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Thioperamide - ≥99%(HPLC), high purity , CAS No.106243-16-7, Antagonist of H 3 receptor;Antagonist of H 4 receptor
H3antagonist; also H4inverse agonist
Basic Description Synonyms Thioperamide|106243-16-7|MR-12842|Thioperamide maleate|MR 12842|N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide|1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-|II4319BWUI|CHEMBL260374|CHEBI:81391|N-Cyclohexyl-4-(1H-imidazol-5-y Specifications & Purity Moligand™, ≥99%(HPLC) Biochemical and Physiological Mechanisms Potent histamine H3and H4antagonist/inverse agonist. Kivalues are 25 and 27 nM for human recombinant H3and H4receptors respectively. Blocks eosinophil shape change (IC50= 1.4μM) and chemotaxis (IC50= 519 nM) induced by histamine. Freely crosses the blood- Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of H 3 receptor;Antagonist of H 4 receptor
Names and Identifiers IUPAC Name N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide INCHI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) InChi Key QKDDJDBFONZGBW-UHFFFAOYSA-N Canonical SMILES C1CCC(CC1)NC(=S)N2CCC(CC2)C3=CN=CN3 Isomeric SMILES C1CCC(CC1)NC(=S)N2CCC(CC2)C3=CN=CN3 PubChem CID 3035905 Molecular Weight 292.44
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 29.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 29.24, Max Conc. mM: 100
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