Topiramate - 98%, high purity , Sodium channel alpha subunit blocker, CAS No.97240-79-4, Sodium channel alpha subunit blocker

Item Number

T115813

• Synonyms: McN 4853 | RWJ 17021 | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate | Epitoma | HMS2232H21 | [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]me
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: GluR5 kainate receptor antagonist (IC 50 = 0.46 μM). inhibitor. Positive allosteric GABA A modulator. Inhibits L-type Ca 2+ and Na V channels (IC 50 = 49 μM). Inhibits carbonic anhydrase (K i values are 0.1 and 0.2 μM at CA II and CA IV, respectively).
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Sodium channel alpha subunit blocker
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Kainate GluR5 receptor antagonist; anticonvulsant.