Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T100847-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $9.90 | |
T100847-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $26.90 | |
T100847-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $100.90 | |
T100847-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $407.90 | |
T100847-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,467.90 |
Ribosomal translation inhibitor
Synonyms | TOBRADEX ST COMPONENT TOBRAMYCIN | TOBRAMYCIN (MART.) | TOBRAMYCIN [WHO-DD] | Tobramicina | Tobramycin,(S) | AT02 - Tobramycin | Spectrum_001072 | Nebicin | (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl |
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Specifications & Purity | Moligand™, ≥98%, Potency ≥900uG/mg |
Biochemical and Physiological Mechanisms | Primary Target myeloperoxidase-dependent oxidant cell injury.Inhibits ribosomal translation. Aminoglycoside antibiotic which binds 30S ribosomal subunit A, preventing functional protein production. Effective against gram-negative bacteria. |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of TAS2R20 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Tobramycin is an aminoglycoside antibiotic with similar structure to the kanamycins and gentamycins. It is useful for respiratory infection and cystic fibrosis research. |
ALogP | -6.2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol |
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INCHI | InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1 |
InChi Key | NLVFBUXFDBBNBW-PBSUHMDJSA-N |
Canonical SMILES | C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N |
Isomeric SMILES | C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N |
WGK Germany | 2 |
RTECS | WK2100000 |
PubChem CID | 36294 |
Molecular Weight | 467.51 |
Beilstein | 1357507 |
Reaxy-Rn | 1357507 |
RCSB PDB Ligand | TOY |
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PubChem CID | 36294 |
CAS Registry No. | 32986-56-4 |
ChEMBL Ligand | CHEMBL1747 |
DrugBank Ligand | DB00684 |
DrugCentral Ligand | 2684 |
Antibiotic DB | 1844 |
Enter Lot Number to search for COA:
Solubility | Soluble in water (94 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), methanol, and PBS (pH 7.2) (~10 mg/ml)., |
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Sensitivity | Moisture sensitive |
Refractive Index | 143 |
Specific Rotation[α] | 143 ° (C=4, H2O) |
Melt Point(°C) | 178°C |
WGK Germany | 2 |
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RTECS | WK2100000 |
Reaxy-Rn | 1357507 |
Merck Index | 9490 |
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3. Jiawen Han, Yaru Ding, Xujuan Lv, Yuwei Zhang, Daoqing Fan. (2023) Integration of G-Quadruplex and Pyrene as a Simple and Efficient Ratiometric Fluorescent Platform That Programmed by Contrary Logic Pair for Highly Sensitive and Selective Coralyne (COR) Detection. Biosensors-Basel, 13 (4): (489). [PMID:37185564] [10.3390/bios13040489] |
4. Jing Han, Pengfei Ma, Imran Mahmood Khan, Yin Zhang, Zhouping Wang. (2023) Study of binding mechanism of aptamer to kanamycin and the development of fluorescent aptasensor in milk detection. TALANTA, 260 (124530). [PMID:37116356] [10.1016/j.talanta.2023.124530] |
5. Yuanyuan Zhang, Yuan Zhu, Tianjing Zeng, Lu Qiao, Mingjuan Zhang, Kexin Song, Nian Yin, Yani Tao, Yue Zhao, Chang Zhang, Yi Zhang. (2023) Self-powered photoelectrochemical aptasensor based on hollow tubular g-C3N4/Bi/BiVO4 for tobramycin detection. ANALYTICA CHIMICA ACTA, 1250 (340951). [PMID:36898823] [10.1016/j.aca.2023.340951] |
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13. Jingjing Li, Long Jiang, Xu Wang, Zhixue Zhu, Qingxin Zhang, Su Liu, Yu Wang, Jiadong Huang. (2022) Ultrasensitive electrochemical aptasensor based on palindromic sequence mediated bidirectional SDA and a DNAzyme walker for kanamycin detection. NEW JOURNAL OF CHEMISTRY, 46 (21): (10394-10401). [PMID:] [10.1039/D2NJ01368A] |
14. Xiuxiu Yang, Zhongqiang Yang. (2022) Simple and Rapid Detection of Ibuprofen─A Typical Pharmaceuticals and Personal Care Products─by a Liquid Crystal Aptasensor. LANGMUIR, 38 (1): (282–288). [PMID:34955019] [10.1021/acs.langmuir.1c02480] |
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19. Mengyao Zhang, Gang Chen, Mengheng Lei, Jiaqing Lei, Dan Li, Hua Zheng. (2021) A pH-sensitive oxidized-dextran based double drug-loaded hydrogel with high antibacterial properties. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 182 (385). [PMID:33798586] [10.1016/j.ijbiomac.2021.03.169] |
20. Qian Wang, Li Zhu, Yi Yu, Huashi Guan, Zhe Xu. (2021) Microbial Screening of Marine Natural Product Inhibitors for the 6′-Aminoglycoside Acetyltransferase 2″-Aminoglycoside Phosphotransferase [AAC(6′)-APH(2″)] Bifunctional Enzyme by Ultra-High Performance Liquid Chromatography–Mass Spectrometry (UHPLC-MS). ANALYTICAL LETTERS, 54 (18): (2895-2907). [PMID:] [10.1080/00032719.2021.1903025] |
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24. Yunlei Zhou, Yue Wang, Shurong Li, Xi Fang, Huanshun Yin, Po Wang, Shiyun Ai. (2020) A novel photoelectrochemical immunosensor for N1-methyladenine detection based on BiVO4/g-C3N4 heterojunction with signal amplification of TiO2@NH2-MIL-125(Ti). SENSORS AND ACTUATORS B-CHEMICAL, 318 (128310). [PMID:] [10.1016/j.snb.2020.128310] |
25. Yan Chen, Huanshun Yin, Fei Li, Jie Zhou, Lingsong Wang, Jun Wang, Shiyun Ai. (2020) Polydopamine-sensitized WS2/black-TiO2 heterojunction for histone acetyltransferase detection with enhanced visible-light-driven photoelectrochemical activity. CHEMICAL ENGINEERING JOURNAL, 393 (124707). [PMID:] [10.1016/j.cej.2020.124707] |
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27. Xiaoyan Chen, Sibei Hao, Boyang Zong, Chengbin Liu, Shun Mao. (2019) Ultraselective antibiotic sensing with complementary strand DNA assisted aptamer/MoS2 field-effect transistors. BIOSENSORS & BIOELECTRONICS, 145 (111711). [PMID:31563801] [10.1016/j.bios.2019.111711] |
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