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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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E129454-10mg | 10mg | In stock | $186.90 | |
E129454-50mg | 50mg | In stock | $783.90 | |
E129454-250mg | 250mg | In stock | $3,526.90 | |
E129454-1g | 1g | In stock | $12,696.90 | |
E129454-5g | 5g | In stock | $57,135.90 |
Cell-permeable JAK1/2/3 inhibitor
Synonyms | D09783 | Xeljanz | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate | CP-690550 Citrate (Tofacitinib Citrate) | UNII-O1FF4DIV0D | 3-((3R,4R)-4-Methyl-3-(methyl(7H |
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Specifications & Purity | ≥99% |
Biochemical and Physiological Mechanisms | Tofacitinib is a potent inhibitor of JAK3 (Janus kinase 3) with some JAK1 inhibitory activity as well. JAK3 blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory ac |
Legal Information | Sold for only research purposes |
Shipped In | Normal |
Action Type | INHIBITOR |
Mechanism of action | Janus Kinase (JAK) inhibitor |
Note | Toxic, refer to SDS for further information . Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Tofacitinib (CP-690550) Citrate is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488196565 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488196565 |
IUPAC Name | 2-hydroxypropane-1,2,3-tricarboxylic acid;3-[(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile |
INCHI | InChI=1S/C16H20N6O.C6H8O7/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11-,13+;/m1./s1 |
InChi Key | SYIKUFDOYJFGBQ-YLAFAASESA-N |
Canonical SMILES | CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |
Isomeric SMILES | C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |
WGK Germany | 3 |
PubChem CID | 10174505 |
Molecular Weight | 504.49 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
11 results found
Lot Number | Certificate Type | Date | Item |
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B2215632 | Certificate of Analysis | Dec 12, 2023 | E129454 |
B2215644 | Certificate of Analysis | Dec 12, 2023 | E129454 |
B2215653 | Certificate of Analysis | Dec 12, 2023 | E129454 |
B2215659 | Certificate of Analysis | Dec 12, 2023 | E129454 |
L2124045 | Certificate of Analysis | Oct 20, 2023 | E129454 |
G1520063 | Certificate of Analysis | Feb 03, 2023 | E129454 |
D1901054 | Certificate of Analysis | Nov 11, 2022 | E129454 |
B2212163 | Certificate of Analysis | Jan 10, 2022 | E129454 |
B2212165 | Certificate of Analysis | Jan 10, 2022 | E129454 |
G2308093 | Certificate of Analysis | Jan 10, 2022 | E129454 |
Solubility | Soluble in DMSO (100 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMF (~5 mg/ml), water (<1 mg/ml at 25 °C), and 0.5% methylcellulose (30 mg/ml at 25 °C). |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H302:Harmful if swallowed H360:May damage fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. |
WGK Germany | 3 |