Grouped product items

SKU

Size

Availability

Price

Qty

R132818-100mg

100mg

Available within 8-12 weeks(?)

$34.90

R132818-250mg

250mg

In stock

$68.90

R132818-500mg

500mg

Available within 8-12 weeks(?)

$156.90

R132818-1g

In stock

$248.90

R132818-5g

In stock

$1,117.90

Basic Description

Synonyms	(1R,2S)-2-phenylcyclopropan-1-amine;hydrochloride \| Tox21_110514_1 \| MFCD17976456 \| MLS001335868 \| HB1412 \| SKF-385 HCl \| A902849 \| trans-2-phenylcyclopropan-1-amine hydrochloride \| (1R,2S)-tranylcypromine hydrochloride \| CHEBI:131514 \| SCHEMBL56351 \| L-t
Specifications & Purity	≥97%
Biochemical and Physiological Mechanisms	Non-selective MAO-A/B inhibitor.Irreversible monoamine oxidase (MAO) inhibitor. Increases serotonergic, noradrenergic activity and augments dopamine transmission. Additionally inhibits LSD1 (BHC110), inhibiting histone demethylation (IC 50 = >50 μM). Anti
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	trans-2-Phenylcyclopropylamine hydrochloride is a non-selective MAO-A/B inhibitor. trans- 2-Phenylcyclopropylamine Hydrochloride is an inhibitor of LSD1. LSD1 specifically demethylates lysine on histones. A non-selective inhibitor of MAO

Associated Targets(Human)

MAOA Tclin Monoamine oxidase A (11911 Activities)

Discover Target: MAOA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOB Tclin Monoamine oxidase B (8835 Activities)

Discover Target: MAOB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LNCaP (8286 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)

Discover Target: KDM1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4C Tchem Lysine-specific demethylase 4C (1129 Activities)

Discover Target: KDM4C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM1B Tbio Lysine-specific histone demethylase 1B (147 Activities)

Discover Target: KDM1B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM3A Tchem Lysine-specific demethylase 3A (116 Activities)

Discover Target: KDM3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM2A Tchem Lysine-specific demethylase 2A (198 Activities)

Discover Target: KDM2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM6B Tchem Lysine-specific demethylase 6B (280 Activities)

Discover Target: KDM6B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM5C Tchem Lysine-specific demethylase 5C (224 Activities)

Discover Target: KDM5C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Taar1 Trace amine-associated receptor 1 (899 Activities)

Discover Target: Taar1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(1R,2S)-2-phenylcyclopropan-1-amine;hydrochloride
INCHI	InChI=1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1
InChi Key	ZPEFMSTTZXJOTM-OULXEKPRSA-N
Canonical SMILES	C1C(C1N)C2=CC=CC=C2.Cl
Isomeric SMILES	C1[C@H]([C@@H]1N)C2=CC=CC=C2.Cl
WGK Germany	3
PubChem CID	2723716
Molecular Weight	169.65

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
B2423033	Certificate of Analysis	Mar 01, 2024	R132818
L2106718	Certificate of Analysis	Sep 19, 2023	R132818
L2106731	Certificate of Analysis	Sep 19, 2023	R132818
F1505095	Certificate of Analysis	Jan 25, 2023	R132818

Chemical and Physical Properties

Solubility	Soluble in water (100 mM), methanol, DMSO (50 mg/ml), ethanol, and ethyl acetate.
Specific Rotation[α]	[α]/D −1 to +1.0°, c = 1 in H2O
Melt Point(°C)	162-169 °C (lit.)

