Availability	Price	Qty
T614373-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$674.90
T614373-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,020.90