Topotecan hydrochloride - 98%, high purity , DNA topoisomerase I, mitochondrial inhibitor, CAS No.119413-54-6, DNA topoisomerase I, mitochondrial inhibitor

Item Number

T294611

Grouped product items
SKU	Size	Availability	Price
T294611-50mg	50mg	In stock	$134.90
T294611-250mg	250mg	In stock	$607.90
T294611-1g	1g	In stock	$2,187.90

Topoisomerase inhibitor

Basic Description

Synonyms	TOPOTECAN HYDROCHLORIDE\|119413-54-6\|Topotecan Hcl\|Hycamtin\|Nogitecan hydrochloride\|Topotecan (Hydrochloride)\|Topotecan monohydrochloride\|Evotopin\|Topotecan teva\|Topotecan Hospira\|SK&F S-104864-A\|Hycamptamine hydrochloride\|potactasol\|Topotecan hydrochlorid
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	DNA topoisomerase I, mitochondrial inhibitor
Product Description	Topotecan HCl (NSC609699, Nogitecan, SKFS 104864A) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis.

Names and Identifiers

Pubchem Sid	488183404
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488183404
IUPAC Name	(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione;hydrochloride
INCHI	InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1
InChi Key	DGHHQBMTXTWTJV-BQAIUKQQSA-N
Canonical SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl
Isomeric SMILES	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O.Cl
PubChem CID	60699
Molecular Weight	457.91

Certificates

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

15 results found

Lot Number	Certificate Type	Date	Item
I2301662	Certificate of Analysis	Jul 31, 2023	T294611
I2301665	Certificate of Analysis	Jul 31, 2023	T294611
I2301674	Certificate of Analysis	Jul 31, 2023	T294611
K2224910	Certificate of Analysis	Dec 05, 2022	T294611
K2224918	Certificate of Analysis	Dec 05, 2022	T294611
K2224933	Certificate of Analysis	Dec 05, 2022	T294611
C23241187	Certificate of Analysis	Nov 23, 2022	T294611
C23241188	Certificate of Analysis	Nov 23, 2022	T294611
C23241189	Certificate of Analysis	Nov 23, 2022	T294611
C23241203	Certificate of Analysis	Nov 23, 2022	T294611
C23241247	Certificate of Analysis	Nov 23, 2022	T294611
K2004200	Certificate of Analysis	Aug 12, 2022	T294611
K2004199	Certificate of Analysis	Aug 12, 2022	T294611
K2004198	Certificate of Analysis	Aug 12, 2022	T294611
H2201094	Certificate of Analysis	Aug 05, 2022	T294611

Sensitivity

Light sensitive

Melt Point(°C)

213-225°C

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description