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TNP - ≥97%(HPLC), high purity , CAS No.519178-28-0

23 Citations

≥97%(HPLC)

CAS#: 519178-28-0
Formula: C₂₀H₁₆F₃N₇O₂
Molecular Weight: 443.38
PubChem CID: 16760513

Item Number

T287805

Grouped product items
SKU	Size	Availability	Price
T287805-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$130.90
T287805-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$201.90
T287805-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$453.90
T287805-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$815.90
T287805-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,468.90

Inhibitor of IP6K; also inhibits IP3K

Basic Description

Synonyms	(1-Hydroxy-3-(methyl(pentyl)amino)propane-1,1-diyl)diphosphonic acid monosodium salt \| CCG-221372 \| AKOS024457890 \| N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine \| TNP \| DTXSID60587903 \| SCHEMBL14235423 \| AKOS0407
Specifications & Purity	≥97%(HPLC)
Biochemical and Physiological Mechanisms	Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50= 0.47μM for inhibition of InsP7formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50= 10.2μM). Binds to the ATP binding site of IP3K (Ki= 4.3μM).TNP is a potent and
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)

Discover Target: AKT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CDK1 Tchem Cyclin-dependent kinase 1/cyclin B1 (1887 Activities)

Discover Target: CDK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IP6K1 Tbio Inositol hexakisphosphate kinase 1 (80 Activities)

Discover Target: IP6K1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Akt1 RAC-alpha serine/threonine-protein kinase (147 Activities)

Discover Target: Akt1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ip6k2 Inositol hexakisphosphate kinase 2 (3 Activities)

Discover Target: Ip6k2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine
INCHI	InChI=1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29)
InChi Key	DDSBPUYZPWNNGH-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC(=C1)C(F)(F)F)CNC2=NC3=C(C(=N2)NCC4=CC=C(C=C4)[N+](=O)[O-])NC=N3
Isomeric SMILES	C1=CC(=CC(=C1)C(F)(F)F)CNC2=NC3=C(C(=N2)NCC4=CC=C(C=C4)[N+](=O)[O-])NC=N3
WGK Germany	3
PubChem CID	16760513
Molecular Weight	443.38

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
H2315558	Certificate of Analysis	Jul 28, 2023	T287805
H2315559	Certificate of Analysis	Jul 28, 2023	T287805
H2315560	Certificate of Analysis	Jul 28, 2023	T287805
H2315561	Certificate of Analysis	Jul 28, 2023	T287805
H2315562	Certificate of Analysis	Jul 28, 2023	T287805

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 44.34, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 11.08, Max Conc. mM: 25
Sensitivity	light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H300:Fatal if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	3
RIDADR	UN28116.1/PGIII

