Tianeptine - 10mM in DMSO, high purity , CAS No.72797-41-2

Item Number

T425686

• Synonyms: Tianeptine | 66981-73-5 | 72797-41-2 | Tianeptine [INN] | 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid | (+)-Tianeptine | (-)-Tianeptine | Tianeptine (INN) | Tianeptine, (+)- | Tianeptine, (-)- | AKU7QFL9ZT | TPI-1062 | Stablon (TN) |
• Specifications & Purity: 10mM in DMSO
• Biochemical and Physiological Mechanisms: Tianeptine (S-1574, JNJ-39823277, TPI-1062) is an antidepressant agent that act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors.
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

Tianeptine Tianeptine (S-1574, JNJ-39823277, TPI-1062) is an antidepressant agent that act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors.

Targets

5-HT ; μ-opioid receptor (for human μ-opioid receptor) ; 383 nM(Ki)

In vitro

Tianeptine modulates glutamatergic transmission. It restores stress-induced reduction of dendritic arborization in hippocampal neurons and reverses stress-induced inhibition of long-term potentiation at excitatory synapses in the hippocampus and prefrontal cortex. Tianeptine is a serotonin reuptake enhancer and has an antidepressant efficacy.

In vivo

In preclinical studies, tianeptine has beneficial effects in a number of behavioral models related to depression, anxiety and other stress-related disorders.