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Ticagrelor - ≥98%, high purity , Purinergic receptor P2Y12 negative allosteric modulator, CAS No.274693-27-5, Purinergic receptor P2Y12 negative allosteric modulator
Reversible P2Y 12 receptor antagonist
Basic Description Synonyms Ticagrelor|274693-27-5|Brilinta|Brilique|AZD6140|Possia|AZD-6140|AR-C126532XX|AZD 6140|TICARGRELOR|UNII-GLH0314RVC|GLH0314RVC|CHEBI:68558|(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimid Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Ticagrelor is an active drug which, does not require metabolic activation after intestinal absorption. It does not compete directly with ADP at the ADP binding site but occupies an adjacent binding site and acts in an allosteric way, resulting in a revers Storage Temp Protected from light,Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST, INHIBITOR, NEGATIVE ALLOSTERIC MODULATOR Mechanism of action Purinergic receptor P2Y12 negative allosteric modulator Product Description Ticagrelor(AZD-6140) is the first reversibly binding oral P2Y12 receptor antagonist(Ki= 2 nM), also inhibits CYP2C9 and midazolam 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively.
Names and Identifiers IUPAC Name (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol INCHI InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1 InChi Key OEKWJQXRCDYSHL-FNOIDJSQSA-N Canonical SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F Isomeric SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F PubChem CID 9871419 Molecular Weight 522.57
Chemical and Physical Properties Solubility DMSO 105 mg/mL Water <1 mg/mL Ethanol 53 mg/mL Sensitivity Light sensitive Refractive Index 1.74 Boil Point(°C) ~777.6 °C at 760 mmHg Melt Point(°C) 149-154°C
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H411: Toxic to aquatic life with long lasting effects
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P391: Collect spillage.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
References 1. Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG et al. . (2007) From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.. Bioorg Med Chem Lett, 17 (21): (6013-8). [PMID:17827008 ]
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