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Siyuan Zhang, Jiao He, Xinjian Cheng. (2023) Amphiphilic Hyperbranched Polymers for Selective and Sensitive Detection of 4-Nitrophenol. ACS Applied Polymer Materials, 5 (9): (7590–7601). [PMID:] [10.1021/acsapm.3c01515]
2. Hai Zhu, Tong-Mou Geng, Kai-Bin Tang. (2023) Fully Flexible Covalent Organic Frameworks for Fluorescence Sensing 2,4,6-Trinitrophenol and p-Nitrophenol. Polymers, 15 (3): (653). [PMID:36771953] [10.3390/polym15030653]
3. Die Wang, Luminita Marin, Xinjian Cheng. (2022) Chitosan-bodipy macromolecular fluorescent probes prepared by click reactions for highly sensitive and selective recognition of 2,4-dinitrophenylhydrazine. NEW JOURNAL OF CHEMISTRY, 46 (43): (20699-20710). [PMID:] [10.1039/D2NJ03923K]
4. Hai-Bo Wang, Bei-Bei Tao, Ning-Ning Wu, Hong-Ding Zhang, Yan-Ming Liu. (2022) Glutathione-stabilized copper nanoclusters mediated-inner filter effect for sensitive and selective determination of p-nitrophenol and alkaline phosphatase activity. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 271 (120948). [PMID:35104744] [10.1016/j.saa.2022.120948]
5. X. Jiao, H. Li, X. Cheng. (2021) Cellulose-based fluorescent macromolecular sensors and their ability in 2, 4, 6-trinitrophenol detection. Materials Today Chemistry, 22 (100615). [PMID:] [10.1016/j.mtchem.2021.100615]
6. Gao Ruru, Wang Junhong, Wang Han, Dong Wei, Zhu Junwu. (2021) Fluorescent nucleotide-lanthanide nanoparticles for highly selective determination of picric acid. MICROCHIMICA ACTA, 188 (1): (1-8). [PMID:33404778] [10.1007/s00604-020-04686-w]
7. Qian Liu, Feifei Zhao, Bingfeng Shi, Changli Lü. (2020) Mussel-inspired polydopamine-encapsulated carbon dots with dual emission for detection of 4-nitrophenol and Fe3+. LUMINESCENCE, 36 (2): (431-442). [PMID:33043598] [10.1002/bio.3961]
8. Yun Zhao, Min Pan, Feng Liu, Yahua Liu, Ping Dong, Jie Feng, Tianhui Shi, Xiaoqing Liu. (2020) Highly selective and sensitive detection of trinitrotoluene by framework-enhanced fluorescence of gold nanoclusters. ANALYTICA CHIMICA ACTA, 1106 (133). [PMID:32145841] [10.1016/j.aca.2020.01.055]
9. Feifei Zhao, Tianyi Zhang, Qian Liu, Changli Lü. (2020) Aphen-derived N-doped white-emitting carbon dots with room temperature phosphorescence for versatile applications. SENSORS AND ACTUATORS B-CHEMICAL, 304 (127344). [PMID:] [10.1016/j.snb.2019.127344]
10. Bijiang Geng, Hua Qin, Wenwen Shen, Ping Li, Fuling Fang, Xiaokai Li, Dengyu Pan, Longxiang Shen. (2020) Carbon dot/WS2 heterojunctions for NIR-II enhanced photothermal therapy of osteosarcoma and bone regeneration. CHEMICAL ENGINEERING JOURNAL, 383 (123102). [PMID:] [10.1016/j.cej.2019.123102]
11. YaoYao Qu, Guojuan Ren, Liying Yu, Baoya Zhu, Fang Chai, Lihua Chen. (2019) The carbon dots as colorimetric and fluorescent dual-readout probe for 2-nitrophenol and 4-nitrophenol detection. JOURNAL OF LUMINESCENCE, 207 (589). [PMID:] [10.1016/j.jlumin.2018.12.017]
12. Yulian Li, Lingyun Feng, Wei Yan, Irshad Hussain, Li Su, Bien Tan. (2019) PVP-templated highly luminescent copper nanoclusters for sensing trinitrophenol and living cell imaging. Nanoscale, 11 (3): (1286-1294). [PMID:30603761] [10.1039/C8NR07142J]
