Temozolomide - ≥98% (HPLC), high purity , DNA inhibitor, CAS No.85622-93-1, DNA inhibitor

Item Number
T127425
Grouped product items
SKUSizeAvailabilityPrice Qty
T127425-250mg
250mg
In stock
$21.90
T127425-500mg
500mg
In stock
$34.90
T127425-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$47.90
T127425-5g
5g
In stock
$142.90
T127425-25g
25g
In stock
$426.90

DNA alkylating/methylating chemotherapeutic agent

Basic Description

Synonyms4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide | CCRG 81045 | NSC 362856 | TMZ | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide | 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one | TZM
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanismsenzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint,
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionDNA inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Temozolomide is a DNA damage inducer.
An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint.

Product Properties

ALogP-1.1

Associated Targets(Human)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCGR Tclin Glucagon receptor (2563 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Htr7 Serotonin 7 (5-HT7) receptor (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TLX-5 (157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C6 (2371 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RG2 (196 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16-F10 (4610 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Blood brain barrier (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GL261 (68 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
INCHI InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChi Key BPEGJWRSRHCHSN-UHFFFAOYSA-N
Canonical SMILES CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
Isomeric SMILES CN1C(=O)N2C=NC(=C2N=N1)C(=O)N
WGK Germany 3
RTECS NJ5927050
PubChem CID 5394
Molecular Weight 194.15
Reaxy-Rn 5547136

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

22 results found

Lot NumberCertificate TypeDateItem
I2412042Certificate of AnalysisSep 21, 2024 T127425
I2412043Certificate of AnalysisSep 18, 2024 T127425
J2410764Certificate of AnalysisSep 04, 2024 T127425
J2410763Certificate of AnalysisSep 04, 2024 T127425
J2410762Certificate of AnalysisSep 04, 2024 T127425
J2410761Certificate of AnalysisSep 04, 2024 T127425
J2227766Certificate of AnalysisAug 15, 2024 T127425
J2227749Certificate of AnalysisAug 15, 2024 T127425
J2227698Certificate of AnalysisAug 12, 2024 T127425
J2227785Certificate of AnalysisAug 12, 2024 T127425
J2227652Certificate of AnalysisAug 12, 2024 T127425
F2217267Certificate of AnalysisApr 02, 2024 T127425
D2408191Certificate of AnalysisMar 22, 2024 T127425
I1817142Certificate of AnalysisFeb 26, 2024 T127425
K2130080Certificate of AnalysisSep 15, 2023 T127425
K2130076Certificate of AnalysisSep 15, 2023 T127425
K2130077Certificate of AnalysisSep 15, 2023 T127425
K2130078Certificate of AnalysisSep 15, 2023 T127425
J2227772Certificate of AnalysisJul 21, 2022 T127425
D2409062Certificate of AnalysisJul 21, 2022 T127425
A2408039Certificate of AnalysisJul 21, 2022 T127425
C2221050Certificate of AnalysisMar 24, 2022 T127425

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Chemical and Physical Properties

SolubilitySoluble in water (5 mg/ml at 25 °C), DMSO (39 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
SensitivityHeat sensitive
Melt Point(°C)206 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H341:Suspected of causing genetic defects

H351:Suspected of causing cancer

H302:Harmful if swallowed

H300:Fatal if swallowed

H372:Causes damage to organs through prolonged or repeated exposure

H360:May damage fertility or the unborn child

H340:May cause genetic defects

H350:May cause cancer

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P281:Use personal protective equipment as required.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS NJ5927050
Reaxy-Rn 5547136
Merck Index 9139

