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SKU | Size | Availability | Price | Qty |
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T467756-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $70.90 |
Synonyms | FT-0656019 | s5020 | 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride | Tilorone Hydrochloride (USAN) | AMY10986 | TILORONE DIHYDROCHLORIDE [MI] | J-016822 | 2,7-Bis[2-(diethylamino)ethoxy]fluoren-9-one dihydrochloride | 2,7-Bis[2-(diethylamin |
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Specifications & Purity | ≥95% |
Product Description | Description Effect of tilorone dihydrochloride on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been investigated. Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent.Tilorone dihydrochloride was used to study the interaction of drugs with synthetic self-complementary DNA by SPR (Surface Plasmon Resonance). |
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IUPAC Name | 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride |
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INCHI | InChI=1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H |
InChi Key | BSVYJQAWONIOOU-UHFFFAOYSA-N |
Canonical SMILES | CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC.Cl.Cl |
Isomeric SMILES | CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC.Cl.Cl |
WGK Germany | 3 |
RTECS | LL9000000 |
Alternate CAS | 27591-97-5 |
PubChem CID | 33958 |
Molecular Weight | 483.47 |
Reaxy-Rn | 5683048 |
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Melt Point(°C) | 230-233°C |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H351:Suspected of causing cancer H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | LL9000000 |
Reaxy-Rn | 5683048 |
Merck Index | 9440 |
1. H M Burke,M M Joullié. (1978-10-01) New synthetic routes to tilorone dihydrochloride and some of its analogues.. Journal of medicinal chemistry, 21 ((10)): (1084-1086). [PMID:722716] |
2. I V Tkachenko,E G Garkavaia,A V Karpov. (2006-06-09) [Allergenic and immunotropic properties of yeast RNA-tilorone hydrochloride molecular complex].. Zhurnal mikrobiologii, epidemiologii, i immunobiologii, ((2)(2)): (70-74). [PMID:16758904] |
3. N Ya Golovenko,I Yu Borisyuk. (2006-07-20) Pharmacokinetics of amixin after repeated peroral administration to mice.. Bulletin of experimental biology and medicine, 140 ((6)): (708-710). [PMID:16848231] |
4. C A Briggs,M R Schrimpf,D J Anderson,E J Gubbins,J H Grønlien,M Håkerud,H Ween,K Thorin-Hagene,J Malysz,J Li,W H Bunnelle,M Gopalakrishnan,M D Meyer. (2007-12-25) alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues.. British journal of pharmacology, 153 ((5)): (1054-1061). [PMID:18157163] |
5. Tehila Mayer-Sonnenfeld,Dana Avrahami,Yael Friedman-Levi,Ruth Gabizon. (2008-03-20) Chemically induced accumulation of GAGs delays PrP(Sc) clearance but prolongs prion disease incubation time.. Cellular and molecular neurobiology, 28 ((7)): (1005-1015). [PMID:18350378] |
6. Rajiv R Ratan,Ambreena Siddiq,Leila Aminova,Brett Langley,Stephen McConoughey,Ksenia Karpisheva,Hsin-Hwa Lee,Thomas Carmichael,Harley Kornblum,Giovanni Coppola,Daniel H Geschwind,Ahmet Hoke,Natalya Smirnova,Cameron Rink,Sashwati Roy,Chandan Sen,Michael S Beattie,Ron P Hart,Martin Grumet,Dongming Sun,Robert S Freeman,Gregg L Semenza,Irina Gazaryan. (2008-12-17) Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.. Annals of the New York Academy of Sciences, 1147 (383-394). [PMID:19076458] |
7. Xianhua Zhang,Jingli Duan,Suodi Zhai,Yiheng Yang,Li Yang. (2010-01-02) Performance of tiloronoxim and tilorone determination in human blood by HPLC-MS/MS: method validation, uncertainty assessment and its application to a pharmacokinetic study.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878 ((3-4)): (492-496). [PMID:20044316] |
8. N V Kungurov,N M Gerasimova,N I Skidan,A P Gorbunov,N P Evstigneeva. (2011-01-25) [Open population comparative randomized clinical trial of lavomax efficacy and safety in combined treatment of non-gonococcal urethritis].. Urologiia (Moscow, Russia : 1999), ((5)(5)): (46-52). [PMID:21254641] |