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3

References

1. Therese Ericsson,Jesper Sundell,Angelica Torkelsson,Kurt-Jürgen Hoffmann,Michael Ashton. (2014-01-10) Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.. Xenobiotica; the fate of foreign compounds in biological systems, 44 ((7)): (615-626). [PMID:24400699]
2. Robert Haberzettl,Heidrun Fink,Bettina Bert. (2014-05-02) The murine serotonin syndrome - evaluation of responses to 5-HT-enhancing drugs in NMRI mice.. Behavioural brain research, 277 (204-210). [PMID:24780865]
3. Christine R Klaus,Dorothy Iwanowicz,Danielle Johnston,Carly A Campbell,Jesse J Smith,Mikel P Moyer,Robert A Copeland,Edward J Olhava,Margaret Porter Scott,Roy M Pollock,Scott R Daigle,Alejandra Raimondi. (2014-07-06) DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.. The Journal of pharmacology and experimental therapeutics, 350 ((3)): (646-656). [PMID:24993360]
4. Julia Dinger,Markus R Meyer,Hans H Maurer. (2014-08-12) Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse.. Toxicology letters, 230 ((1)): (28-35). [PMID:25111188]
5. Susanna Tse,Louis Leung,Sangeeta Raje,Mark Seymour,Yoko Shishikura,R Scott Obach. (2014-09-14) Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry.. Drug metabolism and disposition: the biological fate of chemicals, 42 ((12)): (2023-2032). [PMID:25217486]
6. Yuki Ogawa,Mitsuru Irikura,Yuka Kobaru,Mayu Tomiyasu,Yoshie Kochiyama,Mamiko Uriu,Yoichi Ishitsuka,Yuki Kondo,Eiji Yukawa,Noboru Kamada,Hitoshi Ohno,Toshio Yamazaki,Tetsumi Irie. (2014-09-25) Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea.. European journal of pediatrics, 174 ((4)): (509-518). [PMID:25248340]
7. Ramakrishna Nirogi,Raghava Choudary Palacharla,Abdul Rasheed Mohammed,Arunkumar Manoharan,Ranjith Kumar Ponnamaneni,Gopinadh Bhyrapuneni. (2015-02-07) Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.. Chemico-biological interactions, 230 (9-20). [PMID:25656918]
8. Peng Han,Dehong Gao,Wei Zhang,Suhuan Liu,Shuyu Yang,Xuejun Li. (2015-03-31) Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells.. Life sciences, 130 (103-107). [PMID:25817234]
9. Sarah J Morse,Anderson A Butler,Robin L Davis,Ian J Soller,Farah D Lubin. (2015-04-04) Environmental enrichment reverses histone methylation changes in the aged hippocampus and restores age-related memory deficits.. Biology, 4 ((2)): (298-313). [PMID:25836028]
10. Jennifer L Goldman,J Steven Leeder,Leon Van Haandel,Robin E Pearce. (2015-07-04) In Vitro Hepatic Oxidative Biotransformation of Trimethoprim.. Drug metabolism and disposition: the biological fate of chemicals, 43 ((9)): (1372-1380). [PMID:26138612]
11. Kaisa A Salminen,Minna Rahnasto-Rilla,Raija Väänänen,Peter Imming,Achim Meyer,Aline Horling,Antti Poso,Tuomo Laitinen,Hannu Raunio,Maija Lahtela-Kakkonen. (2015-09-25) Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis.. Drug metabolism and disposition: the biological fate of chemicals, 43 ((12)): (1891-1904). [PMID:26400396]
12. James M Hill,Debra C Quenelle,Rhonda D Cardin,Jodi L Vogel,Christian Clement,Fernando J Bravo,Timothy P Foster,Marta Bosch-Marce,Priya Raja,Jennifer S Lee,David I Bernstein,Philip R Krause,David M Knipe,Thomas M Kristie. (2014-12-05) Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.. Science translational medicine, 6 ((265)): (265ra169-265ra169). [PMID:25473037]

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trans-2-Phenylcyclopropylamine hydrochloride - 97%, high purity , CAS No.1986-47-6

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
R132818-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$34.90
R132818-250mg	250mg	In stock	$68.90
R132818-500mg	500mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$156.90
R132818-1g	1g	In stock	$248.90
R132818-5g	5g	In stock	$1,117.90