Related Documents

Citations of This Product

1. Yechun Jiang, Yu Jin, Chengcheng Feng, Yayun Wu, Weinan Zhang, Liang Xiao, Zhaoyou Chu, Benjin Chen, Yan Ma, Haisheng Qian, Lingling Xu.  (2023)  Engineering Hyaluronic Acid Microneedles Loaded with Mn2+ and Temozolomide for Topical Precision Therapy of Melanoma.  Advanced Healthcare Materials,    (2303215).  [PMID:38112062] [10.1002/adhm.202303215]
2. Li Yatian, Gao Zhenyue, Wang Yuhong, Pang Bo, Zhang Binbin, Hu Ruxin, Wang Yuqing, Liu Chao, Zhang Xuebin, Yang Jingxuan, Mei Mei, Wang Yongzhi, Zhou Xuan, Li Min, Ren Yu.  (2023)  Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma.  Nature Communications,  14  (1): (1-19).  [PMID:37429858] [10.1038/s41467-023-39845-z]
3. Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang.  (2023)  Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting.  JOURNAL OF LIPOSOME RESEARCH,      [PMID:36974836] [10.1080/08982104.2023.2191718]
4. Hou Xiaoying, Du Hongzhi, Deng Yufei, Wang Haiping, Liu Jinmi, Qiao Jialu, Liu Wei, Shu Xiji, Sun Binlian, Liu Yuchen.  (2023)  Gut microbiota mediated the individualized efficacy of Temozolomide via immunomodulation in glioma.  Journal of Translational Medicine,  21  (1): (1-15).  [PMID:36927689] [10.1186/s12967-023-04042-5]
5. Xiaoyi Shi, Meng Li, Qiming Huang, Liuming Xie, Zhibing Huang.  (2023)  Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways.  ACS Chemical Neuroscience,  14  (7): (1331–1341).  [PMID:36917811] [10.1021/acschemneuro.3c00104]
6. Su Jie, Yin Wei, Huo Mengmeng, Yao Qing, Ding Liqiong.  (2023)  Induction of apoptosis in glioma cells by lycorine via reactive oxygen species generation and regulation of NF-κB pathways.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,  396  (6): (1247-1255).  [PMID:36715733] [10.1007/s00210-023-02384-x]
7. Zhou Songlei, Huang Yukun, Chen Yu, Liu Yipu, Xie Laozhi, You Yang, Tong Shiqiang, Xu Jianpei, Jiang Gan, Song Qingxiang, Mei Ni, Ma Fenfen, Gao Xiaoling, Chen Hongzhuan, Chen Jun.  (2023)  Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma.  Nature Communications,  14  (1): (1-20).  [PMID:36702831] [10.1038/s41467-023-35957-8]
8. Chen Bo, Li Xiaoli, Wu Lihong, Zhou Duanfang, Song Yi, Zhang Limei, Wu Qiuya, He Qichen, Wang Gang, Liu Xu, Hu Hui, Zhou Weiying.  (2022)  Quercetin Suppresses Human Glioblastoma Migration and Invasion via GSK3β/β-catenin/ZEB1 Signaling Pathway.  Frontiers in Pharmacology,  13  (4678).  [PMID:36386155] [10.3389/fphar.2022.963614]
9. Hu Keqi, Zhou Daquan, Rao Linlin, Wang Peng, Xiang Chunxiang, Chen Feng.  (2021)  A Multifunctional AIE Nanoprobe as a Drug Delivery Bioimaging and Cancer Treatment System.  Frontiers in Bioengineering and Biotechnology,  (1034).  [PMID:34820365] [10.3389/fbioe.2021.766470]
10. Mingming Sun, Hao Sheng, Tingfeng Wu, Jiaqi Song, Huanran Sun, Yingzhi Wang, Jiyan Wang, Zhen Li, Huifang Zhao, Junzhen Tan, Yanping Li, Guo Chen, Qingrong Huang, Yuan Zhang, Bei Lan, Shuangping Liu, Changliang Shan, Shuai Zhang.  (2021)  PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.  BIOCHEMICAL PHARMACOLOGY,  192  (114736).  [PMID:34411567] [10.1016/j.bcp.2021.114736]
11. Man Xu, Guangmeng Li, Haoxiang Zhang, Xiaoming Chen, Yi Li, Qianming Yao, Maobin Xie.  (2020)  Sequential delivery of dual drugs with nanostructured lipid carriers for improving synergistic tumor treatment effect.  DRUG DELIVERY,  27  (1): (983-995).  [PMID:32611218] [10.1080/10717544.2020.1785581]
12. Zeng Xiaofan, Wang Qi, Tan Xuan, Jia Le, Li Yuwei, Hu Mingdi, Zhang Zhijie, Bai Xicheng, Zhu Yanhong, Yang Xiangliang.  (2019)  Mild thermotherapy and hyperbaric oxygen enhance sensitivity of TMZ/PSi nanoparticles via decreasing the stemness in glioma.  JOURNAL OF NANOBIOTECHNOLOGY,  17  (1): (1-12).  [PMID:30935403] [10.1186/s12951-019-0483-1]
13. Yuanyuan Xie, Xiaofan Zeng, Xian Wu, Jun Hu, Yanhong Zhu, Xiangliang Yang.  (2018)  Hyperbaric oxygen as an adjuvant to temozolomide nanoparticle inhibits glioma growth by inducing G2/M phase arrest.  Nanomedicine,      [PMID:29473458] [10.2217/nnm-2017-0395]
14. Bin Du, Changqing Hong, Xinghong Zhang, Jiazhi Wang, Qiang Qu.  (2018)  Preparation and mechanical behaviors of SiOC-modified carbon-bonded carbon fiber composite with in-situ growth of three-dimensional SiC nanowires.  JOURNAL OF THE EUROPEAN CERAMIC SOCIETY,  38  (2272).  [PMID:] [10.1016/j.jeurceramsoc.2018.01.002]
15. Yao‑Dong Chen, Yu Zhang, Tian‑Xiu Dong, Yu‑Tong Xu, Wei Zhang, Ting‑Ting An, Peng‑Fei Liu, Xiu‑Hua Yang.  (2017)  Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.  Molecular Medicine Reports,  16  (6): (9401-9408).  [PMID:29039593] [10.3892/mmr.2017.7769]
16. Qicheng Chen, Li Ye, Jiajun Fan, Xuyao Zhang, Huan Wang, Siyang Liao, Ping Song, Ziyu Wang, Shaofei Wang, Yubin Li, Jingyun Luan, Yichen Wang, Wei Chen, Wenjing Zai, Ping Yang, Zhonglian Cao, Dianwen Ju.  (2017)  Autophagy suppression potentiates the anti-glioblastoma effect of asparaginase in vitro and in vivo.  Oncotarget,  (53): ( 91052–91066).  [PMID:29207624] [10.18632/oncotarget.19409]
17. Nan Wang, Pei Sun, Mingming Lv, Gangsheng Tong, Xin Jin, Xinyuan Zhu.  (2017)  Mustard-inspired delivery shuttle for enhanced blood–brain barrier penetration and effective drug delivery in glioma therapy.  Biomaterials Science,  (5): (1041-1050).  [PMID:28378865] [10.1039/C7BM00133A]

