Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T125922-25mg | 25mg | In stock | $64.90 | |
T125922-100mg | 100mg | In stock | $169.90 | |
T125922-500mg | 500mg | In stock | $765.90 |
Topoisomerase II inhibitor
Synonyms | 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) | Vehem | VM26 | VM-26 | (5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(2-thienyl)-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethox |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Teniposide is a glycoside-derivative of podophyllotoxin, has cytostatic effect. Teniposide inhibits Topo II(topoisomerase II)while induces apoptosis.Topoisomerase II inhibitor. A podophyllotoxin derivative. Induces apoptosis in vitro and in vivo . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | DNA topoisomerase II inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | A derivative of podophyllotoxin that has shown cytostatic effect & inhibition of topoisomerase II. |
ALogP | 1.2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488189868 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488189868 |
IUPAC Name | (5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one |
INCHI | InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1 |
InChi Key | NRUKOCRGYNPUPR-QBPJDGROSA-N |
Canonical SMILES | COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)OC6C(C(C7C(O6)COC(O7)C8=CC=CS8)O)O |
Isomeric SMILES | COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O[C@H]6[C@@H]([C@H]([C@H]7[C@H](O6)CO[C@H](O7)C8=CC=CS8)O)O |
PubChem CID | 452548 |
Molecular Weight | 656.65 |
DrugBank Ligand | DB00444 |
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PubChem CID | 452548 |
CAS Registry No. | 29767-20-2 |
ChEMBL Ligand | CHEMBL452231 |
Wikipedia | Teniposide |
ChEBI | CHEBI:75988 |
RCSB PDB Ligand | 9TP |
DrugCentral Ligand | 2590 |
PubChem SID | 488189868 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K1914014 | Certificate of Analysis | Jun 09, 2023 | T125922 |
D2321225 | Certificate of Analysis | Mar 15, 2023 | T125922 |
D2321230 | Certificate of Analysis | Mar 15, 2023 | T125922 |
D2321236 | Certificate of Analysis | Mar 15, 2023 | T125922 |
D2321238 | Certificate of Analysis | Mar 15, 2023 | T125922 |
D2321241 | Certificate of Analysis | Mar 15, 2023 | T125922 |
E1528013 | Certificate of Analysis | Jan 12, 2023 | T125922 |
Solubility | Soluble in acetone, dimethyl formamide, methanol (slightly), and DMSO (10 mg/ml). Insoluble in water. |
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Sensitivity | Heat sensitive |
Specific Rotation[α] | -111° (C=1,CHCl3:MeOH=9:1) |
Melt Point(°C) | 247 °C(dec.) |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H350:May cause cancer |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
Merck Index | 9145 |
1. Yifan Wu, Xiaoxia Gong, Jianzhong Shen, Kui Zhu. (2023) Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages. Journal of Advanced Research, [PMID:37290606] [10.1016/j.jare.2023.05.010] |
2. Chunsheng Wu, Xiangting Yi, Renzhi Xu, Maokuan Zhang, Yan Xu, Yan Ma, Li Gao, Zhengbao Zha. (2020) Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants. DRUG DELIVERY, 27 (1): (974-982). [PMID:32611260] [10.1080/10717544.2020.1787558] |
1. Yifan Wu, Xiaoxia Gong, Jianzhong Shen, Kui Zhu. (2023) Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages. Journal of Advanced Research, [PMID:37290606] [10.1016/j.jare.2023.05.010] |
2. Chunsheng Wu, Xiangting Yi, Renzhi Xu, Maokuan Zhang, Yan Xu, Yan Ma, Li Gao, Zhengbao Zha. (2020) Biodistribution of etoposide via intratumoral chemotherapy with etoposide-loaded implants. DRUG DELIVERY, 27 (1): (974-982). [PMID:32611260] [10.1080/10717544.2020.1787558] |