Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
Information
Thiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
Targets
SIRT2 (Cell-free assay) 28 nM
In vitro
Thiomyristoyl(TM) is a highly selective SIRT2 inhibitor. It cannot efficiently inhibit SIRT3, SIRT5, SIRT6, or SIRT7. it shows great inhibition of cell viability and its cytotoxicity is relatively selective toward cancer cells. TM decreases c-Myc oncoprotein level in cancer cells, the ability of TM to decrease c-Myc abundance in different cell lines correlates with the sensitivity of the cell lines to TM.
In vivo
The anticancer effect of TM correlates with its ability to decrease c-Myc level. TM has limited effects on non-cancerous cells and tumor-free mice.
Cell Research(from reference)
Cell lines：breast cancer cell lines MCF-7
Concentrations：1, 5, 10, 25, 50 μM
Incubation Time：6 h
Product Properties
ALogP
9.441
HBD Count
3
Rotatable Bond
24
Associated Targets(Human)
SIRT2TchemNAD-dependent protein deacetylase sirtuin-2 (6 Activities)
G2215694