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TH 588 - 10mM in DMSO, high purity , CAS No.1609960-31-7
Basic Description Synonyms TH588 | 1609960-31-7 | N4-Cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine | N~4~-Cyclopropyl-6-(2,3-Dichlorophenyl)pyrimidine-2,4-Diamine | TH 588 | TH-588 | CHEMBL3782004 | 4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine | 6-(2,3-Dichlorophenyl)-N4 Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Potent MTH1 inhibitor (IC50= 5 nM). Induces oxidative DNA damage and reduces survival in cancer cells. Inhibits growth of breast and colorectal cancer xenografts in mice. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 4-N-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine INCHI InChI=1S/C13H12Cl2N4/c14-9-3-1-2-8(12(9)15)10-6-11(17-7-4-5-7)19-13(16)18-10/h1-3,6-7H,4-5H2,(H3,16,17,18,19) InChi Key PNMYJIOQIAEYQL-UHFFFAOYSA-N Canonical SMILES C1CC1NC2=NC(=NC(=C2)C3=C(C(=CC=C3)Cl)Cl)N Isomeric SMILES C1CC1NC2=NC(=NC(=C2)C3=C(C(=CC=C3)Cl)Cl)N PubChem CID 73389731 Molecular Weight 295.17
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