Tie2 kinase inhibitor - ≥97%, high purity , CAS No.948557-43-5, Inhibitor of TEK receptor tyrosine kinase

Item Number
T129823
Grouped product items
SKUSizeAvailabilityPrice Qty
T129823-5mg
5mg
In stock
$225.90
T129823-10mg
10mg
In stock
$375.90
T129823-25mg
25mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$846.90
T129823-50mg
50mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$969.90

Potent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable.

Basic Description

Synonyms948557-43-5 | Tie2 kinase inhibitor | Tie2 kinase inhibitor 1 | Tie2 kinase-IN-1 | Tie2-IN-5 | 4-(4-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine | CHEMBL237352 | 4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidaz
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsPotent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor (IC 50 = 250 nM). Anti- angiogenesis agent. Active in vivo and in vivo. Cell-permeable.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of TEK receptor tyrosine kinase
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

TEK Tclin Angiopoietin-1 receptor (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TEK Tclin Tyrosine-protein kinase TIE-2 (3348 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MOPC 315 (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488200358
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488200358
IUPAC Name 4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
INCHI InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29)
InChi Key SINQIEAULQKUPD-UHFFFAOYSA-N
Canonical SMILES COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5
Isomeric SMILES COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5
Alternate CAS 948557-43-5
PubChem CID 23625762
MeSH Entry Terms 4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
Molecular Weight 439.53

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
D2313496Certificate of AnalysisMar 03, 2023 T129823
D2313497Certificate of AnalysisMar 03, 2023 T129823
D2313498Certificate of AnalysisMar 03, 2023 T129823
D2313499Certificate of AnalysisMar 03, 2023 T129823
D2313503Certificate of AnalysisMar 03, 2023 T129823
D2313504Certificate of AnalysisMar 03, 2023 T129823
D2313505Certificate of AnalysisMar 03, 2023 T129823
D2313506Certificate of AnalysisMar 03, 2023 T129823

Chemical and Physical Properties

SolubilityDMSO 35 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

Related Documents

References

1. Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M.  (2007)  Pyridinylimidazole inhibitors of Tie2 kinase..  Bioorg Med Chem Lett,  17  (17): (4756-60).  [PMID:17618114]
2. Karabid NM et al..  (2022)  Angpt2/Tie2 autostimulatory loop controls tumorigenesis..  EMBO Mol Med,  14  (5): (e14364).  [PMID:35266635]
3. Besnier M et al..  (2019)  miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia..  Mol Ther Nucleic Acids,  17  (49-62).  [PMID:31220779]

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