Topotecan hydrochloride - 98%, high purity , DNA topoisomerase I, mitochondrial inhibitor, CAS No.119413-54-6, DNA topoisomerase I, mitochondrial inhibitor

Item Number

T294611

• Synonyms: AMY24931 | NCGC00095189-01 | NSC759263 | NSC-759263 | Pharmakon1600-01505820 | Hydrochloride, Nogitecan | NC00177 | 1H-Pyrano[3',7]indolizino[1,2-b]quinoline- 3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)-
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Topoisomerase I inhibitor. Water-soluble derivative of camptothecin. Anticancer agent.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Action Type: INHIBITOR
• Mechanism of action: DNA topoisomerase I, mitochondrial inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Topotecan HCl (NSC609699, Nogitecan, SKFS 104864A) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.