The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
TN-16 - 98%, high purity , CAS No.33016-12-5
an antitumor drug that blocks microtubule assembly
Basic Description Synonyms tn-16|33016-12-5|3-(1-Anilinoethylidene)-5-benzylpyrrolidine-2,4-dione|TN 16|MLS002703542|(3Z)-3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione|CID 5354005|2,4-Pyrrolidinedione, 3-(1-anilinoethylidene)-5-benzyl-|SMR001570259|(E)-5-benzyl-3-(1-(phenyl Specifications & Purity ≥98% Biochemical and Physiological Mechanisms 3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase.It is a colchicine site binding agent and a powerful autophagy flux inhibitor tha Storage Temp Store at 2-8°C,Argon charged Shipped In Wet ice Product Description TN-16 is a synthetic antitumor drug that blocks microtubule assembly by binding to the colchicine site of Tubulin. TN-16 prevents stabilization of microtubules in Paclitaxel-treated cells. The compound also blocks the cell cycle in M phase.
Names and Identifiers IUPAC Name 2-benzyl-3-hydroxy-4-(C-methyl-N-phenylcarbonimidoyl)-1,2-dihydropyrrol-5-one INCHI InChI=1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,22H,12H2,1H3,(H,21,23) InChi Key IHXKJZIDPGITHW-UHFFFAOYSA-N Canonical SMILES CC(=NC1=CC=CC=C1)C2=C(C(NC2=O)CC3=CC=CC=C3)O Isomeric SMILES CC(=NC1=CC=CC=C1)C2=C(C(NC2=O)CC3=CC=CC=C3)O WGK Germany 3 PubChem CID 135427136 Molecular Weight 306.36
Chemical and Physical Properties Solubility Soluble in DMSO (25 mg/ml), warm ethanol (12.5 mg/ml), and DMF. Sensitivity Heat & Air sensitive Refractive Index n20D1.65 (Predicted) Boil Point(°C) 532.69° C at 760 mmHg (Predicted) Melt Point(°C) 182-185° C
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H317: May cause an allergic skin reaction
H400: Very toxic to aquatic life
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P391: Collect spillage.
WGK Germany 3 RIDADR UN30779/PGIII
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
F2316843