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Tosedostat (CHR2797) - ≥95%, high purity , Aminopeptidase inhibitor, CAS No.238750-77-1, Aminopeptidase inhibitor

≥95%

CAS#: 238750-77-1
Formula: C₂₁H₃₀N₂O₆
Molecular Weight: 406.47
PubChem CID: 15547703

Item Number

T129884

Grouped product items
SKU	Size	Availability	Price
T129884-5mg	5mg	In stock	$162.90
T129884-10mg	10mg	In stock	$260.90
T129884-25mg	25mg	In stock	$532.90
T129884-50mg	50mg	In stock	$870.90
T129884-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,578.90
T129884-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$3,552.90

Aminopeptidase inhibitor

Basic Description

Synonyms	CHR-2797(Tosedostat) \| Tosedostat \| BCP9000524 \| AC-375 \| BENZENEACETIC ACID, .ALPHA.-(((2R)-2-((1S)-1-HYDROXY-2-(HYDROXYAMINO)-2-OXOETHYL)-4- METHYL-1-OXOPENTY)LAMINO)-, CYCLOPENTYL ESTER, (.ALPHA.S)- \| Tosedostat [USAN:INN] \| (5S,8S)-8-({(1R)-1-[3,5-bis
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	Aminopeptidase inhibitor (IC50values are 100, 150, 220, > 1000, > 5000, > 10000 and > 30000 nM for LAP, PuSA, aminopeptidase N, aminopeptidase B, PILSAP, LTA4hydrolase and MetAP2, respectively). Potently inhibits tumor cell proliferation in a variety of
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Aminopeptidase inhibitor

Associated Targets(Human)

NPEPPS Tchem Puromycin-sensitive aminopeptidase (1 Activities)

Discover Target: NPEPPS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (1 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ANPEP Tchem Aminopeptidase N (1 Activities)

Discover Target: ANPEP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ANPEP Tchem Aminopeptidase N (863 Activities)

Discover Target: ANPEP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

Discover Target: MMP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NPEPPS Tchem Puromycin-sensitive aminopeptidase (33 Activities)

Discover Target: NPEPPS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP7 Tchem Matrix metalloproteinase 7 (1073 Activities)

Discover Target: MMP7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HL-60 (67320 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MOLT-4 (49676 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mmp13 Matrix metalloproteinase 13 (19 Activities)

Discover Target: Mmp13

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Discover Target: Mmp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	cyclopentyl (2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate
INCHI	InChI=1S/C21H30N2O6/c1-13(2)12-16(18(24)20(26)23-28)19(25)22-17(14-8-4-3-5-9-14)21(27)29-15-10-6-7-11-15/h3-5,8-9,13,15-18,24,28H,6-7,10-12H2,1-2H3,(H,22,25)(H,23,26)/t16-,17+,18+/m1/s1
InChi Key	FWFGIHPGRQZWIW-SQNIBIBYSA-N
Canonical SMILES	CC(C)CC(C(C(=O)NO)O)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2
Isomeric SMILES	CC(C)C[C@H]([C@@H](C(=O)NO)O)C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC2CCCC2
PubChem CID	15547703
Molecular Weight	406.47

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
B2219159	Certificate of Analysis	Dec 21, 2023	T129884
B2219160	Certificate of Analysis	Dec 21, 2023	T129884
C2209187	Certificate of Analysis	Dec 21, 2023	T129884
C2209193	Certificate of Analysis	Dec 21, 2023	T129884
C2209195	Certificate of Analysis	Dec 21, 2023	T129884
C2209196	Certificate of Analysis	Dec 21, 2023	T129884

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Tosedostat (CHR2797) - ≥95%, high purity , Aminopeptidase inhibitor, CAS No.238750-77-1, Aminopeptidase inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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