Telbivudine - ≥98%, high purity , DNA polymerase/reverse transcriptase inhibitor, CAS No.3424-98-4, DNA polymerase/reverse transcriptase inhibitor

  • ≥98%
Item Number
T129668
Grouped product items
SKUSizeAvailabilityPrice Qty
T129668-5mg
5mg
In stock
$21.90
T129668-25mg
25mg
In stock
$90.90
T129668-100mg
100mg
In stock
$302.90
T129668-500mg
500mg
In stock
$1,363.90

Antiviral agent

Basic Description

SynonymsTelbivudine | 3424-98-4 | 2'-Deoxy-L-thymidine | Epavudine | L-Thymidine | beta-L-Thymidine | L-dT | Telbivudin | Sebivo | Tyzeka | L-Deoxythymidine | NV-02B | LDT600 | beta-L-2'-Deoxythymidine | LdT | LDT-600 | NV 02B | CHEBI:63624 | UNII-2OC4HKD3SF | 2OC4HKD3SF | 1-(2-Deoxy-beta-L-erythro-pen
Specifications & Purity≥98%
Biochemical and Physiological MechanismsTelbivudine is a nucleoside analog. A specific inhibitor of hepatitis B virus (HBV) replication. Antiviral.Antiviral agent. Thymidine analog. Shows immunomodulatory effects. Suppresses programmed death ligand 1 expression on T cells. Orally active. Potent
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeINHIBITOR
Mechanism of actionDNA polymerase/reverse transcriptase inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.
A specific hepatitis B virus (HBV) replication inhibitor

Product Properties

ALogP-1.2

Associated Targets(Human)

HDAC6 Tclin Histone deacetylase 6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SCN5A Tclin Sodium channel protein type 5 subunit alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABCC4 Tchem Multidrug resistance-associated protein 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABCB11 Tchem Bile salt export pump (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNQ1 Tclin Potassium voltage-gated channel subfamily KQT member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCND3 Tclin Potassium voltage-gated channel subfamily D member 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCND3 Tclin Voltage-gated potassium channel subunit Kv4.3 (100 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SCN5A Tclin Sodium channel protein type V alpha subunit (3462 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNQ1 Tclin Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) (185 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 2.2.15 (869 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hepatitis B virus (7925 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Woodchuck hepatitis virus (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HBcAg Core antigen (581 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cacna1c Voltage-gated L-type calcium channel (1164 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488188284
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488188284
IUPAC Name 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
INCHI InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
InChi Key IQFYYKKMVGJFEH-CSMHCCOUSA-N
Canonical SMILES CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
Isomeric SMILES CC1=CN(C(=O)NC1=O)[C@@H]2C[C@H]([C@@H](O2)CO)O
WGK Germany 3
RTECS UV9048500
PubChem CID 159269
Molecular Weight 242.23

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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5 results found

Lot NumberCertificate TypeDateItem
D23211576Certificate of AnalysisMar 16, 2023 T129668
D23211583Certificate of AnalysisMar 16, 2023 T129668
D23211602Certificate of AnalysisMar 16, 2023 T129668
D23211605Certificate of AnalysisMar 16, 2023 T129668
D23211611Certificate of AnalysisMar 16, 2023 T129668

Chemical and Physical Properties

SolubilitySoluble in water (48 mg/ml at 25 °C), DMSO (48 mg/ml at 25 °C), and ethanol (2 mg/ml at 25 °C)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
RTECS UV9048500

Related Documents

Solution Calculators