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Tipiracil hydrochloride - 10mM in DMSO, high purity , CAS No.183204-72-0
Basic Description Synonyms Tipiracil hydrochloride | 183204-72-0 | Tipiracil HCl | Tipiracil (hydrochloride) | Tipiracil hydrochloride [USAN] | TAS-1-462 | 4H59KLQ0A4 | 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride | CHEMBL65375 | MA-1 hydrochloride | TPI | UNII-4H Specifications & Purity 10mM in DMSO Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
Tipiracil hydrochloride Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase , the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.
Targets
thymidine phosphorylase
Product Properties ALogP -0.388 HBD Count 2 Rotatable Bond 2
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione;hydrochloride INCHI InChI=1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H InChi Key KGHYQYACJRXCAT-UHFFFAOYSA-N Canonical SMILES C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.Cl Isomeric SMILES C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl.Cl PubChem CID 9903778 Molecular Weight 279.12
Chemical and Physical Properties DMSO(mg / mL) Max Solubility 8 DMSO(mM) Max Solubility 28.6615076 Water(mg / mL) Max Solubility 55 Water(mM) Max Solubility 197.0478647
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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