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TN-16 - 98%, high purity , CAS No.33016-12-5
an antitumor drug that blocks microtubule assembly
Basic Description Synonyms NSC100445 | NSC-100445 | SCHEMBL6739845 | SMR001570259 | tn-16 | (3Z)-3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione | HY-119357 | (3Z)-3-(1-anilinoethylidene)-5-benzyl-pyrrolidine-2,4-quinone | AC-35569 | Benzenepropanoic acid, 3-((dimethylaminome Specifications & Purity ≥98% Biochemical and Physiological Mechanisms 3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase.It is a colchicine site binding agent and a powerful autophagy flux inhibitor tha Storage Temp Store at 2-8°C,Argon charged Shipped In Wet ice Product Description TN-16 is a synthetic antitumor drug that blocks microtubule assembly by binding to the colchicine site of Tubulin. TN-16 prevents stabilization of microtubules in Paclitaxel-treated cells. The compound also blocks the cell cycle in M phase.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-benzyl-3-hydroxy-4-(C-methyl-N-phenylcarbonimidoyl)-1,2-dihydropyrrol-5-one INCHI InChI=1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,22H,12H2,1H3,(H,21,23) InChi Key IHXKJZIDPGITHW-UHFFFAOYSA-N Canonical SMILES CC(=NC1=CC=CC=C1)C2=C(C(NC2=O)CC3=CC=CC=C3)O Isomeric SMILES CC(=NC1=CC=CC=C1)C2=C(C(NC2=O)CC3=CC=CC=C3)O WGK Germany 3 PubChem CID 135427136 Molecular Weight 306.36
Chemical and Physical Properties Solubility Soluble in DMSO (25 mg/ml), warm ethanol (12.5 mg/ml), and DMF. Sensitivity Heat & Air sensitive Refractive Index n20D1.65 (Predicted) Boil Point(°C) 532.69° C at 760 mmHg (Predicted) Melt Point(°C) 182-185° C
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H317: May cause an allergic skin reaction
H400: Very toxic to aquatic life
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P391: Collect spillage.
WGK Germany 3 RIDADR UN30779/PGIII
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