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Tolrestat - ≥98%, high purity , Aldose reductase inhibitor, CAS No.82964-04-3, Aldose reductase inhibitor

Specifications & Purity:  ≥98%
Item Number
T304733
Grouped product items
SKUSizeAvailabilityPrice Qty
T304733-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$112.90
T304733-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$187.90
T304733-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$423.90
T304733-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$652.90
T304733-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,038.90
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View related series
aldo-keto reductase family 1 member B Inhibitor

Basic Description

SynonymsTOLRESTAT|82964-04-3|Alredase|Lorestat|Tolrestatin|AY-27773|Tolrestatum|AY-27,773|AY 27773|2-(6-Methoxy-N-methyl-5-(trifluoromethyl)naphthalene-1-carbothioamido)acetic acid|CHEMBL436|0T93LG5NMK|CHEBI:48549|N-(6-methoxy-5-(trifluoromethyl)naphthalene-1-car
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeINHIBITOR
Mechanism of actionAldose reductase inhibitor

Product Properties

ALogP3.7

Associated Targets

AKR1B10 Tchem Aldo-keto reductase family 1 member B10 4 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 9 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1A1 Tchem Alcohol dehydrogenase [NADP(+)] 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid
INCHI InChI=1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
InChi Key LUBHDINQXIHVLS-UHFFFAOYSA-N
Canonical SMILES CN(CC(=O)O)C(=S)C1=CC=CC2=C1C=CC(=C2C(F)(F)F)OC
Isomeric SMILES CN(CC(=O)O)C(=S)C1=CC=CC2=C1C=CC(=C2C(F)(F)F)OC
PubChem CID 53359
Molecular Weight 357.35

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO: 20 mg/mL, clear

Related Documents

 SDS

 Specification Sheet

References

1. Srivastava SK, Ramana KV, Bhatnagar A.  (2005)  Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options..  Endocr Rev,  26  (3): (380-92).  [PMID:15814847]
2. Sestanj K, Bellini F, Fung S, Abraham N, Treasurywala A, Humber L, Simard-Duquesne N, Dvornik D.  (1984)  N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor..  J Med Chem,  27  (3): (255-6).  [PMID:6422042]

Solution Calculators

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