Tephrosin - ≥95% (LC/MS-ELSD), high purity , CAS No.76-80-2

  • ≥95%(LC/MS-ELSD)
Item Number
T463880
Grouped product items
SKUSizeAvailabilityPrice Qty
T463880-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$375.90

Basic Description

SynonymsSCHEMBL766277 | (7aR,13aR)-13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one | CS-0016457 | CHEBI:9442 | Deguelinol I;Hydroxydeguelin | (7aR,13aR)-7a-Hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydr
Specifications & Purity≥95%(LC/MS-ELSD)
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Description

Natural product derived from plant source.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-8 (3484 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-1080 (3966 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Raji (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RPMI-7951 (420 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TE-671 (161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-937 (7138 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2780 (11979 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Cholinesterases; ACHE & BCHE (1222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
697 (196 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Helicobacter pylori (3113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacteroides fragilis (1445 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Micrococcus luteus (7463 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16 (5829 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MC-38 (857 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lewis lung carcinoma cell line (1243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (1R,14R)-14-hydroxy-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-3(12),4(9),5,10,15,17,19-heptaen-13-one
INCHI InChI=1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1
InChi Key AQBZCCQCDWNNJQ-AUSIDOKSSA-N
Canonical SMILES CC1(C=CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4(C3=O)O)OC)OC)C
Isomeric SMILES CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@]4(C3=O)O)OC)OC)C
PubChem CID 114909
UN Number 3077
Molecular Weight 410.42

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Flash Point(°F)Not applicable
Flash Point(°C)Not applicable

Safety and Hazards(GHS)

Pictogram(s) GHS09
Signal Warning
Hazard Statements

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P391:Collect spillage.

Class 9
RIDADR UN 3077 9 / PGIII

Related Documents

References

1. Abiy Yenesew,Solomon Derese,Jacob O Midiwo,Matthias Heydenreich,Martin G Peter.  (2003-10-17)  Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti..  Pest management science,  59  ((10)): (1159-1161).  [PMID:14561074]
2. Shugeng Cao,Jennifer K Schilling,James S Miller,Rabodo Andriantsiferana,Vincent E Rasamison,David G I Kingston.  (2004-03-27)  Cytotoxic compounds from Mundulea chapelieri from the Madagascar Rainforest..  Journal of natural products,  67  ((3)): (454-456).  [PMID:15043430]
3. Abiy Yenesew,John T Kiplagat,Solomon Derese,Jacob O Midiwo,Jacques M Kabaru,Matthias Heydenreich,Martin G Peter.  (2006-02-18)  Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata..  Phytochemistry,  67  ((10)): (988-991).  [PMID:16483619]
4. Hisashi Matsuda,Kazutoshi Yoshida,Katsutoshi Miyagawa,Yasunobu Asao,Saya Takayama,Souichi Nakashima,Fengming Xu,Masayuki Yoshikawa.  (2006-12-13)  Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa..  Bioorganic & medicinal chemistry,  15  ((3)): (1539-1546).  [PMID:17158054]
5. Haoyu Ye,Lijuan Chen,Yanfang Li,Aihua Peng,Afu Fu,Hang Song,Minghai Tang,Houding Luo,Youfu Luo,Yongbin Xu,Jianyou Shi,Yuquan Wei.  (2007-12-18)  Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography..  Journal of chromatography. A,  1178  ((1-2)): (101-107).  [PMID:18082754]
6. José Garcia,Sofia Barluenga,Kristin Beebe,Len Neckers,Nicolas Winssinger.  (2010-06-24)  Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action..  Chemistry (Weinheim an der Bergstrasse, Germany),  16  ((32)): (9767-9771).  [PMID:20572190]
7. Song Gao,Ya-ming Xu,Frederick A Valeriote,A A Leslie Gunatilaka.  (2011-04-02)  Pierreiones A-D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from Antheroporum pierrei..  Journal of natural products,  74  ((4)): (852-856).  [PMID:21452840]
8. Yunjin Choi,Jeong-Hyung Lee.  (2011-11-30)  The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells..  Cancer biology & therapy,  12  ((11)): (989-996).  [PMID:22123175]
9. Lu-Rong Xu,Shan Li,Jun Wu,Si Zhang.  (2007-10-09)  [Rotenoids from Derris trifoliata]..  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,  30  ((6)): (660-662).  [PMID:17918433]
10. Tsung-Hsien Chou,Ih-Sheng Chen,Tsong-Long Hwang,Tai-Chi Wang,Tzong-Huei Lee,Lin-Yang Cheng,Ya-Chih Chang,Jui-Ying Cho,Jih-Jung Chen.  (2008-09-27)  Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils..  Journal of natural products,  71  ((10)): (1692-1695).  [PMID:18817445]
11. Nguyen Tien Dat,Jeong-Hyung Lee,Kyeong Lee,Young-Soo Hong,Young Ho Kim,Jung Joon Lee.  (2008-10-10)  Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression..  Journal of natural products,  71  ((10)): (1696-1700).  [PMID:18841906]
12. Sujin Choi,Yunjin Choi,Nguyen Tien Dat,Cheol Hwangbo,Jung Joon Lee,Jeong-Hyung Lee.  (2010-01-09)  Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells..  Cancer letters,  293  ((1)): (23-30).  [PMID:20056314]
13. Jing Li,Xiao-Lu Wang,Yu-Chun Fang,Chang-Yun Wang.  (2010-11-10)  Tephrosin-induced autophagic cell death in A549 non-small cell lung cancer cells..  Journal of Asian natural products research,  12  ((11)): (992-1000).  [PMID:21061222]
14. Xueling Qu,Yunpeng Diao,Zhen Zhang,Shouyu Wang,Yujie Jia.  (2013-10-23)  Evaluation of anti-bacterial and wound healing activity of the fruits of Amorpha fruticosa L..  African journal of traditional, complementary, and alternative medicines : AJTCAM,  10  ((3)): (458-468).  [PMID:24146475]

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