Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T100847-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $9.90 | |
T100847-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $26.90 | |
T100847-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $100.90 | |
T100847-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $407.90 | |
T100847-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,467.90 |
Ribosomal translation inhibitor
Synonyms | TOBRADEX ST COMPONENT TOBRAMYCIN | TOBRAMYCIN (MART.) | TOBRAMYCIN [WHO-DD] | Tobramicina | Tobramycin,(S) | AT02 - Tobramycin | Spectrum_001072 | Nebicin | (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl |
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Specifications & Purity | Moligand™, ≥98%, Potency ≥900uG/mg |
Biochemical and Physiological Mechanisms | Primary Target myeloperoxidase-dependent oxidant cell injury.Inhibits ribosomal translation. Aminoglycoside antibiotic which binds 30S ribosomal subunit A, preventing functional protein production. Effective against gram-negative bacteria. |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of TAS2R20 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Tobramycin is an aminoglycoside antibiotic with similar structure to the kanamycins and gentamycins. It is useful for respiratory infection and cystic fibrosis research. |
ALogP | -6.2 |
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IUPAC Name | (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol |
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INCHI | InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1 |
InChi Key | NLVFBUXFDBBNBW-PBSUHMDJSA-N |
Canonical SMILES | C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N |
Isomeric SMILES | C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N |
WGK Germany | 2 |
RTECS | WK2100000 |
PubChem CID | 36294 |
Molecular Weight | 467.51 |
Beilstein | 1357507 |
Reaxy-Rn | 1357507 |
RCSB PDB Ligand | TOY |
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PubChem CID | 36294 |
CAS Registry No. | 32986-56-4 |
ChEMBL Ligand | CHEMBL1747 |
DrugBank Ligand | DB00684 |
DrugCentral Ligand | 2684 |
Antibiotic DB | 1844 |
Enter Lot Number to search for COA:
Solubility | Soluble in water (94 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), methanol, and PBS (pH 7.2) (~10 mg/ml)., |
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Sensitivity | Moisture sensitive |
Refractive Index | 143 |
Specific Rotation[α] | 143 ° (C=4, H2O) |
Melt Point(°C) | 178°C |
WGK Germany | 2 |
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RTECS | WK2100000 |
Reaxy-Rn | 1357507 |
Merck Index | 9490 |
1. Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan. (2024) A highly stretchable, adhesive, and antibacterial hydrogel with chitosan and tobramycin as dynamic cross-linkers for treating the infected diabetic wound. CARBOHYDRATE POLYMERS, 324 (121543). [PMID:37985115] |
2. Peng Li, Baihui Wang, Mengyao Qi, Huan Jiang, Yifei Li, Xia Zhang. (2023) Construction of aptamer sensor based on Au nanozymes for ultrasensitive SERS detection of tobramycin. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 123 (105617). [PMID:] |
3. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan. (2023) Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection. Biosensors-Basel, 13 (4): (489). [PMID:37185564] |
4. Jing Han, Pengfei Ma, Imran Mahmood Khan, Yin Zhang, Zhouping Wang. (2023) Study of binding mechanism of aptamer to kanamycin and the development of fluorescent aptasensor in milk detection. TALANTA, 260 (124530). [PMID:37116356] |
5. Yuanyuan Zhang, Yuan Zhu, Tianjing Zeng, Lu Qiao, Mingjuan Zhang, Kexin Song, Nian Yin, Yani Tao, Yue Zhao, Chang Zhang, Yi Zhang. (2023) Self-powered photoelectrochemical aptasensor based on hollow tubular g-C3N4/Bi/BiVO4 for tobramycin detection. ANALYTICA CHIMICA ACTA, 1250 (340951). [PMID:36898823] |
