Thapsigargin - ≥95%, high purity , CAS No.67526-95-8

2 Citations
Item Number
T135258
Grouped product items
SKUSizeAvailabilityPrice Qty
T135258-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$98.90
T135258-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$276.90
T135258-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$444.90

Ca 2+ -ATPase inhibitor

Basic Description

Synonyms(-)-Thapsigargin | NCGC00162381-06 | Octanoic Acid [3s-[3alpha, 3abeta, 4alpha,6beta, 6abeta, 7beta, 8alpha(Z), 9balpha]]-6-(Acetyloxy)-2,3,-3a,4,5,6,6a,7,8,9b-Decahydro-3,3a-Dihydroxy-3,6,9-Trimethyl-8-[(2-Methyl-1-Oxo-2-Butenyl)oxy]-2-Oxo-4-(1-Oxobutoxy
Specifications & PurityMoligand™, ≥95%
Biochemical and Physiological MechanismsPotent, cell-permeable, IP3-independent intracellular calcium releaser. Blocks the transient increase in intracellular Ca2+ induced by angiostatin and endostatin. Induces apoptosis by disrupting intracellular free Ca2+ levels; incorporated into chemothera
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50=30 nM). It may be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of protein kinase C activation.
An inducer of stored Ca2+ release.

Associated Targets(Human)

ATP2A1 Tchem Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATP2A1 Tchem Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (55 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
5637 (630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A 172 (535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A204 (242 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2058 (690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-375 (9258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-427 (643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A673 (619 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGS (1999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BT-20 (503 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BT-474 (2113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BXPC-3 (2997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C8166 (1658 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA46 (271 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-1 (44928 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-1 (518 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-3 (339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-6 (398 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAPAN-1 (772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COR-L23 (253 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Daoy (570 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Daudi (625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DMS-79 (150 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DMS-273 (14108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EVSA-T (142 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
G-361 (890 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
G-401 (156 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-1080 (3966 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HuCCT-1 (128 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Huh-7 (12904 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HuTu80 (255 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
IM-9 (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J82 (505 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JAR (316 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
JIYOYE (162 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
polC DNA polymerase III (243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania donovani (89745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bos taurus (956 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei rhodesiense (7991 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF S-180 (1031 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COS-7 (515 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EL4 (235 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDCK (10148 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H4 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mast cell (119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATP2A1 Sarcoplasmic/endoplasmic reticulum calcium ATP-ase (121 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ryanodien receptor (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
INCHI InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChi Key IXFPJGBNCFXKPI-FSIHEZPISA-N
Canonical SMILES CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
Isomeric SMILES CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
WGK Germany 3
PubChem CID 446378
Molecular Weight 650.75

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
K2113552Certificate of AnalysisAug 18, 2023 T135258
K2113553Certificate of AnalysisAug 18, 2023 T135258
H2330579Certificate of AnalysisAug 17, 2023 T135258
H2330580Certificate of AnalysisAug 17, 2023 T135258
I2021077Certificate of AnalysisAug 05, 2022 T135258
I2021076Certificate of AnalysisAug 05, 2022 T135258
A2309412Certificate of AnalysisSep 29, 2021 T135258
K2113551Certificate of AnalysisSep 29, 2021 T135258

Chemical and Physical Properties

SolubilitySoluble in DMSO (20 mg/ml), ethanol (20 mg/ml), and acetone
SensitivityLight sensitive;Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P342+P311:IF experiencing respiratory symptoms: Call a POISON CENTER/doctor/...

WGK Germany 3

Related Documents

FAQs and Articles

Citations of This Product

1. Gao Xiu Kui, Sheng Zu Kang, Lu Ye Hong, Sun Yu Ting, Rao Xi Sheng, Shi Lin Jing, Cong Xiao Xia, Chen Xiao, Wu Hao Bo, Huang Man, Zheng Qiang, Guo Jian-sheng, Jiang Liang Jun, Zheng Li Ling, Zhou Yi Ting.  (2023)  VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling.  Cell Discovery,  (1): (1-18).  [PMID:37528084]
2. Weibo Zhang, Shucheng Zhang, Chong Chen, Ning Liu, Dong Yang, Pengjie Wang, Fazheng Ren.  (2022)  The internalization mechanisms and trafficking of the pea albumin in Caco-2 cells.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  217  (111).  [PMID:35764167]

