Grouped product items

SKU

Size

Availability

Price

Qty

T287805-5mg

5mg

Available within 4-8 weeks(?)

$130.90

T287805-10mg

10mg

Available within 4-8 weeks(?)

$201.90

T287805-25mg

25mg

Available within 4-8 weeks(?)

$453.90

T287805-50mg

50mg

Available within 4-8 weeks(?)

$815.90

T287805-100mg

100mg

Available within 4-8 weeks(?)

$1,468.90

Basic Description

Synonyms	IP3K Inhibitor \| 519178-28-0 \| TNP \| N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine \| CHEMBL467591 \| 6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine \| IP3KInhibitor \| Kcs1 Inhibitor \| Inos
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50= 0.47μM for inhibition of InsP7formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50= 10.2μM). Binds to the ATP binding site of IP3K (Ki= 4.3μM).TNP is a potent and
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)

Discover Target: AKT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDK1 Tchem Cyclin-dependent kinase 1/cyclin B1 (1887 Activities)

Discover Target: CDK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IP6K1 Tbio Inositol hexakisphosphate kinase 1 (80 Activities)

Discover Target: IP6K1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IP6K3 Tbio Inositol hexakisphosphate kinase 3 (42 Activities)

Discover Target: IP6K3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Akt1 RAC-alpha serine/threonine-protein kinase (147 Activities)

Discover Target: Akt1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ip6k2 Inositol hexakisphosphate kinase 2 (3 Activities)

Discover Target: Ip6k2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine
INCHI	InChI=1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29)
InChi Key	DDSBPUYZPWNNGH-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC(=C1)C(F)(F)F)CNC2=NC3=C(C(=N2)NCC4=CC=C(C=C4)[N+](=O)[O-])NC=N3
Isomeric SMILES	C1=CC(=CC(=C1)C(F)(F)F)CNC2=NC3=C(C(=N2)NCC4=CC=C(C=C4)[N+](=O)[O-])NC=N3
WGK Germany	3
PubChem CID	16760513
Molecular Weight	443.38

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot Number	Certificate Type	Date	Item
H2315558	Certificate of Analysis	Jul 28, 2023	T287805
H2315559	Certificate of Analysis	Jul 28, 2023	T287805
H2315560	Certificate of Analysis	Jul 28, 2023	T287805
H2315561	Certificate of Analysis	Jul 28, 2023	T287805
H2315562	Certificate of Analysis	Jul 28, 2023	T287805

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 44.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 11.08, Max Conc. mM: 25
Sensitivity	light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H300:Fatal if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	3
RIDADR	UN28116.1/PGIII

Citations of This Product

1. Siyuan Zhang, Jiao He, Xinjian Cheng. (2023) Amphiphilic Hyperbranched Polymers for Selective and Sensitive Detection of 4-Nitrophenol. ACS Applied Polymer Materials, 5 (9): (7590–7601). [PMID:]
2. Hai Zhu, Tong-Mou Geng, Kai-Bin Tang. (2023) Fully Flexible Covalent Organic Frameworks for Fluorescence Sensing 2,4,6-Trinitrophenol and p-Nitrophenol. Polymers, 15 (3): (653). [PMID:36771953]
3. Die Wang, Luminita Marin, Xinjian Cheng. (2022) Chitosan-bodipy macromolecular fluorescent probes prepared by click reactions for highly sensitive and selective recognition of 2,4-dinitrophenylhydrazine. NEW JOURNAL OF CHEMISTRY, 46 (43): (20699-20710). [PMID:]
4. Hai-Bo Wang, Bei-Bei Tao, Ning-Ning Wu, Hong-Ding Zhang, Yan-Ming Liu. (2022) Glutathione-stabilized copper nanoclusters mediated-inner filter effect for sensitive and selective determination of p-nitrophenol and alkaline phosphatase activity. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 271 (120948). [PMID:35104744]
5. X. Jiao, H. Li, X. Cheng. (2021) Cellulose-based fluorescent macromolecular sensors and their ability in 2, 4, 6-trinitrophenol detection. Materials Today Chemistry, 22 (100615). [PMID:]
6. Xiang Deng,Xiaomei Huang,Di Wu. (2015-04-22) Förster resonance-energy-transfer detection of 2,4,6-trinitrophenol using copper nanoclusters.. Analytical and bioanalytical chemistry, 407 ((16)): (4607-4613). [PMID:25893800]
7. Shikong Lu,Meihua Xue,Aojia Tao,Yuhui Weng,Bixia Yao,Wen Weng,Xiuchun Lin. (2020-10-16) Facile Microwave-Assisted Synthesis of Functionalized Carbon Nitride Quantum Dots as Fluorescence Probe for Fast and Highly Selective Detection of 2,4,6-Trinitrophenol.. Journal of fluorescence, 31 ((1)): (1-9). [PMID:33057853]

References

1. Siyuan Zhang, Jiao He, Xinjian Cheng. (2023) Amphiphilic Hyperbranched Polymers for Selective and Sensitive Detection of 4-Nitrophenol. ACS Applied Polymer Materials, 5 (9): (7590–7601). [PMID:]
2. Hai Zhu, Tong-Mou Geng, Kai-Bin Tang. (2023) Fully Flexible Covalent Organic Frameworks for Fluorescence Sensing 2,4,6-Trinitrophenol and p-Nitrophenol. Polymers, 15 (3): (653). [PMID:36771953]
3. Die Wang, Luminita Marin, Xinjian Cheng. (2022) Chitosan-bodipy macromolecular fluorescent probes prepared by click reactions for highly sensitive and selective recognition of 2,4-dinitrophenylhydrazine. NEW JOURNAL OF CHEMISTRY, 46 (43): (20699-20710). [PMID:]
4. Hai-Bo Wang, Bei-Bei Tao, Ning-Ning Wu, Hong-Ding Zhang, Yan-Ming Liu. (2022) Glutathione-stabilized copper nanoclusters mediated-inner filter effect for sensitive and selective determination of p-nitrophenol and alkaline phosphatase activity. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 271 (120948). [PMID:35104744]
5. X. Jiao, H. Li, X. Cheng. (2021) Cellulose-based fluorescent macromolecular sensors and their ability in 2, 4, 6-trinitrophenol detection. Materials Today Chemistry, 22 (100615). [PMID:]
6. Xiang Deng,Xiaomei Huang,Di Wu. (2015-04-22) Förster resonance-energy-transfer detection of 2,4,6-trinitrophenol using copper nanoclusters.. Analytical and bioanalytical chemistry, 407 ((16)): (4607-4613). [PMID:25893800]
7. Shikong Lu,Meihua Xue,Aojia Tao,Yuhui Weng,Bixia Yao,Wen Weng,Xiuchun Lin. (2020-10-16) Facile Microwave-Assisted Synthesis of Functionalized Carbon Nitride Quantum Dots as Fluorescence Probe for Fast and Highly Selective Detection of 2,4,6-Trinitrophenol.. Journal of fluorescence, 31 ((1)): (1-9). [PMID:33057853]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

TNP - ≥97%(HPLC), high purity , CAS No.519178-28-0

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
T287805-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$130.90
T287805-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$201.90
T287805-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$453.90
T287805-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$815.90
T287805-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,468.90