Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T129337-1g | 1g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $77.90 | |
T129337-5g | 5g | In stock | $351.90 | |
T129337-25g | 25g | In stock | $1,579.90 | |
T129337-100g | 100g | In stock | $5,686.90 |
Non steroidal anti-inflammatory agent
Synonyms | TOLFENAMIC ACID [WHO-DD] | NCGC00016705-06 | NCGC00016705-10 | Tolfenamic acid (JAN/INN) | TOLFENAMIC ACID [EP MONOGRAPH] | 2-[(3-Chloro-2-methylphenyl)amino]benzoic Acid | Acide tolfenamique [INN-French] | EINECS 237-264-3 | HMS3370A02 | SY052546 | SPECT |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Tolfenamic Acid is non steroidal anti-inflammatory agent found to inhibit COX-2 isoenzymes in dogs. Its analgesic property is due to activation of Ca2+-activated K+ channels.Non steroidal anti-inflammatory agent. COX-2 inhibitor. Inhibits proliferation (I |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of AKR1C3 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-(3-chloro-2-methylanilino)benzoic acid |
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INCHI | InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18) |
InChi Key | YEZNLOUZAIOMLT-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O |
Isomeric SMILES | CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O |
WGK Germany | 3 |
RTECS | CB2687500 |
PubChem CID | 610479 |
Molecular Weight | 261.7 |
Reaxy-Rn | 657821 |
PubChem CID | 610479 |
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CAS Registry No. | 13710-19-5 |
ChEMBL Ligand | CHEMBL121626 |
Wikipedia | Tolfenamic acid |
RCSB PDB Ligand | TLF |
PEP | tolfenamic acid |
DrugCentral Ligand | 2698 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
H2211562 | Certificate of Analysis | May 08, 2024 | T129337 |
H2211563 | Certificate of Analysis | May 08, 2024 | T129337 |
H2211564 | Certificate of Analysis | May 08, 2024 | T129337 |
F2119022 | Certificate of Analysis | Apr 12, 2023 | T129337 |
F2117271 | Certificate of Analysis | Apr 11, 2023 | T129337 |
F2117272 | Certificate of Analysis | Apr 11, 2023 | T129337 |
F2017065 | Certificate of Analysis | Apr 25, 2022 | T129337 |
Solubility | Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25 °C), methanol (~10 mg/ml), and ethanol (slightly). |
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Melt Point(°C) | 209-214°C |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | CB2687500 |
Reaxy-Rn | 657821 |
Merck Index | 9513 |
1. Guanqiong Na, Xiaofei Hu, Yaning Sun, Guangxu Xing, Yunrui Xing, Gaiping Zhang. (2020) A novel gold particle-based paper sensor for sensitively detecting carprofen in bovine muscle. FOOD AND AGRICULTURAL IMMUNOLOGY, 31 (1): (463-474). [PMID:] [10.1080/09540105.2020.1740178] |
2. Xinyi Wang, Shijie Xu, Lina Jia, Yujia Yang, Yu Liu, Junbo Gong, Songgu Wu. (2019) Drug–drug salts of mefenamic acid\tolfenamic acid and piperazine to improve physicochemical properties for potential veterinary use. CRYSTENGCOMM, 21 (35): (5284-5291). [PMID:] [10.1039/C9CE00781D] |
3. Xue Shu-Wen, Li Jing, Xu Li. (2017) Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409 (12): (3103-3113). [PMID:28224244] [10.1007/s00216-017-0251-8] |
4. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo. (2015) Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs. MICROCHIMICA ACTA, 182 (15): (2585-2591). [PMID:] [10.1007/s00604-015-1638-x] |
5. Chaonan Huang,Yun Li,Jiajia Yang,Junyu Peng,Jun Tan,Yun Fan,Longxing Wang,Jiping Chen. (2018-09-03) Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine.. Talanta, 190 (15-22). [PMID:30172492] |
1. Pentikäinen PJ, Neuvonen PJ, Backman C. (1981) Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent.. Eur J Clin Pharmacol, 19 (5): (359-65). [PMID:7238564] [10.1021/op500134e] |
2. Guanqiong Na, Xiaofei Hu, Yaning Sun, Guangxu Xing, Yunrui Xing, Gaiping Zhang. (2020) A novel gold particle-based paper sensor for sensitively detecting carprofen in bovine muscle. FOOD AND AGRICULTURAL IMMUNOLOGY, 31 (1): (463-474). [PMID:] [10.1080/09540105.2020.1740178] |
3. Xinyi Wang, Shijie Xu, Lina Jia, Yujia Yang, Yu Liu, Junbo Gong, Songgu Wu. (2019) Drug–drug salts of mefenamic acid\tolfenamic acid and piperazine to improve physicochemical properties for potential veterinary use. CRYSTENGCOMM, 21 (35): (5284-5291). [PMID:] [10.1039/C9CE00781D] |
4. Xue Shu-Wen, Li Jing, Xu Li. (2017) Preparation of magnetic melamine-formaldehyde resin and its application to extract nonsteroidal anti-inflammatory drugs. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 409 (12): (3103-3113). [PMID:28224244] [10.1007/s00216-017-0251-8] |
5. Luo Zhi-yuan, Li Zhi-yong, Liu Hai-yan, Tang Min-qiong, Shi Zhi-guo. (2015) Click chemistry-based synthesis of water-dispersible hydrophobic magnetic nanoparticles for use in solid phase extraction of non-steroidal anti-inflammatory drugs. MICROCHIMICA ACTA, 182 (15): (2585-2591). [PMID:] [10.1007/s00604-015-1638-x] |
6. Chaonan Huang,Yun Li,Jiajia Yang,Junyu Peng,Jun Tan,Yun Fan,Longxing Wang,Jiping Chen. (2018-09-03) Hyperbranched mixed-mode anion-exchange polymeric sorbent for highly selective extraction of nine acidic non-steroidal anti-inflammatory drugs from human urine.. Talanta, 190 (15-22). [PMID:30172492] |