9. N M Zholobak,N S Kavok,O S Bogorad-Kobelska,I A Borovoy,M Yu Malyukina,M Ya Spivak. (2012-08-10) Effect of tilorone and its analogues on the change of mitochondrial potential of rat hepatocytes.. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 58 ((2)): (39-43). [PMID:22873051] |
10. G V Antonovych,N M Zholobak,S A Lyakhov,M O Shibinska,S A Andronati,M Y Spivak. (2012-10-24) Dose-dependent IFN-stimulating and immunomodulating properties of 6H-indolo[2,3-B] quinoxaline derivatives.. Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 74 ((4)): (79-86). [PMID:23088104] |
11. M G Romantsov,Kh M Galimzianov,O M Lokteva,A L Kovalenko,A V Stepanov. (2013-01-29) [Experimental and clinicolaboratory evaluation of complex therapy efficacy in arboviral infections].. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 57 ((7-8)): (12-22). [PMID:23350190] |
12. Tapan Biswas,Keith D Green,Sylvie Garneau-Tsodikova,Oleg V Tsodikov. (2013-09-06) Discovery of inhibitors of Bacillus anthracis primase DnaG.. Biochemistry, 52 ((39)): (6905-6910). [PMID:24004110] |
13. Liangmei Chen,Fei Wang. (2013-11-28) Development of sustained-release matrix tablets of BKP-01-041 (tilorone derivative) containing Hypromellose.. Die Pharmazie, 68 ((10)): (796-799). [PMID:24273882] |
14. G Bischoff,R Bischoff,E Birch-Hirschfeld,U Gromann,S Lindau,W V Meister,S de A Bambirra,C Bohley,S Hoffmann. (1998-12-02) DNA-drug interaction measurements using surface plasmon resonance.. Journal of biomolecular structure & dynamics, 16 ((2)): (187-203). [PMID:9833660] |
15. Tomoki Nishimura,Tadashi Okobira,Andrew M Kelly,Naohiko Shimada,Yoichi Takeda,Kazuo Sakurai. (2007-06-19) DNA binding of tilorone: 1H NMR and calorimetric studies of the intercalation.. Biochemistry, 46 ((27)): (8156-8163). [PMID:17571857] |
16. Vladimir G Zinkovsky,Olga V Zhuk,Svetlana K Sumriy. (2008-01-16) Pharmacokinetics of a synthetic interferon inducer amixin in mice.. Pharmacological reports : PR, 59 ((6)): (739-751). [PMID:18195465] |
17. Xianhua Zhang,Li Yang,Suodi Zhai,Jingli Duan. (2008-10-10) Simultaneous quantification of tiloronoxim and tilorone in human urine by liquid chromatography-tandem mass spectrometry.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 875 ((2)): (349-357). [PMID:18842466] |
18. G P Potebnya,G S Lisovenko,N V Trokhimenko,N L Cheremshenko,G V Didenko,A S Reder,S A Andronati. (2008-12-30) Elevation of efficacy of cancer vaccine combined with interferon and inducer of endogeneous interferon synthesis amixin.. Experimental oncology, 30 ((4)): (319-323). [PMID:19112431] |
19. Michael R Schrimpf,Kevin B Sippy,Clark A Briggs,David J Anderson,Tao Li,Jianguo Ji,Jennifer M Frost,Carol S Surowy,William H Bunnelle,Murali Gopalakrishnan,Michael D Meyer. (2012-01-28) SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.. Bioorganic & medicinal chemistry letters, 22 ((4)): (1633-1638). [PMID:22281189] |
20. V A Isakov,D K Ermolenko,D V Isakov. (2012-02-09) [Perspectives of prevention and treatment of herpes symplex with regular recurrence].. Terapevticheskii arkhiv, 83 ((11)): (44-47). [PMID:22312884] |
21. Outi Leppäranta,Jussi M Tikkanen,Maxim M Bespalov,Katri Koli,Marjukka Myllärniemi. (2012-12-22) Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo.. American journal of respiratory cell and molecular biology, 48 ((4)): (448-455). [PMID:23258233] |
22. Mahsa Alem,Amir Ali Shahbazfar,Payman Zare,Hossein Tayefi-Nasrabadi. (2019-03-19) The effects of coadministration of tilorone dihydrochloride and culture supernatants from Lactobacillus reuteri on the mouse hepatoma cell line.. Journal of cancer research and therapeutics, 15 ((1)): (176-184). [PMID:30880776] |
23. Lyndsey Elaine Gates,Ahmed Abdeen Hamed. (2020-08-01) The Anatomy of the SARS-CoV-2 Biomedical Literature: Introducing the CovidX Network Algorithm for Drug Repurposing Recommendation.. Journal of medical Internet research, 22 ((8)): (e21169-e21169). [PMID:32735546] |