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Topiroxostat - 98%, high purity , Xanthine dehydrogenase inhibitor, CAS No.577778-58-6, Xanthine dehydrogenase inhibitor

Moligand™

≥98%

CAS#: 577778-58-6
Formula: C₁₃H₈N₆
Molecular Weight: 248.24
PubChem CID: 5288320

Item Number

T304047

Grouped product items
SKU	Size	Availability	Price
T304047-1g	1g	In stock	$103.90
T304047-5g	5g	In stock	$412.90
T304047-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,648.90

View related series

xanthine dehydrogenase Inhibitor

Basic Description

Synonyms	4-(5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl)picolinonitrile \| 2-Pyridinecarbonitrile, 4-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]- \| AKOS026750465 \| UBVZQGOVTLIHLH-UHFFFAOYSA-N \| FYX 051 \| GTPL10592 \| 4-[5-PYRIDIN-4-YL-1H-[1,2,4]TRIAZOL-3-YL]-PYRIDINE-2-CARBO
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Xanthine dehydrogenase inhibitor
Product Description	Topiroxostat is a xanthine oxidoreductase (XOR) inhibitor。Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%).

Associated Targets(Human)

XDH Tclin Xanthine dehydrogenase/oxidase (1 Activities)

Discover Target: XDH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

XDH Tclin Xanthine dehydrogenase (1038 Activities)

Discover Target: XDH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)

Discover Target: ABCG2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-(5-pyridin-4-yl-1H-1,2,4-triazol-3-yl)pyridine-2-carbonitrile
INCHI	InChI=1S/C13H8N6/c14-8-11-7-10(3-6-16-11)13-17-12(18-19-13)9-1-4-15-5-2-9/h1-7H,(H,17,18,19)
InChi Key	UBVZQGOVTLIHLH-UHFFFAOYSA-N
Canonical SMILES	C1=CN=CC=C1C2=NC(=NN2)C3=CC(=NC=C3)C#N
Isomeric SMILES	C1=CN=CC=C1C2=NC(=NN2)C3=CC(=NC=C3)C#N
Alternate CAS	577778-58-6
PubChem CID	5288320
MeSH Entry Terms	4-(5-pyridin-4-yl-1H-(1,2,4) triazol-3-yl)pyridine-2-carbonitrile;FYX-051;topiroxostat
Molecular Weight	248.24

CAS Registry No.

PubChem CID

RCSB PDB Ligand

DrugCentral Ligand

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
H2104409	Certificate of Analysis	May 13, 2024	T304047
H2104411	Certificate of Analysis	May 13, 2024	T304047
H2104412	Certificate of Analysis	May 13, 2024	T304047

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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