Click Here for 5% Off Your First Aladdin Purchase!

TL1A, CAS No.rp175308, death receptor 3

  • Moligand™
Features and benefits
    Item Number
    rp175308
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp175308-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp175308-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90
    View related series
    death receptor 3

    Basic Description

    Product NameTL1A, CAS No.rp175308
    SynonymsTumor necrosis factor ligand superfamily member 15, membrane form
    GradeMoligand™
    Mechanism of actiondeath receptor 3

    Associated Targets

    TNFRSF25 Tbio Tumor necrosis factor receptor superfamily member 25 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp175308

    Certificates

    Certificate of Analysis(COA)

    Enter Lot Number to search for COA:

    Genetic information

    Alternate NamesTumor necrosis factor ligand superfamily member 15, membrane form
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Kakuta Y, Kinouchi Y, Negoro K, Takahashi S, Shimosegawa T.  (2006)  Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease..  Gut,  55  (10): (1527-8).  [PMID:16966713]
    2. Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JI.  (2007)  TNFSF15 is an ethnic-specific IBD gene..  Inflamm Bowel Dis,  13  (11): (1333-8).  [PMID:17663424]
    3. Lagou S, Grapsa D, Syrigos N, Bamias G.  (2022)  The Role of Decoy Receptor DcR3 in Gastrointestinal Malignancy..  Cancer Diagn Progn,  (4): (411-421).  [PMID:35813013]
    4. Danese S, Klopocka M, Scherl EJ, Romatowski J, Allegretti JR, Peeva E, Vincent MS, Schoenbeck U, Ye Z, Hassan-Zahraee M et al..  (2021)  Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study..  Clin Gastroenterol Hepatol,  19  (11): (2324-2332.e6).  [PMID:34126262]
    5. Zhang T, Ning WW, Zhang J, Xu FJ, Wang XQ, Li ZB, Xie M.  (2022)  Nonylphenol regulates TL1A through the AhR/HDAC2/HNF4α pathway in endothelial cells to promote the angiogenesis of colorectal cancer..  Toxicol Appl Pharmacol,  436  (3): (115854).  [PMID:34974051]
    6. Gao Y, Wang Y, Wang X, Wang Y, Zhang X, Sun X.  (2019)  TNF-like ligand 1A is associated with progression and prognosis of human gastric cancer..  Onco Targets Ther,  12  (3): (7715-7723).  [PMID:31571922]
    7. Banfield C, Rudin D, Bhattacharya I, Goteti K, Li G, Hassan-Zahraee M, Brown LS, Hung KE, Pawlak S, Lepsy C.  (2020)  First-in-human, randomized dose-escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF-06480605 in healthy subjects..  Br J Clin Pharmacol,  86  (4): (812-824).  [PMID:31758576]

    Solution Calculators