6. Xiaojie Wei, Chengbin Liu, Hehe Qin, Ziwei Ye, Xinru Liu, Boyang Zong, Zhuo Li, Shun Mao. (2023) Fast, specific, and ultrasensitive antibiotic residue detection by monolayer WS2-based field-effect transistor sensor. JOURNAL OF HAZARDOUS MATERIALS, 443 (130299). [PMID:36356526] |
7. Chi Zhang, Gaiping Li, Baoxian Ye, Lina Zou, Weihang Wang, Yanli Ji. (2022) A reproducible electrochemical biosensor for tobramycin highly sensitive detection based on ExoIII-assisted nucleic acid circulation and CHA reaction. MICROCHEMICAL JOURNAL, 183 (108040). [PMID:] |
8. Wenjuan Liu, Minglong Yan, Wenjie Zhao. (2023) Antibacterial-renew dual-function anti-biofouling strategy: Self-assembled Schiff-base metal complex coatings built from natural products. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 629 (496). [PMID:36088695] |
9. He Ziguo, Liu Jiaxu, Zhang Cheng, Sun Yudie, Chen Qian, Zhang Jian, Liu Shengjun, Yue Caibo, Ye Mingfu, Zhang Kui. (2023) Spectrally tunable humic acid–based carbon dots: a simple platform for metronidazole and ornidazole sensing in multiple real samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (18): (4221-4232). [PMID:36002744] |
10. Lina Wang, Xiangbiao Zeng, Li Zhang, Ying Yu, Bixia Lin, Yumin Wang, Manli Guo, Yujuan Cao. (2022) Field-free electrochemical sensor: A novel inverted Y-type DNA conformation possessing specific self-transform capability for ultrasensitive determination of tetracycline. MICROCHEMICAL JOURNAL, 181 (107724). [PMID:] |
11. Xiaofei Liao, Mengyan Li, Li Zou. (2022) Target-induced activation of DNAzyme for highly sensitive colorimetric detection of bleomycin via DNA scission. RSC Advances, 12 (29): (18296-18300). [PMID:35799941] |
12. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] |
13. Jingjing Li, Long Jiang, Xu Wang, Zhixue Zhu, Qingxin Zhang, Su Liu, Yu Wang, Jiadong Huang. (2022) Ultrasensitive electrochemical aptasensor based on palindromic sequence mediated bidirectional SDA and a DNAzyme walker for kanamycin detection. NEW JOURNAL OF CHEMISTRY, 46 (21): (10394-10401). [PMID:] |
14. Xiuxiu Yang, Zhongqiang Yang. (2022) Simple and Rapid Detection of Ibuprofen─A Typical Pharmaceuticals and Personal Care Products─by a Liquid Crystal Aptasensor. LANGMUIR, 38 (1): (282–288). [PMID:34955019] |
15. Kecheng Quan, Zexin Zhang, Yijin Ren, Henk J. Busscher, Henny C. van der Mei, Brandon W. Peterson. (2021) On-demand pulling-off of magnetic nanoparticles from biomaterial surfaces through implant-associated infectious biofilms for enhanced antibiotic efficacy. Materials Science & Engineering C-Materials for Biological Applications, 131 (112526). [PMID:34857305] |
16. Jinmei Li, Dong Wang, Yang Wang, Baoyu Gao, Zhining Wang. (2021) Surface Modification of Reverse Osmosis Membranes for Enhanced Boron Removal and Fouling Resistance. ACS ES&T Water, 1 (10): (2284–2292). [PMID:] |
1. Haas W, Pillar CM, Zurenko GE, Lee JC, Brunner LS, Morris TW. (2009) Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria.. Antimicrob Agents Chemother, 53 (8): (3552-60). [PMID:19506065] |
2. Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ. (2011) New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view.. Kidney Int, 79 (1): (33-45). [PMID:20861826] |
3. Wargo KA, Edwards JD. (2014) Aminoglycoside-induced nephrotoxicity.. J Pharm Pract, 27 (6): (573-7). [PMID:25199523] |
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5. Beznosková P et al.. (2019) Yeast applied readthrough inducing system (YARIS): an invivo assay for the comprehensive study of translational readthrough.. Nucleic Acids Res, 47 (12): (6339-6350). [PMID:31069379] |
6. Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan. (2024) A highly stretchable, adhesive, and antibacterial hydrogel with chitosan and tobramycin as dynamic cross-linkers for treating the infected diabetic wound. CARBOHYDRATE POLYMERS, 324 (121543). [PMID:37985115] |
7. Peng Li, Baihui Wang, Mengyao Qi, Huan Jiang, Yifei Li, Xia Zhang. (2023) Construction of aptamer sensor based on Au nanozymes for ultrasensitive SERS detection of tobramycin. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 123 (105617). [PMID:] |
8. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan. (2023) Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection. Biosensors-Basel, 13 (4): (489). [PMID:37185564] |
9. Jing Han, Pengfei Ma, Imran Mahmood Khan, Yin Zhang, Zhouping Wang. (2023) Study of binding mechanism of aptamer to kanamycin and the development of fluorescent aptasensor in milk detection. TALANTA, 260 (124530). [PMID:37116356] |
10. Yuanyuan Zhang, Yuan Zhu, Tianjing Zeng, Lu Qiao, Mingjuan Zhang, Kexin Song, Nian Yin, Yani Tao, Yue Zhao, Chang Zhang, Yi Zhang. (2023) Self-powered photoelectrochemical aptasensor based on hollow tubular g-C3N4/Bi/BiVO4 for tobramycin detection. ANALYTICA CHIMICA ACTA, 1250 (340951). [PMID:36898823] |
11. Xiaojie Wei, Chengbin Liu, Hehe Qin, Ziwei Ye, Xinru Liu, Boyang Zong, Zhuo Li, Shun Mao. (2023) Fast, specific, and ultrasensitive antibiotic residue detection by monolayer WS2-based field-effect transistor sensor. JOURNAL OF HAZARDOUS MATERIALS, 443 (130299). [PMID:36356526] |
12. Chi Zhang, Gaiping Li, Baoxian Ye, Lina Zou, Weihang Wang, Yanli Ji. (2022) A reproducible electrochemical biosensor for tobramycin highly sensitive detection based on ExoIII-assisted nucleic acid circulation and CHA reaction. MICROCHEMICAL JOURNAL, 183 (108040). [PMID:] |
13. Wenjuan Liu, Minglong Yan, Wenjie Zhao. (2023) Antibacterial-renew dual-function anti-biofouling strategy: Self-assembled Schiff-base metal complex coatings built from natural products. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 629 (496). [PMID:36088695] |
14. He Ziguo, Liu Jiaxu, Zhang Cheng, Sun Yudie, Chen Qian, Zhang Jian, Liu Shengjun, Yue Caibo, Ye Mingfu, Zhang Kui. (2023) Spectrally tunable humic acid–based carbon dots: a simple platform for metronidazole and ornidazole sensing in multiple real samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 415 (18): (4221-4232). [PMID:36002744] |
15. Lina Wang, Xiangbiao Zeng, Li Zhang, Ying Yu, Bixia Lin, Yumin Wang, Manli Guo, Yujuan Cao. (2022) Field-free electrochemical sensor: A novel inverted Y-type DNA conformation possessing specific self-transform capability for ultrasensitive determination of tetracycline. MICROCHEMICAL JOURNAL, 181 (107724). [PMID:] |
16. Xiaofei Liao, Mengyan Li, Li Zou. (2022) Target-induced activation of DNAzyme for highly sensitive colorimetric detection of bleomycin via DNA scission. RSC Advances, 12 (29): (18296-18300). [PMID:35799941] |
17. Lishan Zhang, Zujie Yao, Huamei Tang, Qingli Song, Huanhuan Song, Jindong Yao, Zhen Li, Xiaofang Xie, Yuexu Lin, Xiangmin Lin. (2022) The Lysine Acetylation Modification in the Porin Aha1 of Aeromonas hydrophila Regulates the Uptake of Multidrug Antibiotics. MOLECULAR & CELLULAR PROTEOMICS, 21 (9): [PMID:35605723] |
18. Jingjing Li, Long Jiang, Xu Wang, Zhixue Zhu, Qingxin Zhang, Su Liu, Yu Wang, Jiadong Huang. (2022) Ultrasensitive electrochemical aptasensor based on palindromic sequence mediated bidirectional SDA and a DNAzyme walker for kanamycin detection. NEW JOURNAL OF CHEMISTRY, 46 (21): (10394-10401). [PMID:] |
19. Xiuxiu Yang, Zhongqiang Yang. (2022) Simple and Rapid Detection of Ibuprofen─A Typical Pharmaceuticals and Personal Care Products─by a Liquid Crystal Aptasensor. LANGMUIR, 38 (1): (282–288). [PMID:34955019] |
20. Kecheng Quan, Zexin Zhang, Yijin Ren, Henk J. Busscher, Henny C. van der Mei, Brandon W. Peterson. (2021) On-demand pulling-off of magnetic nanoparticles from biomaterial surfaces through implant-associated infectious biofilms for enhanced antibiotic efficacy. Materials Science & Engineering C-Materials for Biological Applications, 131 (112526). [PMID:34857305] |
21. Jinmei Li, Dong Wang, Yang Wang, Baoyu Gao, Zhining Wang. (2021) Surface Modification of Reverse Osmosis Membranes for Enhanced Boron Removal and Fouling Resistance. ACS ES&T Water, 1 (10): (2284–2292). [PMID:] |