TMCB - ≥98%, high purity , CAS No.905105-89-7, Inhibitor of casein kinase 2; alpha 1 polypeptide subunit;Inhibitor of casein kinase 2; alpha prime polypeptide subunit
TMCB - ≥98%, high purity , CAS No.905105-89-7, Inhibitor of casein kinase 2; alpha 1 polypeptide subunit;Inhibitor of casein kinase 2; alpha prime polypeptide subunit
GTPL8140 | TMCB | CK2/ERK8-IN-1 | Casein Kinase II Inhibitor VI | 2-[4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazol-1-yl]acetic acid | [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid | 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-be
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
CK2 inhibitor (K i = 0.25 μM), more selective than DMAT. Unlike DMAT, TMCB displays selectivity over PIM1, HIPK2 and DYRK1a (K i values are 8.65, 15.25 and 11.90 μM, respectively) and a more favourable selectivity profile over a range of other kinases.
Storage Temp
Room temperature
Shipped In
Normal
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of casein kinase 2; alpha 1 polypeptide subunit;Inhibitor of casein kinase 2; alpha prime polypeptide subunit
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at Room Temperature. The product can be stored for up to 12 months.
Associated Targets(Human)
CSNK2A2TchemCasein kinase II subunit alpha' (2 Activities)
1.Janeczko M, Orzeszko A, Kazimierczuk Z, Szyszka R, Baier A. (2012) CK2α and CK2α' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives.. Eur J Med Chem, 47 (1):(345-50). [PMID:22115617]
2.Smith MC et al.. (2011) CK2 inhibitors increase the sensitivity of HSV-1 to interferon-ß.. Antiviral Res, 91 (3):(259-66). [PMID:21722672]
3.Tsai CN et al.. (2019) Serine 229 Balances the Hepatitis C Virus Nonstructural Protein NS5A between Hypo- and Hyperphosphorylated States.. J Virol, 93 (23):[PMID:31511391]
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