Thioridazine hydrochloride - 98%, high purity , Serotonin 2c (5-HT2c) receptor antagonist, CAS No.130-61-0, Serotonin 2c (5-HT2c) receptor antagonist

Item Number

T166901

• Synonyms: 10-(2-((2RS)-1-Methylpiperidin-2-yl)ethyl)-2-methylsulfanyl-10H-phenothiazine monohydrochloride | 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulfanyl)-10H-phenothiazine hydrochloride | Mellaril (TN) | NCGC00260347-01 | SR-01000000063 | Prestwick_437 |
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Dopamine receptor antagonist (K i values are 16 (D 2 ), 10 (D 1 ), 7.8 (D 3 ), and 31 (D 4 ) nM). Also inhibits CYP2D6 (IC 50 = 2.7 μM). Antipsychotic. Displays antituberculosis/ drug-resistant tuberculosis properties.
• Storage Temp: Protected from light,Room temperature
• Shipped In: Normal
• Action Type: ANTAGONIST
• Mechanism of action: Serotonin 2c (5-HT2c) receptor antagonist
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.