Tilorone dihydrochloride - 95%, high purity , CAS No.27591-69-1

  • ≥95%
Item Number
T467756
Grouped product items
SKUSizeAvailabilityPrice Qty
T467756-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$70.90

Basic Description

SynonymsFT-0656019 | s5020 | 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride | Tilorone Hydrochloride (USAN) | AMY10986 | TILORONE DIHYDROCHLORIDE [MI] | J-016822 | 2,7-Bis[2-(diethylamino)ethoxy]fluoren-9-one dihydrochloride | 2,7-Bis[2-(diethylamin
Specifications & Purity≥95%
Product Description

Description

Effect of tilorone dihydrochloride on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been investigated. Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent.Tilorone dihydrochloride was used to study the interaction of drugs with synthetic self-complementary DNA by SPR (Surface Plasmon Resonance).

Associated Targets(Human)

A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

gag-pol Moloney murine leukaemia virus Pol protein (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vesicular stomatitis virus (4460 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L929 (3802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one;dihydrochloride
INCHI InChI=1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H
InChi Key BSVYJQAWONIOOU-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC.Cl.Cl
Isomeric SMILES CCN(CC)CCOC1=CC2=C(C=C1)C3=C(C2=O)C=C(C=C3)OCCN(CC)CC.Cl.Cl
WGK Germany 3
RTECS LL9000000
Alternate CAS 27591-97-5
PubChem CID 33958
Molecular Weight 483.47
Reaxy-Rn 5683048

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Melt Point(°C)230-233°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H351:Suspected of causing cancer

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS LL9000000
Reaxy-Rn 5683048
Merck Index 9440

Related Documents

References

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10. G V Antonovych,N M Zholobak,S A Lyakhov,M O Shibinska,S A Andronati,M Y Spivak.  (2012-10-24)  Dose-dependent IFN-stimulating and immunomodulating properties of 6H-indolo[2,3-B] quinoxaline derivatives..  Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993),  74  ((4)): (79-86).  [PMID:23088104]
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13. Liangmei Chen,Fei Wang.  (2013-11-28)  Development of sustained-release matrix tablets of BKP-01-041 (tilorone derivative) containing Hypromellose..  Die Pharmazie,  68  ((10)): (796-799).  [PMID:24273882]
14. G Bischoff,R Bischoff,E Birch-Hirschfeld,U Gromann,S Lindau,W V Meister,S de A Bambirra,C Bohley,S Hoffmann.  (1998-12-02)  DNA-drug interaction measurements using surface plasmon resonance..  Journal of biomolecular structure & dynamics,  16  ((2)): (187-203).  [PMID:9833660]
15. Tomoki Nishimura,Tadashi Okobira,Andrew M Kelly,Naohiko Shimada,Yoichi Takeda,Kazuo Sakurai.  (2007-06-19)  DNA binding of tilorone: 1H NMR and calorimetric studies of the intercalation..  Biochemistry,  46  ((27)): (8156-8163).  [PMID:17571857]
16. Vladimir G Zinkovsky,Olga V Zhuk,Svetlana K Sumriy.  (2008-01-16)  Pharmacokinetics of a synthetic interferon inducer amixin in mice..  Pharmacological reports : PR,  59  ((6)): (739-751).  [PMID:18195465]
17. Xianhua Zhang,Li Yang,Suodi Zhai,Jingli Duan.  (2008-10-10)  Simultaneous quantification of tiloronoxim and tilorone in human urine by liquid chromatography-tandem mass spectrometry..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  875  ((2)): (349-357).  [PMID:18842466]
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19. Michael R Schrimpf,Kevin B Sippy,Clark A Briggs,David J Anderson,Tao Li,Jianguo Ji,Jennifer M Frost,Carol S Surowy,William H Bunnelle,Murali Gopalakrishnan,Michael D Meyer.  (2012-01-28)  SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore..  Bioorganic & medicinal chemistry letters,  22  ((4)): (1633-1638).  [PMID:22281189]
20. V A Isakov,D K Ermolenko,D V Isakov.  (2012-02-09)  [Perspectives of prevention and treatment of herpes symplex with regular recurrence]..  Terapevticheskii arkhiv,  83  ((11)): (44-47).  [PMID:22312884]
21. Outi Leppäranta,Jussi M Tikkanen,Maxim M Bespalov,Katri Koli,Marjukka Myllärniemi.  (2012-12-22)  Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo..  American journal of respiratory cell and molecular biology,  48  ((4)): (448-455).  [PMID:23258233]
22. Mahsa Alem,Amir Ali Shahbazfar,Payman Zare,Hossein Tayefi-Nasrabadi.  (2019-03-19)  The effects of coadministration of tilorone dihydrochloride and culture supernatants from Lactobacillus reuteri on the mouse hepatoma cell line..  Journal of cancer research and therapeutics,  15  ((1)): (176-184).  [PMID:30880776]
23. Lyndsey Elaine Gates,Ahmed Abdeen Hamed.  (2020-08-01)  The Anatomy of the SARS-CoV-2 Biomedical Literature: Introducing the CovidX Network Algorithm for Drug Repurposing Recommendation..  Journal of medical Internet research,  22  ((8)): (e21169-e21169).  [PMID:32735546]

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