The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
tesevatinib , Receptor protein-tyrosine kinase erbB-2 inhibitor, CAS No.781613-23-8, Receptor protein-tyrosine kinase erbB-2 inhibitor
Basic Description Synonyms Tesevatinib|XL647|XL-647|781613-23-8|EXEL-7647|KD019|KD-019|XL 647|EXEL 7647|KD 019|KD-020|F6XM2TN5A1|N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine|N-(3,4-Dichloro-2-fluorop Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Receptor protein-tyrosine kinase erbB-2 inhibitor Product Description Tesevatinib (XL-647; EXEL-7647; KD-019) is a multi-target tyrosine kinase inhibitor; inhibits EGFR, ErbB2, KDR, Flt4 and EphB4 kinase with IC50s of 0.3, 16, 1.5, 8.7, and 1.4 nM.
Names and Identifiers IUPAC Name 7-[[(3aS,6aR)-2-methyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]methoxy]-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine INCHI InChI=1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13?,14-,15+ InChi Key HVXKQKFEHMGHSL-GOOCMWNKSA-N Canonical SMILES CN1CC2CC(CC2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC Isomeric SMILES CN1C[C@H]2CC(C[C@H]2C1)COC3=C(C=C4C(=C3)N=CN=C4NC5=C(C(=C(C=C5)Cl)Cl)F)OC Alternate CAS 781613-23-8 PubChem CID 10458325 MeSH Entry Terms EXEL-7647;N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,6aS)-2-methyloctahydrocyclopenta(c)pyrrol-5-yl)methoxy)-4-quinazolinamine;tesevatinib;XL-647;XL647 Molecular Weight 491.39
Chemical and Physical Properties Solubility DMSO: 45 mg/mL (91.58 mM)
References 1. Gendreau SB, Ventura R, Keast P, Laird AD, Yakes FM, Zhang W, Bentzien F, Cancilla B, Lutman J, Chu F et al. . (2007) Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647.. Clin Cancer Res, 13 (12): (3713-23). [PMID:17575237 ]
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
