TMCB - ≥98%, high purity , CAS No.905105-89-7, Inhibitor of casein kinase 2; alpha 1 polypeptide subunit;Inhibitor of casein kinase 2; alpha prime polypeptide subunit

Item Number

T275633

Grouped product items
SKU	Size	Availability	Price	Qty
T275633-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$109.90
T275633-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$454.90

Selective CK2 inhibitor

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Basic Description

Synonyms	TMCB\|905105-89-7\|1085822-09-8\|CK2/ERK8-IN-1\|4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzimidazole-1-acetic acid\|[4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid\|CHEMBL1233807\|compound 2c [PMID: 22115617]\|2-[4,5,6,7-tetrabromo-2-(dime
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	CK2 inhibitor (K i = 0.25 μM), more selective than DMAT. Unlike DMAT, TMCB displays selectivity over PIM1, HIPK2 and DYRK1a (K i values are 8.65, 15.25 and 11.90 μM, respectively) and a more favourable selectivity profile over a range of other kinases.
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of casein kinase 2; alpha 1 polypeptide subunit;Inhibitor of casein kinase 2; alpha prime polypeptide subunit
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Store at Room Temperature. The product can be stored for up to 12 months.

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazol-1-yl]acetic acid
INCHI	InChI=1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20)
InChi Key	PHAOTASRLQMKBE-UHFFFAOYSA-N
Canonical SMILES	CN(C)C1=NC2=C(N1CC(=O)O)C(=C(C(=C2Br)Br)Br)Br
Isomeric SMILES	CN(C)C1=NC2=C(N1CC(=O)O)C(=C(C(=C2Br)Br)Br)Br
PubChem CID	46943415
Molecular Weight	534.82

References

1. Janeczko M, Orzeszko A, Kazimierczuk Z, Szyszka R, Baier A. (2012) CK2α and CK2α' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives.. Eur J Med Chem, 47 (1): (345-50). [PMID:22115617]
2. Smith MC et al.. (2011) CK2 inhibitors increase the sensitivity of HSV-1 to interferon-ß.. Antiviral Res, 91 (3): (259-66). [PMID:21722672]
3. Tsai CN et al.. (2019) Serine 229 Balances the Hepatitis C Virus Nonstructural Protein NS5A between Hypo- and Hyperphosphorylated States.. J Virol, 93 (23): [PMID:31511391]

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Basic Description