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Tenofovir alafenamide fumarate - 10mM in DMSO, high purity , CAS No.379270-38-9
Reverse Transcriptase Inhibitors
Basic Description Synonyms Tenofovir Alafenamide fumarate | GS-7340 fumarate | 379270-38-9 | TAF fumarate | GS-7340 (fumarate) | GS-7340 monofumarate | H2S5S51WW6 | GS-7339 monofumarate | Tenofovir alafenamide monofumarate | L-Alanine, N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)ph Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
Tenofovir alafenamide fumarate Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Targets
reverse transcriptase
Product Properties ALogP 1.565 HBD Count 2 Rotatable Bond 14
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (E)-but-2-enedioic acid;propan-2-yl (2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate INCHI InChI=1S/C21H29N6O5P.C4H4O4/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27;5-3(6)1-2-4(7)8/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24);1-2H,(H,5,6)(H,7,8)/b;2-1+/t15-,16+,33+;/m1./s1 InChi Key MEJAFWXKUKMUIR-FHPNUNMMSA-N Canonical SMILES CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OC3=CC=CC=C3.C(=CC(=O)O)C(=O)O Isomeric SMILES C[C@H](CN1C=NC2=C(N=CN=C21)N)OC[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC3=CC=CC=C3.C(=C/C(=O)O)\C(=O)O PubChem CID 68516365 Molecular Weight 592.54
Chemical and Physical Properties DMSO(mg / mL) Max Solubility 100 DMSO(mM) Max Solubility 168.764977891788 Water(mg / mL) Max Solubility 10 Water(mM) Max Solubility 16.8764977891788
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Warning Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
Precautionary Statements P501: Dispose of contents/container to ...
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P319: Get medical help if you feel unwell.
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