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G protein-coupled receptors (GPCRs)
Prostanoid receptors
TG11-77 , CAS No.T614405, Antagonist of DP 1 receptor;Antagonist of EP 2 receptor;Antagonist of EP 4 receptor

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TG11-77 , CAS No.T614405, Antagonist of DP 1 receptor;Antagonist of EP 2 receptor;Antagonist of EP 4 receptor

Moligand™

PubChem CID: 145996528

Item Number

T614405

Grouped product items
SKU	Size	Availability	Price	Qty
T614405-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
T614405-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,420.90

View related series

DP1 receptor Antagonist EP2 receptor Antagonist EP4 receptor Antagonist

Basic Description

Synonyms	compound 20o
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of DP 1 receptor;Antagonist of EP 2 receptor;Antagonist of EP 4 receptor

Associated Targets

PTGER2 Tclin Prostaglandin E2 receptor EP2 subtype 0 Activities

Discover Target: PTGER2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGDR Tclin Prostaglandin D2 receptor 0 Activities

Discover Target: PTGDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGER4 Tclin Prostaglandin E2 receptor EP4 subtype 0 Activities

Discover Target: PTGER4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGIR Tclin Prostacyclin receptor 0 Activities

Discover Target: PTGIR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TFDP1 Tbio Transcription factor Dp-1 0 Activities

Discover Target: TFDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-((4,6-Dimethylpyridin-2-yl)amino)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide
INCHI	InChI=1S/C23H24N6O/c1-14-10-15(2)27-21(11-14)29-23-25-12-17(13-26-23)22(30)24-9-8-18-16(3)28-20-7-5-4-6-19(18)20/h4-7,10-13,28H,8-9H2,1-3H3,(H,24,30)(H,25,26,27,29)
InChi Key	NZOAMVGASFFEJH-UHFFFAOYSA-N
Canonical SMILES	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C
Isomeric SMILES	CC1=CC(=NC(=C1)NC2=NC=C(C=N2)C(=O)NCCC3=C(NC4=CC=CC=C43)C)C
PubChem CID	145996528

Database links

GPCRdb Ligand	TG11-77
PubChem CID	145996528

Certificates

Certificate of Analysis(COA)

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References

1. Amaradhi R, Banik A, Mohammed S, Patro V, Rojas A, Wang W, Motati DR, Dingledine R, Ganesh T. (2020) Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models.. J Med Chem, 63 (3): (1032-1050). [PMID:31904232]

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