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TG101209 - 98%, high purity , CAS No.936091-14-4
Discover TG101209 by Aladdin Scientific in 98% for only $75.90. Available - in Ligands at Aladdin Scientific. Tags: .
Basic Description Synonyms TG101209|936091-14-4|TG-101209|TG 101209|N-tert-butyl-3-(5-methyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide|N-tert-butyl-3-[[5-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide|N-(ter Specifications & Purity 98% Storage Temp Store at -20°C Shipped In Dry ice Product Description TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations; TG101209 inhibit BRD4 activity with IC50 of 130 nM.
Names and Identifiers Pubchem Sid 488199413 IUPAC Name N-tert-butyl-3-[[5-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide INCHI InChI=1S/C26H35N7O2S/c1-19-18-27-25(29-20-9-11-22(12-10-20)33-15-13-32(5)14-16-33)30-24(19)28-21-7-6-8-23(17-21)36(34,35)31-26(2,3)4/h6-12,17-18,31H,13-16H2,1-5H3,(H2,27,28,29,30) InChi Key JVDOKQYTTYUYDV-UHFFFAOYSA-N Canonical SMILES CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)N4CCN(CC4)C Isomeric SMILES CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)N4CCN(CC4)C PubChem CID 16722832 Molecular Weight 509.67
Chemical and Physical Properties Solubility Ethanol:<1 mg/mL；DMSO:94 mg/mL (184.4 mM)；H2O:<1 mg/mL
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