Tipiracil hydrochloride - 10mM in DMSO, high purity , CAS No.183204-72-0

  • 10mM in DMSO
Item Number
T422250
Grouped product items
SKUSizeAvailabilityPrice Qty
T422250-1ml
1ml
Available within 4-8 weeks(?)
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$69.90

Phosphorylase Inhibitors

Basic Description

SynonymsTipiracil hydrochloride | 183204-72-0 | Tipiracil HCl | Tipiracil (hydrochloride) | Tipiracil hydrochloride [USAN] | TAS-1-462 | 4H59KLQ0A4 | 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride | CHEMBL65375 | MA-1 hydrochloride | TPI | UNII-4H
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsTipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Information

Tipiracil hydrochloride Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase , the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.

Targets

thymidine phosphorylase

Product Properties

ALogP-0.388
HBD Count2
Rotatable Bond2

Associated Targets(Human)

TYMP Tclin Thymidine phosphorylase (12 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HUVEC (11049 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

deoA Thymidine phosphorylase (531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione;hydrochloride
INCHI InChI=1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
InChi Key KGHYQYACJRXCAT-UHFFFAOYSA-N
Canonical SMILES C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.Cl
Isomeric SMILES C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.Cl
PubChem CID 9903778
Molecular Weight 279.12

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

DMSO(mg / mL) Max Solubility8
DMSO(mM) Max Solubility28.6615076
Water(mg / mL) Max Solubility55
Water(mM) Max Solubility197.0478647

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

Solution Calculators