13. Huanhuan Fan, Guo Qiang Xiang, Yule Wang, Heng Zhang, Keke Ning, Junyue Duan, Lijun He, Xiuming Jiang, Wenjie Zhao. (2018) Manganese-doped carbon quantum dots-based fluorescent probe for selective and sensitive sensing of 2,4,6-trinitrophenol via an inner filtering effect. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 205 (221). [PMID:30015029] [10.1016/j.saa.2018.07.006]
14. Fangfang Li, Fengyi Wang, Xuan Hu, Baozhan Zheng, Juan Du, Dan Xiao. (2018) A long-persistent phosphorescent chemosensor for the detection of TNP based on CaTiO3:Pr3+@SiO2 photoluminescence materials. RSC Advances, 8 (30): (16603-16610). [PMID:35540505] [10.1039/C8RA02665C]
15. Yanlong Chen, Wenfen Zhang, Yanhao Zhang, Zhifen Deng, Wenjie Zhao, Huifang Du, Xue Ma, Dan Yin, Fuwei Xie, Yu Chen, Shusheng Zhang. (2018) In situ preparation of core–shell magnetic porous aromatic framework nanoparticles for mixed–mode solid–phase extraction of trace multitarget analytes. JOURNAL OF CHROMATOGRAPHY A, 1556 (1). [PMID:29735279] [10.1016/j.chroma.2018.04.039]
16. Kezheng Gao, Yaqing Guo, Qingyuan Niu, Lifeng Han, Liming Zhou, Lizhen Wang. (2018) Quaternary ammonium-functionalized carbon dots for sensitive and selective detection of 2,4,6-trinitrophenol in aqueous medium. SENSORS AND ACTUATORS B-CHEMICAL, 262 (298). [PMID:] [10.1016/j.snb.2018.02.008]
17. Fei Qu, Ping Chen, Shuyun Zhu, Jinmao You. (2017) High selectivity of colorimetric detection of p-nitrophenol based on Ag nanoclusters. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 171 (449). [PMID:27579789] [10.1016/j.saa.2016.08.043]
18. Meng Li Liu, Bin Bin Chen, Ze Xi Liu, Cheng Zhi Huang. (2016) Highly selective and sensitive detection of 2,4,6-trinitrophenol by using newly developed blue–green photoluminescent carbon nanodots. TALANTA, 161 (875). [PMID:27769497] [10.1016/j.talanta.2016.08.046]
19. Bin Bin Chen, Ze Xi Liu, Hong Yan Zou, Cheng Zhi Huang. (2016) Highly selective detection of 2,4,6-trinitrophenol by using newly developed terbium-doped blue carbon dots. ANALYST, 141 (9): (2676-2681). [PMID:27109163] [10.1039/C5AN02569A]
20. Zheng-Yong Chen, Hong-Wen Gao, Jia-Xiang Yang. (2014) PEI@Mg2SiO4: an efficient carbon dioxide and nitrophenol compounds adsorbing material. RSC Advances, 4 (64): (33866-33873). [PMID:] [10.1039/C4RA04928D]
21. Xin Yang, Junhai Wang, Dongyue Su, Qingdong Xia, Fang Chai, Chungang Wang, Fengyu Qu. (2014) Fluorescent detection of TNT and 4-nitrophenol by BSA Au nanoclusters. DALTON TRANSACTIONS, 43 (26): (10057-10063). [PMID:24871909] [10.1039/C4DT00490F]
22. Xiang Deng,Xiaomei Huang,Di Wu. (2015-04-22) Förster resonance-energy-transfer detection of 2,4,6-trinitrophenol using copper nanoclusters.. Analytical and bioanalytical chemistry, 407 ((16)): (4607-4613). [PMID:25893800]
23. Shikong Lu,Meihua Xue,Aojia Tao,Yuhui Weng,Bixia Yao,Wen Weng,Xiuchun Lin. (2020-10-16) Facile Microwave-Assisted Synthesis of Functionalized Carbon Nitride Quantum Dots as Fluorescence Probe for Fast and Highly Selective Detection of 2,4,6-Trinitrophenol.. Journal of fluorescence, 31 ((1)): (1-9). [PMID:33057853]

