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TLR7/8/9-IN-1 - 99%, high purity , CAS No.2180127-82-4

≥99%

CAS#: 2180127-82-4
Formula: C₂₇H₃₇N₃O₂
Molecular Weight: 435.60
PubChem CID: 134230357

Item Number

T646365

Grouped product items
SKU	Size	Availability	Price
T646365-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$320.90
T646365-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$510.90
T646365-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,050.90

View related series

Immunology/Inflammation Toll-like Receptor (TLR)

Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist ( IC 50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9) .
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist ( IC 50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9) . Form:Solid

Associated Targets(Human)

TLR8 Tchem Toll-like receptor 8 (2 Activities)

Discover Target: TLR8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TLR9 Tclin Toll-like receptor 9 (4 Activities)

Discover Target: TLR9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TLR7 Tclin Toll-like receptor 7 (4 Activities)

Discover Target: TLR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TLR4 Tchem Toll-like receptor 4 (970 Activities)

Discover Target: TLR4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TLR8 Tchem Toll-like receptor 8 (1853 Activities)

Discover Target: TLR8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tlr7 Toll-like receptor 7 (174 Activities)

Discover Target: Tlr7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tlr9 Toll-like receptor 9 (360 Activities)

Discover Target: Tlr9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[4-[2-(3,4-dimethoxyphenyl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
INCHI	InChI=1S/C27H37N3O2/c1-18(2)26-22-16-20(19-10-13-30(14-11-19)15-12-28-3)6-8-23(22)29-27(26)21-7-9-24(31-4)25(17-21)32-5/h6-9,16-19,28-29H,10-15H2,1-5H3
InChi Key	UKYUETHIPBXYBQ-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=C(NC2=C1C=C(C=C2)C3CCN(CC3)CCNC)C4=CC(=C(C=C4)OC)OC
Isomeric SMILES	CC(C)C1=C(NC2=C1C=C(C=C2)C3CCN(CC3)CCNC)C4=CC(=C(C=C4)OC)OC
PubChem CID	134230357
Molecular Weight	435.60

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TLR7/8/9-IN-1 - 99%, high purity , CAS No.2180127-82-4

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

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