Grouped product items

SKU

Size

Availability

Price

Qty

T614503-5mg

5mg

Available within 8-12 weeks(?)

$930.90

T614503-25mg

25mg

Available within 8-12 weeks(?)

$3,260.90

Basic Description

Synonyms	1654W9611T \| R 1558 \| CS 023 \| BDBM50385714 \| (1r,5s,6s)-6-[(1r)-1-hydroxyethyl]-1-methyl-2-[(2s,4s)-2-[(3s)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1-methylpyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylic acid \| TOMOPENEM [WHO-DD] \| (4R,5S,6S
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(Human)

Homo sapiens (32628 Activities)

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Associated Targets(non-human)

Fusobacterium sp. (55 Activities)

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Eggerthella lenta (139 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Bacteroides fragilis (1445 Activities)

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Bacteroides thetaiotaomicron (562 Activities)

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Parabacteroides distasonis (282 Activities)

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Porphyromonas gingivalis (651 Activities)

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Fusobacterium mortiferum (179 Activities)

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Fusobacterium varium (184 Activities)

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Fusobacterium necrophorum (183 Activities)

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Peptoniphilus asaccharolyticus (368 Activities)

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Peptostreptococcus anaerobius (347 Activities)

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Staphylococcus aureus (210822 Activities)

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Escherichia coli (133304 Activities)

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Bacteroides uniformis (255 Activities)

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Phocaeicola vulgatus (440 Activities)

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Fusobacterium nucleatum (386 Activities)

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Finegoldia magna (323 Activities)

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Clostridioides difficile (2968 Activities)

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Clostridium perfringens (1165 Activities)

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Clostridium septicum (114 Activities)

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Thomasclavelia ramosa (78 Activities)

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Lactiplantibacillus plantarum (102 Activities)

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Paeniclostridium sordellii (66 Activities)

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Lacticaseibacillus casei (578 Activities)

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Limosilactobacillus fermentum (53 Activities)

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Eubacterium limosum (41 Activities)

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Cutibacterium acnes (887 Activities)

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Canis familiaris (36305 Activities)

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Rattus norvegicus (775804 Activities)

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Bacteroides ovatus (282 Activities)

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Prevotella bivia (313 Activities)

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Prevotella buccae (219 Activities)

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Prevotella melaninogenica (262 Activities)

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Hoylesella oralis (105 Activities)

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Veillonella parvula (45 Activities)

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Anaerococcus prevotii (218 Activities)

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Parvimonas micra (315 Activities)

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Rhesus monkey (3147 Activities)

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Capnocytophaga ochracea (15 Activities)

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Prevotella intermedia (369 Activities)

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Streptococcus constellatus (189 Activities)

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Plasma (328 Activities)

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Serum (58 Activities)

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mecA MecA (155 Activities)

Discover Target: mecA

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Bacteroides caccae (261 Activities)

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Bacteroides stercoris (113 Activities)

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Enterocloster clostridioformis (80 Activities)

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Porphyromonas asaccharolytica (102 Activities)

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Prevotella corporis (100 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(4R,5S,6S)-3-[(3S,5S)-5-[(3S)-3-[[2-(diaminomethylideneamino)acetyl]amino]pyrrolidine-1-carbonyl]-1-methylpyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
INCHI	InChI=1S/C23H35N7O6S/c1-10-17-16(11(2)31)21(34)30(17)18(22(35)36)19(10)37-13-6-14(28(3)9-13)20(33)29-5-4-12(8-29)27-15(32)7-26-23(24)25/h10-14,16-17,31H,4-9H2,1-3H3,(H,27,32)(H,35,36)(H4,24,25,26)/t10-,11-,12+,13+,14+,16-,17-/m1/s1
InChi Key	KEDAXBWZURNCHS-GPODMPQUSA-N
Canonical SMILES	CC1C2C(C(=O)N2C(=C1SC3CC(N(C3)C)C(=O)N4CCC(C4)NC(=O)CN=C(N)N)C(=O)O)C(C)O
Isomeric SMILES	C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](N(C3)C)C(=O)N4CC[C@@H](C4)NC(=O)CN=C(N)N)C(=O)O)[C@@H](C)O
Alternate CAS	222400-20-6
PubChem CID	9809656
MeSH Entry Terms	CS 023;CS-023;CS023 cpd;R 115685;R-115685;R115685;RO4908463;tomopenem

Database links

CAS Registry No.	222400-20-6
PubChem CID	9809656
ChEMBL Ligand	CHEMBL389847
Antibiotic DB	321

Certificates

Certificate of Analysis(COA)

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References

1. Shibayama T, Matsushita Y, Hirota T, Ikeda T, Kuwahara S. (2006) Pharmacokinetics of CS-023 (RO4908463), a novel parenteral carbapenem, in healthy male Caucasian volunteers.. Antimicrob Agents Chemother, 50 (12): (4186-8). [PMID:17043123] [10.1021/op500134e]
2. Koga T, Sugihara C, Kakuta M, Masuda N, Namba E, Fukuoka T. (2009) Affinity of Tomopenem (CS-023) for penicillin-binding proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.. Antimicrob Agents Chemother, 53 (3): (1238-41). [PMID:19104025] [10.1021/op500134e]
3. Thomson KS, Moland ES. (2004) CS-023 (R-115685), a novel carbapenem with enhanced in vitro activity against oxacillin-resistant staphylococci and Pseudomonas aeruginosa.. J Antimicrob Chemother, 54 (2): (557-62). [PMID:15201229] [10.1021/op500134e]
4. Koga T, Abe T, Inoue H, Takenouchi T, Kitayama A, Yoshida T, Masuda N, Sugihara C, Kakuta M, Nakagawa M et al.. (2005) In vitro and in vivo antibacterial activities of CS-023 (RO4908463), a novel parenteral carbapenem.. Antimicrob Agents Chemother, 49 (8): (3239-50). [PMID:16048932] [10.1021/op500134e]
5. Tanaka K, Mikamo H, Nakao K, Ichiishi T, Goto T, Yamagishi Y, Watanabe K. (2009) In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria.. Antimicrob Agents Chemother, 53 (1): (319-22). [PMID:18955522] [10.1021/op500134e]

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tomopenem , CAS No.222400-20-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price	Qty
T614503-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$930.90
T614503-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,260.90