Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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T276217-5mg | 5mg | In stock | $27.90 | |
T276217-25mg | 25mg | In stock | $112.90 | |
T276217-100mg | 100mg | In stock | $375.90 | |
T276217-250mg | 250mg | In stock | $846.90 | |
T276217-500mg | 500mg | In stock | $1,522.90 |
Potent angiotensin-converting enzyme (ACE) inhibitor
Synonyms | D00383 | SR-02000000917 | Tox21_113152 | 1H-Indole-2-carboxylic acid, 1-((2S)-2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-, (2S,3aR,7aS)- | BDBM50369775 | Gopten | STK802586 | Trandolaprilum (Latin) | 1-(2-((1-(ethoxycarbonyl)-3-phe |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Potent angiotensin-converting enzyme (ACE) inhibitor (IC 50 = 2.5 nM). Prevents the conversion of angiotensin I into angiotensin II. Potent vasoconstrictor. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Angiotensin-converting enzyme inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product description: Trandolapril (RU44570) is a nonsulfhydryl prodrug that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI). |
ALogP | 2 |
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IUPAC Name | (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid |
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INCHI | InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1 |
InChi Key | VXFJYXUZANRPDJ-WTNASJBWSA-N |
Canonical SMILES | CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(=O)O |
Isomeric SMILES | CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@@H]3C[C@H]2C(=O)O |
PubChem CID | 5484727 |
Molecular Weight | 430.55 |
PubChem CID | 5484727 |
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ChEMBL Ligand | CHEMBL1519 |
Wikipedia | Trandolapril |
CAS Registry No. | 87679-37-6 |
DrugBank Ligand | DB00519 |
PEP | trandolapril |
Reactome Reaction | R-HSA-9619024 |
Reactome Drug | R-ALL-9619015 |
DrugCentral Ligand | 2712, 2712 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I22081019 | Certificate of Analysis | Jun 15, 2023 | T276217 |
I22081021 | Certificate of Analysis | Jun 15, 2023 | T276217 |
I22081030 | Certificate of Analysis | Jun 15, 2023 | T276217 |
I22081031 | Certificate of Analysis | Jun 15, 2023 | T276217 |
I22081039 | Certificate of Analysis | Jun 15, 2023 | T276217 |
Solubility | Soluble in DMSO and ethanol |
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Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H373:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |