Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T424336-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 |
Immunomodulator and anticancer agent
Synonyms | thalidomide | 50-35-1 | Thalomid | 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | Contergan | Distaval | Pantosediv | Softenon | (+/-)-THALIDOMIDE | Kevadon | Sedoval | Theophilcholine | Algosediv | Corronarobetin | Ectiluran | Enterosediv | Gastrinide | Nerosedyn | Neurosedin | Neurosedy |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Thalidomide was commonly used therapeutically in the late 1950’s, however, it was withdrawn from the market when it was discovered to cause birth defects. More recent research has found Thalidomide to affect key biochemical pathways yielding antiangiogeni |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | A selective inhibitor of TNF alpha biosynthesis shown to have immunomodulatory and antiangeogenic activity. |
ALogP | 0.3 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
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INCHI | InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) |
InChi Key | UEJJHQNACJXSKW-UHFFFAOYSA-N |
Canonical SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O |
Isomeric SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O |
WGK Germany | 3 |
RTECS | TI4375000 |
PubChem CID | 5426 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 258.23 |
Enter Lot Number to search for COA:
Melt Point(°C) | 276 °C |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H302:Harmful if swallowed H360:May damage fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |
RTECS | TI4375000 |
Class | 6.1 |
Merck Index | 9255 |
1. Jingjing Chen, Peipei Li, Yixiu Han, Yuchen Li, Yingxiang Du. (2023) Highly photoluminescent nitrogen-doped carbon quantum dots as a green fluorescence probe for determination of myricetin. FOOD CHEMISTRY, 417 (135920). [PMID:36933427] [10.1016/j.foodchem.2023.135920] |
2. Zhe Zhou, Jing Long, Yuan Wang, YaYun Li, Xu Zhang, Ling Tang, Qi Chang, Zhuo Chen, GaoYun Hu, Shuo Hu, QianBin Li, Cong Peng, Xiang Chen. (2020) Targeted degradation of CD147 proteins in melanoma. BIOORGANIC CHEMISTRY, 105 (104453). [PMID:33197849] [10.1016/j.bioorg.2020.104453] |
1. Jingjing Chen, Peipei Li, Yixiu Han, Yuchen Li, Yingxiang Du. (2023) Highly photoluminescent nitrogen-doped carbon quantum dots as a green fluorescence probe for determination of myricetin. FOOD CHEMISTRY, 417 (135920). [PMID:36933427] [10.1016/j.foodchem.2023.135920] |
2. Zhe Zhou, Jing Long, Yuan Wang, YaYun Li, Xu Zhang, Ling Tang, Qi Chang, Zhuo Chen, GaoYun Hu, Shuo Hu, QianBin Li, Cong Peng, Xiang Chen. (2020) Targeted degradation of CD147 proteins in melanoma. BIOORGANIC CHEMISTRY, 105 (104453). [PMID:33197849] [10.1016/j.bioorg.2020.104453] |