TG101209 is a potent and small molecule JAK2-selective kinase inhibitor with IC50 of 6, 25, 17 and 169 nM for JAK2, FLT3, RET and JAK3, respectively.TG101209 is useful for myeloproliferative disorder
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations; TG101209 inhibit BRD4 activity with IC50 of 130 nM. An inhibitor of JAK2, Flt-3, Ret, and JAK3
Associated Targets(Human)
BRD4TchemBromodomain-containing protein 4 (5 Activities)
D2318625