Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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T131712-250mg | 250mg | In stock | $92.90 | |
T131712-1g | 1g | In stock | $230.90 | |
T131712-5g | 5g | In stock | $760.90 |
Synonyms | 1-(azepan-1-yl)-3-(4-methylbenzenesulfonyl)urea | 1-(4-Methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea | CBiol_001918 | TOLAZAMIDE [MART.] | KBioSS_000225 | Oprea1_061180 | Prestwick1_000554 | TOLAZAMIDE [USP MONOGRAPH] | AI3-50826 | KBio2_002793 | |
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Specifications & Purity | Moligand™, ≥96%(T) |
Biochemical and Physiological Mechanisms | Stimulates pancreatic islet cells to secrete insulin; blocks ATP-sensitive K+ channels. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | BLOCKER |
Mechanism of action | Sulfonylurea receptor 1, Kir6.2 blocker |
Product Description | Tolazamide can fall blood sugar |
ALogP | 1.5 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488179906 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179906 |
IUPAC Name | 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea |
INCHI | InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18) |
InChi Key | OUDSBRTVNLOZBN-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CCCCCC2 |
Isomeric SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CCCCCC2 |
PubChem CID | 5503 |
Molecular Weight | 311.4 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
F2223430 | Certificate of Analysis | Apr 03, 2024 | T131712 |
F2223436 | Certificate of Analysis | Apr 03, 2024 | T131712 |
L1910102 | Certificate of Analysis | Jul 07, 2023 | T131712 |
E23101003 | Certificate of Analysis | Dec 12, 2022 | T131712 |
E2310966 | Certificate of Analysis | Dec 12, 2022 | T131712 |
E2310976 | Certificate of Analysis | Dec 12, 2022 | T131712 |
E2310977 | Certificate of Analysis | Dec 12, 2022 | T131712 |
E2310980 | Certificate of Analysis | Dec 12, 2022 | T131712 |
E2310981 | Certificate of Analysis | Dec 12, 2022 | T131712 |
J1808119 | Certificate of Analysis | Jun 17, 2022 | T131712 |
Pictogram(s) | GHS08 |
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Signal | Danger |
Hazard Statements | H370:Causes damage to organs |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P308+P316:IF exposed or concerned: Get emergency medical help immediately. |
1. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li. (2023) An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods. Foods, 12 (3): (539). [PMID:36766067] [10.3390/foods12030539] |
2. Haihuan Xie, Yingying Li, Jin Wang, Yi Lei, Anastasios Koidis, Xiangmei Li, Xing Shen, Zhenlin Xu, Hongtao Lei. (2022) Broad-specific immunochromatography for simultaneous detection of various sulfonylureas in adulterated multi-herbal tea. FOOD CHEMISTRY, 370 (131055). [PMID:34536782] [10.1016/j.foodchem.2021.131055] |
1. Miki T, Nagashima K, Seino S. (1999) The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.. J Mol Endocrinol, 22 (2): (113-23). [PMID:10194514] [10.1021/op500134e] |
2. Rehmann H. (2012) Epac2: a sulfonylurea receptor?. Biochem Soc Trans, 40 (1): (6-10). [PMID:22260657] [10.1021/op500134e] |
3. Inagaki N, Gonoi T, Clement 4th JP, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, Bryan J. (1995) Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.. Science, 270 (5239): (1166-70). [PMID:7502040] [10.1021/op500134e] |
4. Zixian He, Zhiwei Liu, Haihuan Xie, Pengjie Luo, Xiangmei Li. (2023) An Ultrasensitive Lateral Flow Immunoassay Based on Metal-Organic Framework-Decorated Polydopamine for Multiple Sulfonylureas Adulteration in Functional Foods. Foods, 12 (3): (539). [PMID:36766067] [10.3390/foods12030539] |
5. Haihuan Xie, Yingying Li, Jin Wang, Yi Lei, Anastasios Koidis, Xiangmei Li, Xing Shen, Zhenlin Xu, Hongtao Lei. (2022) Broad-specific immunochromatography for simultaneous detection of various sulfonylureas in adulterated multi-herbal tea. FOOD CHEMISTRY, 370 (131055). [PMID:34536782] [10.1016/j.foodchem.2021.131055] |