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Tiagabine - ≥99%, high purity , CAS No.115103-54-3, Inhibitor of GAT1

Specifications & Purity: ≥99%

CAS#: 115103-54-3
Formula: C₂₀H₂₅NO₂S₂
Molecular Weight: 375.55
PubChem CID: 60648

Item Number

T275454

Grouped product items
SKU	Size	Availability	Price
T275454-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$80.90
T275454-25mg	25mg	In stock	$181.90
T275454-50mg	50mg	In stock	$318.90
T275454-100mg	100mg	In stock	$572.90

Selective GAT-1 inhibitor

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GAT1 Inhibitor

Basic Description

Synonyms	tiagabine\|115103-54-3\|Gabitril\|(R)-Tiagabine\|Tiagabinum\|Tiagabina\|Gabatril\|Tiagabinum [INN-Latin]\|Tiagabina [INN-Spanish]\|Tiagabine [INN]\|Abbott-70569\|UNII-Z80I64HMNP\|Z80I64HMNP\|Tiagabine (INN)\|ABT-569 FREE BASE\|CHEBI:9586\|(-)-(R)-1-(4,4-Bis(3-methyl-2-th
Specifications & Purity	≥99%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of GAT1

Names and Identifiers

IUPAC Name	(3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
INCHI	InChI=1S/C20H25NO2S2/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23)/t16-/m1/s1
InChi Key	PBJUNZJWGZTSKL-MRXNPFEDSA-N
Canonical SMILES	CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C
Isomeric SMILES	CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C
Alternate CAS	115103-54-3
PubChem CID	60648
MeSH Entry Terms	(R)-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, hydrochloride;Gabitril;N-(4,4-di(3-methylthien-2-yl)but-3-enyl)nipecotic acid;NO 328;NO 329;NO-328;NO-329;tiagabine;Tiagabine Hydrochloride;tiagabine, (S)-isomer
Molecular Weight	375.55

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ChEMBL Ligand

PEP

DrugCentral Ligand

RCSB PDB Ligand

TGI, TGI

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4 results found

Lot Number	Certificate Type	Date	Item
A2310167	Certificate of Analysis	Oct 18, 2023	T275454
A2310168	Certificate of Analysis	Oct 18, 2023	T275454
A2310185	Certificate of Analysis	Oct 18, 2023	T275454
A2310187	Certificate of Analysis	Oct 18, 2023	T275454

References

1. Raccuglia D & Mueller U. (2013) Focal uncaging of GABA reveals a temporally defined role for GABAergic inhibition during appetitive associative olfactory conditioning in honeybees.. Learn Mem, 20 (8): (410-6). [PMID:23860600]
2. Rideau Batista Novais A et al.. (2014) Tiagabine improves hippocampal long-term depression in rat pups subjected to prenatal inflammation.. PLoS One, 9 (9): (e106302). [PMID:25184226]

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Tiagabine - ≥99%, high purity , CAS No.115103-54-3, Inhibitor of GAT1

Basic Description

Associated Targets

SLC6A1 Tclin Sodium- and chloride-dependent GABA transporter 1 1 Activities

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