Tolbutamide - ≥99%, high purity , Sulfonylurea receptor 1, Kir6.2 blocker, CAS No.64-77-7, Sulfonylurea receptor 1, Kir6.2 blocker

Item Number

T129578

• Synonyms: NSC 23813 | Orinase | Tolylsulfonylbutylurea | CAS-64-77-7 | tolbutamide | U 2043 | 3-butyl-1-(4-methylbenzenesulfonyl)urea | DTXCID801359 | N-4-Methylbenzolsulfonyl-N-butylurea | SMR000058363 | Tolbutamida | Tolbutamidum [INN-Latin] | 1-p-Toluenesulfonyl
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Blocker of ATP-sensitive (KIR6.x) inward rectifier K + channels.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: BLOCKER, CHANNEL BLOCKER, INHIBITOR
• Mechanism of action: Sulfonylurea receptor 1, Kir6.2 blocker
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Tolbutamide is a sulfonylurea agonist for secretion of insulin by beta-cells. In rat pancreatic beta-cells cultured in the presence of Tolbutamide displayed increased numbers of beta-cells in a dose responsive manner with beta-cell numbers doubling at 100 μg/ml of Tolbutamide. The compound displayed inhibitory action towards beta-cells at concentrations greater than 100 μg/ml. In addition in the presence of low glucose concentrations Tolbutamide’s cytotrophic action was inhibited. On isolated dog pancreas islets Tolbutamide at 180 μM stimulated the release of somatostatin, insulin and Glukagon in the absence of glucose. in all situations the loss of Ca2+ eliminated all effects of Tolbutamide. The compound has been observed to mechanistically enhance the secretion of insulin by highly selective amplification of insulin secretory burst mass.