References

1. Siyuan Zhang, Jiao He, Xinjian Cheng. (2023) Amphiphilic Hyperbranched Polymers for Selective and Sensitive Detection of 4-Nitrophenol. ACS Applied Polymer Materials, 5 (9): (7590–7601). [PMID:] [10.1021/acsapm.3c01515]
2. Hai Zhu, Tong-Mou Geng, Kai-Bin Tang. (2023) Fully Flexible Covalent Organic Frameworks for Fluorescence Sensing 2,4,6-Trinitrophenol and p-Nitrophenol. Polymers, 15 (3): (653). [PMID:36771953] [10.3390/polym15030653]
3. Die Wang, Luminita Marin, Xinjian Cheng. (2022) Chitosan-bodipy macromolecular fluorescent probes prepared by click reactions for highly sensitive and selective recognition of 2,4-dinitrophenylhydrazine. NEW JOURNAL OF CHEMISTRY, 46 (43): (20699-20710). [PMID:] [10.1039/D2NJ03923K]
4. Hai-Bo Wang, Bei-Bei Tao, Ning-Ning Wu, Hong-Ding Zhang, Yan-Ming Liu. (2022) Glutathione-stabilized copper nanoclusters mediated-inner filter effect for sensitive and selective determination of p-nitrophenol and alkaline phosphatase activity. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 271 (120948). [PMID:35104744] [10.1016/j.saa.2022.120948]
5. X. Jiao, H. Li, X. Cheng. (2021) Cellulose-based fluorescent macromolecular sensors and their ability in 2, 4, 6-trinitrophenol detection. Materials Today Chemistry, 22 (100615). [PMID:] [10.1016/j.mtchem.2021.100615]
6. Gao Ruru, Wang Junhong, Wang Han, Dong Wei, Zhu Junwu. (2021) Fluorescent nucleotide-lanthanide nanoparticles for highly selective determination of picric acid. MICROCHIMICA ACTA, 188 (1): (1-8). [PMID:33404778] [10.1007/s00604-020-04686-w]
7. Qian Liu, Feifei Zhao, Bingfeng Shi, Changli Lü. (2020) Mussel-inspired polydopamine-encapsulated carbon dots with dual emission for detection of 4-nitrophenol and Fe3+. LUMINESCENCE, 36 (2): (431-442). [PMID:33043598] [10.1002/bio.3961]
8. Yun Zhao, Min Pan, Feng Liu, Yahua Liu, Ping Dong, Jie Feng, Tianhui Shi, Xiaoqing Liu. (2020) Highly selective and sensitive detection of trinitrotoluene by framework-enhanced fluorescence of gold nanoclusters. ANALYTICA CHIMICA ACTA, 1106 (133). [PMID:32145841] [10.1016/j.aca.2020.01.055]
9. Feifei Zhao, Tianyi Zhang, Qian Liu, Changli Lü. (2020) Aphen-derived N-doped white-emitting carbon dots with room temperature phosphorescence for versatile applications. SENSORS AND ACTUATORS B-CHEMICAL, 304 (127344). [PMID:] [10.1016/j.snb.2019.127344]
10. Bijiang Geng, Hua Qin, Wenwen Shen, Ping Li, Fuling Fang, Xiaokai Li, Dengyu Pan, Longxiang Shen. (2020) Carbon dot/WS2 heterojunctions for NIR-II enhanced photothermal therapy of osteosarcoma and bone regeneration. CHEMICAL ENGINEERING JOURNAL, 383 (123102). [PMID:] [10.1016/j.cej.2019.123102]
11. YaoYao Qu, Guojuan Ren, Liying Yu, Baoya Zhu, Fang Chai, Lihua Chen. (2019) The carbon dots as colorimetric and fluorescent dual-readout probe for 2-nitrophenol and 4-nitrophenol detection. JOURNAL OF LUMINESCENCE, 207 (589). [PMID:] [10.1016/j.jlumin.2018.12.017]
12. Yulian Li, Lingyun Feng, Wei Yan, Irshad Hussain, Li Su, Bien Tan. (2019) PVP-templated highly luminescent copper nanoclusters for sensing trinitrophenol and living cell imaging. Nanoscale, 11 (3): (1286-1294). [PMID:30603761] [10.1039/C8NR07142J]
