Potent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor (IC 50 = 250 nM). Anti- angiogenesis agent. Active in vivo and in vivo. Cell-permeable.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of TEK receptor tyrosine kinase
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M. (2007) Pyridinylimidazole inhibitors of Tie2 kinase.. Bioorg Med Chem Lett, 17 (17):(4756-60). [PMID:17618114][10.1021/op500134e]
3.Besnier M et al.. (2019) miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia.. Mol Ther Nucleic Acids, 17 (49-62). [PMID:31220779]
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D2313496