TPCA-1 - ≥98%, high purity , CAS No.507475-17-4, Inhibitor of inhibitor of nuclear factor kappa B kinase subunit beta

Item Number

T126861

• Synonyms: SMR001834876 | 2-{2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid | BCP05956 | Pinitol TMS | SW218246-2 | 3-thiophenecarboxamide,2-((aminocarbonyl)amino)-5-(4-fluorophenyl)- | 5-(4-fluorophenyl)-2-ureido-thiophene-3 carboxylic acid amide | H
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: TPCA-1 is potent, selective inhibitor of IκB kinase-2 (IKK-2) (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines i
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of inhibitor of nuclear factor kappa B kinase subunit beta
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

TPCA-1 is potent, selective inhibitor of IKK-2 (IC50 = 17.9 nM) that displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes.
A potent inhibitor of IKKβ (IKK-2)