TMP195 - 98%, high purity , CAS No.1314891-22-9

Item Number

T414032

• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

TMP195 TMP195 (TFMO 2) is a selective, first-in-class, class IIa HDAC inhibitor with IC50 of 300 nM in cell-based class IIa HDAC assays.

Targets

HDAC9 (Cell-free assay); HDAC7 (Cell-free assay); HDAC4 (Cell-free assay); HDAC5 (Cell-free assay) 15 nM(Ki); 26 nM(Ki); 59 nM(Ki); 60 nM(Ki)

In vitro

TMP195 has low potency in recombinant class I and IIb HDAC assays, enabling full inhibition of class IIa HDAC activity without inhibition of other HDACs. TMP195 blocks the accumulation of CCL2 protein in the supernatants of monocyte-derived macrophage differentiation cultures and significantly increases the amount of CCL1 protein secreted by the monocytes compared to vehicle (DMSO)-treated M-CSF plus GM-CSF cultures. TMP195 influences human monocyte responses to the colony-stimulating factors CSF-1 and CSF-2 in vitro.

In vivo

In vivo TMP195 treatment alters the tumour microenvironment and reduces tumour burden and pulmonary metastases by modulating macrophage phenotypes. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumours. TMP195 treatment significantly decreases proliferating tumour cells, most notably at the leading edge of the tumour. The anti-tumour macrophage phenotype induced by TMP195 treatment thus enhances the efficacy and durability of both standard chemotherapeutic regimens and checkpoint blockade immunotherapy in this mouse model of breast cancer.

Cell Research(from reference)

Cell lines：Human monocytes 

Concentrations：300 nM 

Incubation Time：5 days