Tie2 kinase inhibitor - ≥97%, high purity , CAS No.948557-43-5, Inhibitor of TEK receptor tyrosine kinase

Item Number

T129823

Grouped product items
SKU	Size	Availability	Price
T129823-5mg	5mg	In stock	$225.90
T129823-10mg	10mg	In stock	$375.90
T129823-25mg	25mg	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$846.90
T129823-50mg	50mg	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$969.90

Potent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable.

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Basic Description

Synonyms	948557-43-5\|Tie2 kinase inhibitor\|Tie2 kinase inhibitor 1\|Tie2 kinase-IN-1\|Tie2-IN-5\|4-(4-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine\|CHEMBL237352\|4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidaz
Specifications & Purity	≥97%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of TEK receptor tyrosine kinase

Names and Identifiers

Pubchem Sid	488200358
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488200358
IUPAC Name	4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
INCHI	InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29)
InChi Key	SINQIEAULQKUPD-UHFFFAOYSA-N
Canonical SMILES	COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5
Isomeric SMILES	COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5
Alternate CAS	948557-43-5
PubChem CID	23625762
MeSH Entry Terms	4-(6-methoxy-2-naphthyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
Molecular Weight	439.53

Certificates

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8 results found

Lot Number	Certificate Type	Date	Item
D2313496	Certificate of Analysis	Mar 03, 2023	T129823
D2313497	Certificate of Analysis	Mar 03, 2023	T129823
D2313498	Certificate of Analysis	Mar 03, 2023	T129823
D2313499	Certificate of Analysis	Mar 03, 2023	T129823
D2313503	Certificate of Analysis	Mar 03, 2023	T129823
D2313504	Certificate of Analysis	Mar 03, 2023	T129823
D2313505	Certificate of Analysis	Mar 03, 2023	T129823
D2313506	Certificate of Analysis	Mar 03, 2023	T129823

References

1. Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M. (2007) Pyridinylimidazole inhibitors of Tie2 kinase.. Bioorg Med Chem Lett, 17 (17): (4756-60). [PMID:17618114]
2. Karabid NM et al.. (2022) Angpt2/Tie2 autostimulatory loop controls tumorigenesis.. EMBO Mol Med, 14 (5): (e14364). [PMID:35266635]
3. Besnier M et al.. (2019) miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia.. Mol Ther Nucleic Acids, 17 (49-62). [PMID:31220779]

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Basic Description