Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T275454-10mg | 10mg | In stock | $80.90 | |
T275454-25mg | 25mg | In stock | $181.90 | |
T275454-50mg | 50mg | In stock | $318.90 | |
T275454-100mg | 100mg | In stock | $572.90 |
Selective GAT-1 inhibitor
Synonyms | DB00906 | NO 328 | (-)-(r)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid | (R)-1-(4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid | 1006863-69-9 | HY-B0696 | (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3- |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | GABA uptake inhibitor, selective for GAT-1. Anticonvulsant in vivo . Also available in simple stock solutions add 1 ml of water to get an exact, ready-to-use concentration. |
Storage Temp | Store at 2-8°C,Desiccated |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of GAT1 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at 2-8°C;Keep sealing condition ,The product can be stored for up to 24 months. |
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IUPAC Name | (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid |
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INCHI | InChI=1S/C20H25NO2S2/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23)/t16-/m1/s1 |
InChi Key | PBJUNZJWGZTSKL-MRXNPFEDSA-N |
Canonical SMILES | CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C |
Isomeric SMILES | CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C |
Alternate CAS | 115103-54-3 |
PubChem CID | 60648 |
MeSH Entry Terms | (R)-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, hydrochloride;Gabitril;N-(4,4-di(3-methylthien-2-yl)but-3-enyl)nipecotic acid;NO 328;NO 329;NO-328;NO-329;tiagabine;Tiagabine Hydrochloride;tiagabine, (S)-isomer |
Molecular Weight | 375.55 |
DrugBank Ligand | DB00906 |
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Wikipedia | Tiagabine |
CAS Registry No. | 115103-54-3 |
PubChem CID | 60648 |
ChEMBL Ligand | CHEMBL1027 |
PEP | tiagabine |
DrugCentral Ligand | 2648 |
RCSB PDB Ligand | TGI, TGI |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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A2310167 | Certificate of Analysis | Oct 18, 2023 | T275454 |
A2310168 | Certificate of Analysis | Oct 18, 2023 | T275454 |
A2310185 | Certificate of Analysis | Oct 18, 2023 | T275454 |
A2310187 | Certificate of Analysis | Oct 18, 2023 | T275454 |
Solubility | Soluble in water to 25 mM and in 1 eq. NaOH to 100 mM |
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1. Raccuglia D & Mueller U. (2013) Focal uncaging of GABA reveals a temporally defined role for GABAergic inhibition during appetitive associative olfactory conditioning in honeybees.. Learn Mem, 20 (8): (410-6). [PMID:23860600] |
2. Rideau Batista Novais A et al.. (2014) Tiagabine improves hippocampal long-term depression in rat pups subjected to prenatal inflammation.. PLoS One, 9 (9): (e106302). [PMID:25184226] |