Grouped product items

SKU

Size

Availability

Price

Qty

T614375-5mg

5mg

Available within 8-12 weeks(?)

$1,334.90

T614375-25mg

25mg

Available within 8-12 weeks(?)

$2,001.90

Basic Description

Synonyms	A63004 \| 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinoline-carboxylic acid \| CS-0006360 \| Temafloxacine \| AKOS016844314 \| DTXSID7044132 \| A 62254 \| FT-0631048 \| Tox21_113306 \| (+/-)-1-(2,4-DIFLUOROPHENYL)-6-FLUORO-1,
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Streptococcus pneumoniae (31063 Activities)

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Plasmodium yoelii yoelii (73 Activities)

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Bacteria (550 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Burkholderia cepacia (649 Activities)

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Enterobacter cloacae (7976 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Micrococcus luteus (7463 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Acinetobacter (437 Activities)

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Klebsiella aerogenes (4963 Activities)

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Escherichia coli (133304 Activities)

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Providencia stuartii (425 Activities)

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Streptococcus agalactiae (1777 Activities)

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Streptococcus pyogenes (16140 Activities)

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Enterococcus faecium (13803 Activities)

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Mycolicibacterium fortuitum (1335 Activities)

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Enterococcus faecalis (29875 Activities)

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Mycolicibacterium smegmatis (8003 Activities)

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Plasmodium falciparum (966862 Activities)

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Rattus norvegicus (775804 Activities)

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Streptococcus equinus (217 Activities)

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gyrB DNA gyrase (2092 Activities)

Discover Target: gyrB

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Mycobacterium leprae (477 Activities)

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Glra2 Glycine receptor (1745 Activities)

Discover Target: Glra2

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
INCHI	InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
InChi Key	QKDHBVNJCZBTMR-UHFFFAOYSA-N
Canonical SMILES	CC1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=C(C=C(C=C4)F)F)F
Isomeric SMILES	CC1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=C(C=C(C=C4)F)F)F
Alternate CAS	108319-06-8,105784-61-0 (hydrochloride)
PubChem CID	60021
MeSH Entry Terms	1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(3-methyl-1-piperazinyl)quinoline-3-carboxylic acid, hydrochloride;A 62254;A-62254;temafloxacin;temafloxacin hydrochloride

Database links

PubChem CID	60021
CAS Registry No.	108319-06-8
ChEMBL Ligand	CHEMBL277100
DrugBank Ligand	DB01405
Antibiotic DB	942
DrugCentral Ligand	2584

Certificates

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References

1. Chu DT, Nordeen CW, Hardy DJ, Swanson RN, Giardina WJ, Pernet AG, Plattner JJ. (1991) Synthesis, antibacterial activities, and pharmacological properties of enantiomers of temafloxacin hydrochloride.. J Med Chem, 34 (1): (168-74). [PMID:1846917]
2. Domagala JM, Bridges AJ, Culbertson TP, Gambino L, Hagen SE, Karrick G, Porter K, Sanchez JP, Sesnie JA, Spense FG et al.. (1991) Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.. J Med Chem, 34 (3): (1142-54). [PMID:1848296]

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temafloxacin , CAS No.108319-06-8

Basic Description

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

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Dilution Calculator

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SKU	Size	Availability	Price	Qty
T614375-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
T614375-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90