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T137617-1g

In stock

$69.90

T137617-5g

In stock

$297.90

Basic Description

Synonyms	terfenadine\|50679-08-8\|Seldane\|Ternadin\|Triludan\|Teldane\|Allerplus\|Teldanex\|Aldaban\|Terdin\|Terfenadina\|RMI 9918\|RMI-9918\|1-(4-(tert-butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol\|alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylm
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST, CHANNEL BLOCKER, INHIBITOR
Mechanism of action	Inhibitor of CYP2J2;Antagonist of H 1 receptor;Channel blocker of K v10.1;Channel blocker of K v11.1
Product Description	Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats

Product Properties

ALogP	6.6

Associated Targets

CTH Tchem Cystathionine gamma-lyase 0 Activities

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CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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CETP Tchem Cholesteryl ester transfer protein 0 Activities

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DRD2 Tclin D(2) dopamine receptor 0 Activities

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DRD4 Tchem D(4) dopamine receptor 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 1 Activities

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ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

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GABRA1 Tclin Gamma-aminobutyric acid receptor subunit alpha-1 0 Activities

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ELANE Tclin Neutrophil elastase 0 Activities

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EGFR Tclin Epidermal growth factor receptor 0 Activities

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HMGCR Tclin 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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HRH1 Tclin Histamine H1 receptor 6 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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SLC6A4 Tclin Sodium-dependent serotonin transporter 0 Activities

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SIGMAR1 Tclin Sigma non-opioid intracellular receptor 1 0 Activities

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PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0 Activities

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PTGS1 Tclin Prostaglandin G/H synthase 1 0 Activities

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CA2 Tclin Carbonic anhydrase 2 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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CHRM3 Tclin Muscarinic acetylcholine receptor M3 0 Activities

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ADRA2B Tclin Alpha-2B adrenergic receptor 0 Activities

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ADRA2C Tclin Alpha-2C adrenergic receptor 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 1 Activities

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ADORA2A Tclin Adenosine receptor A2a 0 Activities

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ACHE Tclin Acetylcholinesterase 0 Activities

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HTR7 Tclin 5-hydroxytryptamine receptor 7 0 Activities

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ADRA1A Tclin Alpha-1A adrenergic receptor 0 Activities

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AR Tclin Androgen receptor 0 Activities

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AKR1B1 Tclin Aldose reductase 0 Activities

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ADORA1 Tclin Adenosine receptor A1 0 Activities

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HTR1A Tclin 5-hydroxytryptamine receptor 1A 0 Activities

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ADORA3 Tchem Adenosine receptor A3 0 Activities

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HTR3A Tclin 5-hydroxytryptamine receptor 3A 0 Activities

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HTR6 Tchem 5-hydroxytryptamine receptor 6 0 Activities

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HTR2B Tclin 5-hydroxytryptamine receptor 2B 2 Activities

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F2 Tclin Prothrombin 0 Activities

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EDNRA Tclin Endothelin-1 receptor 0 Activities

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EDNRB Tclin Endothelin receptor type B 0 Activities

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KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 27 Activities

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OPRD1 Tclin Delta-type opioid receptor 0 Activities

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OPRK1 Tclin Kappa-type opioid receptor 0 Activities

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OPRM1 Tclin Mu-type opioid receptor 0 Activities

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NOS2 Tchem Nitric oxide synthase, inducible 0 Activities

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TACR1 Tclin Substance-P receptor 0 Activities

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NOS1 Tchem Nitric oxide synthase, brain 0 Activities

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MTOR Tclin Serine/threonine-protein kinase mTOR 0 Activities

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Names and Identifiers

IUPAC Name	1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol
INCHI	InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3
InChi Key	GUGOEEXESWIERI-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O
Isomeric SMILES	CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O
WGK Germany	2
PubChem CID	5405
Molecular Weight	471.67

Database links

PubChem CID	5405
ChEBI	CHEBI:9453
CAS Registry No.	50679-08-8
ChEMBL Ligand	CHEMBL17157
DrugBank Ligand	DB00342
BindingDB Ligand	50017376
Wikipedia	Terfenadine
DrugCentral Ligand	2600
GPCRdb Ligand	terfenadine

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
C2405713	Certificate of Analysis	Jan 30, 2024	T137617
A2310191	Certificate of Analysis	Dec 30, 2022	T137617
A2310377	Certificate of Analysis	Dec 30, 2022	T137617

Chemical and Physical Properties

Solubility	Soluble in chloroform, DMSO (100 nM), ethanol (25 nM), and water (0.001 g/100 ml) at 30°C
Sensitivity	air & heat sensitive
Melt Point(°C)	145-152℃

Safety and Hazards(GHS)

Hazard Statements	H413:May cause long lasting harmful effects to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ...
WGK Germany	2

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Terfenadine - 98%, high purity , CAS No.50679-08-8, Inhibitor of CYP2J2;Antagonist of H 1 receptor;Channel blocker of K v10.1;Channel blocker of K v11.1