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Thiocolchicine , CAS No.2730-71-4

≥98%

CAS#: 2730-71-4
Formula: C₂₂H₂₅NO₅S
Molecular Weight: 415.50
EC Number: 220-346-8
PubChem CID: 17648

Item Number

T340761

Grouped product items
SKU	Size	Availability	Price
T340761-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$19.90
T340761-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$98.90
T340761-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$86.90
T340761-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$182.90
T340761-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
T340761-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$939.90

a specific tubulin synthesis inhibitor and Topo I inhibitor

View related series

Apoptosis Microtubule/Tubulin

Basic Description

Synonyms	N-(1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide\|10-Demethoxy-10-methylthiocolchicine\|Acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-\|EINECS 220-346-8\|NCGC004854
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Thiocolchicine is an inhibitor of microtubules by specific binding to tubulin. Modulator of axonal cytoskeleton. Induces apoptosis. Topo I (topoisomerase I) inhibitor.

Associated Targets

TUBB1 Tclin Tubulin beta-1 chain 0 Activities

Discover Target: TUBB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TUBB2B Tclin Tubulin beta-2B chain 0 Activities

Discover Target: TUBB2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TUBA1A Tchem Tubulin alpha-1A chain 0 Activities

Discover Target: TUBA1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TOP2A Tclin DNA topoisomerase 2-alpha 0 Activities

Discover Target: TOP2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[(7S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
INCHI	InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChi Key	CMEGANPVAXDBPL-INIZCTEOSA-N
Canonical SMILES	CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC
Isomeric SMILES	CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC
RTECS	GH0878800
PubChem CID	17648
Molecular Weight	415.50

Certificates

Certificate of Analysis(COA)

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12 results found

Lot Number	Certificate Type	Date	Item
F2420406	Certificate of Analysis	Mar 01, 2024	T340761
F2420408	Certificate of Analysis	Mar 01, 2024	T340761
F2420410	Certificate of Analysis	Mar 01, 2024	T340761
F2420412	Certificate of Analysis	Mar 01, 2024	T340761
F2420415	Certificate of Analysis	Mar 01, 2024	T340761
F2420417	Certificate of Analysis	Mar 01, 2024	T340761
F2420420	Certificate of Analysis	Mar 01, 2024	T340761
F2420422	Certificate of Analysis	Mar 01, 2024	T340761
F2420424	Certificate of Analysis	Mar 01, 2024	T340761
F2420426	Certificate of Analysis	Mar 01, 2024	T340761
F2420428	Certificate of Analysis	Mar 01, 2024	T340761
F2420430	Certificate of Analysis	Mar 01, 2024	T340761

Solubility

Soluble in 100% ethanol, DMSO, methanol, and chloroform. Almost insoluble in water.

Refractive Index

n20D1.61 (Predicted)

Specific Rotation[α]

α20/D -229.1°, c = 0.35 in chloroform

Boil Point(°C)

729.06° C at 760 mmHg (Predicted)

Melt Point(°C)

154-158° C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS05
Signal	Danger
Hazard Statements	H318:Causes serious eye damage H300:Fatal if swallowed H330:Fatal if inhaled H340:May cause genetic defects H300+H330:Fatal if swallowed or if inhaled
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P320:Specific treatment is urgent (see ... on this label). P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P316:Get emergency medical help immediately.
RTECS	GH0878800

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