Tetrahydroberberine - 10mM in DMSO, high purity , CAS No.522-97-4

Item Number

T424486

• Synonyms: Canadine | Tetrahydroberberine | 522-97-4 | Xanthopuccine | Canadin | dl-Canadine | 29074-38-2 | Berberine, tetrahydro- | dl-Tetrahydroberberine | NSC 94918 | (d,l)-Tetrahydroberberine | 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine,5,8,13,13a-tetrahydro-9,10-dimethoxy- | CHEMB
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity fordopamine D2(antagonist, pKi = 6.08) and5-HT1A(agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.

Targets

D2 receptor ; 5-HT1A 6.08(pKi); 5.38(pKi)

In vivo

Oral administration of THB not only resulted in significantly accelerated gastric emptying of normal rats in a bell-shaped relationship, with a maximal efficacy at a dose of 30 μg/kg, but also restored the delayed gastric emptying caused by apomorphine, which might be mediated by an antidopaminergic effect.