References

1. Gupta K et al..  (2020)  Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel..  Biomaterials,  259  (120283).  [PMID:32827796]
2. Ye Z et al..  (2021)  Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation..  Nat Commun,  12  (907).  [PMID:33568645]
3. Zhu M et al..  (2017)  Calcium-binding protein S100A14 induces differentiation and suppresses metastasis in gastric cancer..  Cell Death Dis,  (7): (e2938).  [PMID:28726786]
4. Zhu E et al..  (2019)  Classical Swine Fever Virus Infection Induces Endoplasmic Reticulum Stress-Mediated Autophagy to Sustain Viral Replication in vivo and in vitro..  Front Microbiol,  10  (2545).  [PMID:31798542]
5. Fukushima T et al..  (2019)  Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium..  Cell Rep,  29  (12): (4144-4158.e7).  [PMID:31851939]
6. Heise N et al..  (2011)  Effect of dexamethasone on Na+/Ca2+ exchanger in dendritic cells..  Am J Physiol Cell Physiol,  300  (6): (C1306-13).  [PMID:21307349]
7. Klann K et al..  (2020)  Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2a..  Mol Cell,  77  (4): (913-925.e4).  [PMID:31812349]
8. Habib P et al..  (2019)  EPO and TMBIM3/GRINA Promote the Activation of the Adaptive Arm and Counteract the Terminal Arm of the Unfolded Protein Response after Murine Transient Cerebral Ischemia..  Int J Mol Sci,  20  (21):   [PMID:31683519]
9. Vella SA et al..  (2020)  Genetic Indicators for Calcium Signaling Studies in Toxoplasma gondii..  Methods Mol Biol,  2071  (187-207).  [PMID:31758454]
10. Nava MM et al..  (2020)  Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage..  Cell,  181  (4): (800-817.e22).  [PMID:32302590]
11. Wang S et al..  (2020)  Induction of the Unfolded Protein Response during Bovine Alphaherpesvirus 1 Infection..  Viruses,  12  (9):   [PMID:32887282]
12. Casas-Rua V et al..  (2013)  Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of store-operated calcium entry..  Biochem Pharmacol,  86  (11): (1555-63).  [PMID:24095720]
13. Bae E et al..  (2022)  Integrin a3ß1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis..  Nat Commun,  13  (4268).  [PMID:35879332]
14. Abdoul-Azize S et al..  (2017)  Improvement of dexamethasone sensitivity by chelation of intracellular Ca2+ in pediatric acute lymphoblastic leukemia cells through the prosurvival kinase ERK1/2 deactivation..  Oncotarget,  (16): (27339-27352).  [PMID:28423696]
15. Masson SWC et al..  (2017)  Mitochondrial glycerol 3-phosphate facilitates bumblebee pre-flight thermogenesis..  Sci Rep,  (13107).  [PMID:29026172]
16. Waldeck-Weiermair M et al..  (2013)  Molecularly distinct routes of mitochondrial Ca2+ uptake are activated depending on the activity of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA)..  J Biol Chem,  288  (21): (15367-79).  [PMID:23592775]
17. Yang H et al..  (2019)  MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint..  Autophagy,    (1-18).  [PMID:31007149]
18. Liang W et al..  (2021)  Necroptosis activates UPR sensors without disrupting their binding with GRP78..  Proc Natl Acad Sci U S A,  118  (39):   [PMID:34544877]
19. Fan C et al..  (2020)  Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage..  Stem Cell Res Ther,  11  (442).  [PMID:33059742]
20. Saxena S et al..  (2013)  Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival..  Neuron,  80  (80-96).  [PMID:24094105]
21. Pozo-Guisado E et al..  (2013)  Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1..  J Cell Sci,  126  (Pt 14): (3170-80).  [PMID:23687376]
22. Parafati M et al..  (2020)  Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPa/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation..  Int J Mol Sci,  21  (24):   [PMID:33334026]
23. Zhou Y et al..  (2016)  Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its Enhanced Replication in PK-15 Cells..  Viruses,  (2):   [PMID:26907328]
24. Gu Y et al..  (2016)  Porcine Circovirus Type 2 Activates CaMMKß to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium..  Viruses,  (5):   [PMID:27213427]
25. Zhang M et al..  (2018)  Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR..  J Bone Miner Res,      [PMID:30496623]
26. Mahameed M et al..  (2020)  Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy..  Nat Commun,  11  (1304).  [PMID:32161259]
27. Zhang P et al..  (2022)  Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma..  Signal Transduct Target Ther,  (46).  [PMID:35169126]
28. Wendimu MY et al..  (2021)  RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia..  Cell Signal,  83  (109974).  [PMID:33705894]
29. Qiu K et al..  (2022)  Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion..  J Anim Sci Biotechnol,  13  (9).  [PMID:35144690]
30. Jonas KC et al..  (2018)  Temporal reprogramming of calcium signalling via crosstalk of gonadotrophin receptors that associate as functionally asymmetric heteromers..  Sci Rep,  (2239).  [PMID:29396488]
31. Duan J et al..  (2019)  The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses..  Nat Commun,  10  (2299).  [PMID:31127110]
32. Obiedat A et al..  (2020)  The integrated stress response promotes B7H6 expression..  J Mol Med (Berl),  98  (135-148).  [PMID:31838577]
33. Thangthaeng N et al..  (2018)  Walnut extract modulates activation of microglia through alteration in intracellular calcium concentration..  Nutr Res,  49  (88-95).  [PMID:29420996]
34. Gao Xiu Kui, Sheng Zu Kang, Lu Ye Hong, Sun Yu Ting, Rao Xi Sheng, Shi Lin Jing, Cong Xiao Xia, Chen Xiao, Wu Hao Bo, Huang Man, Zheng Qiang, Guo Jian-sheng, Jiang Liang Jun, Zheng Li Ling, Zhou Yi Ting.  (2023)  VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling.  Cell Discovery,  (1): (1-18).  [PMID:37528084]
35. Weibo Zhang, Shucheng Zhang, Chong Chen, Ning Liu, Dong Yang, Pengjie Wang, Fazheng Ren.  (2022)  The internalization mechanisms and trafficking of the pea albumin in Caco-2 cells.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  217  (111).  [PMID:35764167]

Solution Calculators