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tiludronic acid , CAS No.89987-06-4, Inhibitor of MMP2

CAS#: 89987-06-4
Formula: C₇H₉ClO₆P₂S
Molecular Weight: 318.61
EC Number: 618-322-0
PubChem CID: 60937

Item Number

T614454

Grouped product items
SKU	Size	Availability	Price	Qty
T614454-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$620.90
T614454-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,817.90

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MMP2 Inhibitor

Basic Description

Synonyms	Tiludronic Acid \| Tiludronate \| 89987-06-4 \| Acide tiludronique [INN-French] \| Acido tiludronico [INN-Spanish] \| Acidum tiludronicum [INN-Latin] \| SR-41319 \| [(4-chlorophenyl)sulfanyl-phosphonomethyl]phosphonic acid \| SR 41319 \| 6PNS59HP4Y \| CHEBI:9598 \| Tiludronic acid (INN) \|
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of MMP2

Associated Targets(Human)

MMP2 Tchem 72 kDa type IV collagenase (1 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

Discover Target: MMP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP14 Tchem Matrix metalloproteinase 14 (1592 Activities)

Discover Target: MMP14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hydroxyapatite (165 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Discover Target: Mmp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[(4-chlorophenyl)sulfanyl-phosphonomethyl]phosphonic acid
INCHI	InChI=1S/C7H9ClO6P2S/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14/h1-4,7H,(H2,9,10,11)(H2,12,13,14)
InChi Key	DKJJVAGXPKPDRL-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1SC(P(=O)(O)O)P(=O)(O)O)Cl
Isomeric SMILES	C1=CC(=CC=C1SC(P(=O)(O)O)P(=O)(O)O)Cl
Alternate CAS	89987-06-4,149845-07-8 (disodium)
PubChem CID	60937
MeSH Entry Terms	(4-chlorophenyl)thiomethylene bisphosphonic acid;(chloro-4-phenyl)thiomethylene biphosphonate;(chloro-4-phenyl)thiomethylene bisphosphonate;Cl2SMBP;Skelid;tiludronate;tiludronate disodium;tiludronic acid
Molecular Weight	318.61

PubChem CID

CAS Registry No.

ChEMBL Ligand

DrugBank Ligand

Wikipedia

PEP

DrugCentral Ligand

References

1. Tauro M, Laghezza A, Loiodice F, Agamennone M, Campestre C, Tortorella P. (2013) Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors.. Bioorg Med Chem, 21 (21): (6456-65). [PMID:24071448]
2. Reginster JY, Jeugmans-Huynen AM, Albert A, Denis D, Deroisy R, Lecart MP, Fontaine MA, Collette J, Franchimont P. (1988) Biological and clinical assessment of a new bisphosphonate, (chloro-4 phenyl) thiomethylene bisphosphonate, in the treatment of Paget's disease of bone.. Bone, 9 (6): (349-54). [PMID:3073800]

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tiludronic acid , CAS No.89987-06-4, Inhibitor of MMP2

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

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Certificates

Certificate of Analysis(COA)

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References

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