13. Huanhuan Fan, Guo Qiang Xiang, Yule Wang, Heng Zhang, Keke Ning, Junyue Duan, Lijun He, Xiuming Jiang, Wenjie Zhao. (2018) Manganese-doped carbon quantum dots-based fluorescent probe for selective and sensitive sensing of 2,4,6-trinitrophenol via an inner filtering effect. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 205 (221). [PMID:30015029] [10.1016/j.saa.2018.07.006]
14. Fangfang Li, Fengyi Wang, Xuan Hu, Baozhan Zheng, Juan Du, Dan Xiao. (2018) A long-persistent phosphorescent chemosensor for the detection of TNP based on CaTiO3:Pr3+@SiO2 photoluminescence materials. RSC Advances, 8 (30): (16603-16610). [PMID:35540505] [10.1039/C8RA02665C]
15. Yanlong Chen, Wenfen Zhang, Yanhao Zhang, Zhifen Deng, Wenjie Zhao, Huifang Du, Xue Ma, Dan Yin, Fuwei Xie, Yu Chen, Shusheng Zhang. (2018) In situ preparation of core–shell magnetic porous aromatic framework nanoparticles for mixed–mode solid–phase extraction of trace multitarget analytes. JOURNAL OF CHROMATOGRAPHY A, 1556 (1). [PMID:29735279] [10.1016/j.chroma.2018.04.039]
16. Kezheng Gao, Yaqing Guo, Qingyuan Niu, Lifeng Han, Liming Zhou, Lizhen Wang. (2018) Quaternary ammonium-functionalized carbon dots for sensitive and selective detection of 2,4,6-trinitrophenol in aqueous medium. SENSORS AND ACTUATORS B-CHEMICAL, 262 (298). [PMID:] [10.1016/j.snb.2018.02.008]
17. Fei Qu, Ping Chen, Shuyun Zhu, Jinmao You. (2017) High selectivity of colorimetric detection of p-nitrophenol based on Ag nanoclusters. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 171 (449). [PMID:27579789] [10.1016/j.saa.2016.08.043]
18. Meng Li Liu, Bin Bin Chen, Ze Xi Liu, Cheng Zhi Huang. (2016) Highly selective and sensitive detection of 2,4,6-trinitrophenol by using newly developed blue–green photoluminescent carbon nanodots. TALANTA, 161 (875). [PMID:27769497] [10.1016/j.talanta.2016.08.046]
19. Bin Bin Chen, Ze Xi Liu, Hong Yan Zou, Cheng Zhi Huang. (2016) Highly selective detection of 2,4,6-trinitrophenol by using newly developed terbium-doped blue carbon dots. ANALYST, 141 (9): (2676-2681). [PMID:27109163] [10.1039/C5AN02569A]
20. Zheng-Yong Chen, Hong-Wen Gao, Jia-Xiang Yang. (2014) PEI@Mg2SiO4: an efficient carbon dioxide and nitrophenol compounds adsorbing material. RSC Advances, 4 (64): (33866-33873). [PMID:] [10.1039/C4RA04928D]
21. Xin Yang, Junhai Wang, Dongyue Su, Qingdong Xia, Fang Chai, Chungang Wang, Fengyu Qu. (2014) Fluorescent detection of TNT and 4-nitrophenol by BSA Au nanoclusters. DALTON TRANSACTIONS, 43 (26): (10057-10063). [PMID:24871909] [10.1039/C4DT00490F]
22. Xiang Deng,Xiaomei Huang,Di Wu. (2015-04-22) Förster resonance-energy-transfer detection of 2,4,6-trinitrophenol using copper nanoclusters.. Analytical and bioanalytical chemistry, 407 ((16)): (4607-4613). [PMID:25893800]
23. Shikong Lu,Meihua Xue,Aojia Tao,Yuhui Weng,Bixia Yao,Wen Weng,Xiuchun Lin. (2020-10-16) Facile Microwave-Assisted Synthesis of Functionalized Carbon Nitride Quantum Dots as Fluorescence Probe for Fast and Highly Selective Detection of 2,4,6-Trinitrophenol.. Journal of fluorescence, 31 ((1)): (1-9). [PMID:33057853]

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