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Home Microbiology Tenofovir disoproxil fumarate - 98%, high purity , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.202138-50-9, Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Tenofovir disoproxil fumarate - 98%, high purity , Human immunodeficiency virus type 1 reverse transcriptase inhibitor, CAS No.202138-50-9, Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Basic Description Synonyms DTXCID804289 | Tenofovir Disoproxil Fumarate | TENOFOVIR DISOPROXIL FUMARATE [EMA EPAR] | Cibacete Violet 2R | SMR003500786 | EVIPLERA COMPONENT TENOFOVIR DISOPROXIL FUMARATE | Tox21_112532 | 9-((R)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)meth Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Tenofovir disoproxil fumarate (tenofovir DF) is a nucleotide analogue with activity against retroviruses, such as human immunodeficiency virus (HIV)-1, HIV-2 and hepadnaviruses.
Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analog Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Action Type INHIBITOR Mechanism of action Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(propan-2-yloxycarbonyloxymethoxy)phosphoryl]oxymethyl propan-2-yl carbonate;(E)-but-2-enedioic acid INCHI InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1 InChi Key VCMJCVGFSROFHV-WZGZYPNHSA-N Canonical SMILES CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C.C(=CC(=O)O)C(=O)O Isomeric SMILES C[C@H](CN1C=NC2=C(N=CN=C21)N)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C.C(=C/C(=O)O)\C(=O)O PubChem CID 6398764 Molecular Weight 635.51
Chemical and Physical Properties Solubility H2O: 3 mg/mL, clear (warmed) Melt Point(°C) 113-115°C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS05 , GHS07 Signal Danger Hazard Statements H319: Causes serious eye irritation
H373: Causes damage to organs through prolonged or repeated exposure
H302: Harmful if swallowed
H318: Causes serious eye damage
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P305+P354+P338: IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P317: Get emergency medical help.
P337+P317: If eye irritation persists: Get medical help.
P319: Get medical help if you feel unwell.
Citations of This Product 1. Qiuhua Zhang, Lingyi Huang, Youjia Wu, Liying Huang, Xiaowen Xu, Renyi Lin. (2022) Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography–Tandem Mass Spectrometry. MOLECULES, 27 (13): (4130). [PMID:35807378 ] [10.3390/molecules27134130 ]
References 1. Qiuhua Zhang, Lingyi Huang, Youjia Wu, Liying Huang, Xiaowen Xu, Renyi Lin. (2022) Study on Quality Control of Compound Anoectochilus roxburghii (Wall.) Lindl. by Liquid Chromatography–Tandem Mass Spectrometry. MOLECULES, 27 (13): (4130). [PMID:35807378 ] [10.3390/molecules27134130 ]
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