Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T135203-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $178.90 | |
T135203-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $183.90 | |
T135203-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $563.90 | |
T135203-5g | 5g | In stock | $2,535.90 |
Potent, reversible VMAT2 inhibitor
Synonyms | FT-0771873 | CHEBI:9467 | tetra Benazin | 2H-Benzo(a)quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)- | NCGC00160421-02 | Rubigen | 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-Benzo[a]quinolizin-2-one | 2H-Benz |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Tetrabenazine is a reversible type 2 vesicular monoamine transporter (VMAT) inhibitor. It depletes dopamine stores.Potent, reversible VMAT2 inhibitor (IC 50 = 3.2 nM, K i = 100 nM). Depletes monoamines stores and decreases uptake into synaptic vesicles. S |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of Vesicular monoamine transporter 1;Inhibitor of Vesicular monoamine transporter 2 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Usually used for dopamine uptake assays in mouse brain cells,and also has been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells. |
ALogP | 2.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | ||
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | DailyMed: [1] | |
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | ||
Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | ALA203 | Epidermal growth factor receptor erbB1 | SINGLE PROTEIN | Homo sapiens | PubMed: [1] |
IUPAC Name | 9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one |
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INCHI | InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3 |
InChi Key | MKJIEFSOBYUXJB-UHFFFAOYSA-N |
Canonical SMILES | CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC |
Isomeric SMILES | CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC |
WGK Germany | 3 |
RTECS | DK2275000 |
PubChem CID | 6018 |
Molecular Weight | 317.42 |
Beilstein | 40090 |
Sensitivity | Air Sensitive,Heat Sensitive |
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Melt Point(°C) | 127 °C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | DK2275000 |
Merck Index | 9182 |
1. Jankovic J. (2016) Dopamine depleters in the treatment of hyperkinetic movement disorders.. Expert Opin Pharmacother, 17 (18): (2461-2470). [PMID:27819145] [10.1021/op500134e] |