References

1. Yu J et al..  (2022)  SOCS5 contributes to temozolomide resistance in glioblastoma by regulating Bcl-2-mediated autophagy..  Bioengineered,  13  (6): (14125-14137).  [PMID:35730472]
2. Yechun Jiang, Yu Jin, Chengcheng Feng, Yayun Wu, Weinan Zhang, Liang Xiao, Zhaoyou Chu, Benjin Chen, Yan Ma, Haisheng Qian, Lingling Xu.  (2023)  Engineering Hyaluronic Acid Microneedles Loaded with Mn2+ and Temozolomide for Topical Precision Therapy of Melanoma.  Advanced Healthcare Materials,    (2303215).  [PMID:38112062] [10.1002/adhm.202303215]
3. Li Yatian, Gao Zhenyue, Wang Yuhong, Pang Bo, Zhang Binbin, Hu Ruxin, Wang Yuqing, Liu Chao, Zhang Xuebin, Yang Jingxuan, Mei Mei, Wang Yongzhi, Zhou Xuan, Li Min, Ren Yu.  (2023)  Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma.  Nature Communications,  14  (1): (1-19).  [PMID:37429858] [10.1038/s41467-023-39845-z]
4. Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang.  (2023)  Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting.  JOURNAL OF LIPOSOME RESEARCH,      [PMID:36974836] [10.1080/08982104.2023.2191718]
5. Hou Xiaoying, Du Hongzhi, Deng Yufei, Wang Haiping, Liu Jinmi, Qiao Jialu, Liu Wei, Shu Xiji, Sun Binlian, Liu Yuchen.  (2023)  Gut microbiota mediated the individualized efficacy of Temozolomide via immunomodulation in glioma.  Journal of Translational Medicine,  21  (1): (1-15).  [PMID:36927689] [10.1186/s12967-023-04042-5]
6. Xiaoyi Shi, Meng Li, Qiming Huang, Liuming Xie, Zhibing Huang.  (2023)  Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways.  ACS Chemical Neuroscience,  14  (7): (1331–1341).  [PMID:36917811] [10.1021/acschemneuro.3c00104]
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