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trans-2-Phenylcyclopropylamine hydrochloride - 97%, high purity , CAS No.1986-47-6

  • ≥97%
Item Number
R132818
Grouped product items
SKUSizeAvailabilityPrice Qty
R132818-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$34.90
R132818-250mg
250mg
In stock
$68.90
R132818-500mg
500mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$156.90
R132818-1g
1g
In stock
$248.90
R132818-5g
5g
In stock
$1,117.90
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Irreversible monoamine oxidase (MAO) inhibitor

Basic Description

Synonyms1986-47-6|Tranylcypromine hydrochloride|37388-05-9|trans-2-Phenylcyclopropylamine hydrochloride|trans-2-Phenylcyclopropanamine hydrochloride|(1R,2S)-2-phenyl-cyclopropylamine hydrochloride|(1R,2S)-2-Phenylcyclopropanamine hydrochloride|(1R,2S)-2-phenylcyc
Specifications & Purity97%
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

trans-2-Phenylcyclopropylamine hydrochloride is a non-selective MAO-A/B inhibitor. trans- 2-Phenylcyclopropylamine Hydrochloride is an inhibitor of LSD1. LSD1 specifically demethylates lysine on histones.
A non-selective inhibitor of MAO

Names and Identifiers

IUPAC Name (1R,2S)-2-phenylcyclopropan-1-amine;hydrochloride
INCHI InChI=1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m0./s1
InChi Key ZPEFMSTTZXJOTM-OULXEKPRSA-N
Canonical SMILES C1C(C1N)C2=CC=CC=C2.Cl
Isomeric SMILES C1[C@H]([C@@H]1N)C2=CC=CC=C2.Cl
WGK Germany 3
PubChem CID 2723716
Molecular Weight 169.65

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot NumberCertificate TypeDateItem
B2423033Certificate of AnalysisMar 01, 2024 R132818
L2106718Certificate of AnalysisSep 19, 2023 R132818
L2106731Certificate of AnalysisSep 19, 2023 R132818

Chemical and Physical Properties

SolubilitySoluble in water (100 mM), methanol, DMSO (50 mg/ml), ethanol, and ethyl acetate.
Specific Rotation[α][α]/D −1 to +1.0°, c = 1 in H2O
Melt Point(°C)162-169 °C (lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

References

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2. Robert Haberzettl,Heidrun Fink,Bettina Bert.  (2014-05-02)  The murine serotonin syndrome - evaluation of responses to 5-HT-enhancing drugs in NMRI mice..  Behavioural brain research,  277  (204-210).  [PMID:24780865]
3. Christine R Klaus,Dorothy Iwanowicz,Danielle Johnston,Carly A Campbell,Jesse J Smith,Mikel P Moyer,Robert A Copeland,Edward J Olhava,Margaret Porter Scott,Roy M Pollock,Scott R Daigle,Alejandra Raimondi.  (2014-07-06)  DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells..  The Journal of pharmacology and experimental therapeutics,  350  ((3)): (646-656).  [PMID:24993360]
4. Julia Dinger,Markus R Meyer,Hans H Maurer.  (2014-08-12)  Development of an in vitro cytochrome P450 cocktail inhibition assay for assessing the inhibition risk of drugs of abuse..  Toxicology letters,  230  ((1)): (28-35).  [PMID:25111188]
5. Susanna Tse,Louis Leung,Sangeeta Raje,Mark Seymour,Yoko Shishikura,R Scott Obach.  (2014-09-14)  Disposition and metabolic profiling of [(14)C]cerlapirdine using accelerator mass spectrometry..  Drug metabolism and disposition: the biological fate of chemicals,  42  ((12)): (2023-2032).  [PMID:25217486]
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7. Ramakrishna Nirogi,Raghava Choudary Palacharla,Abdul Rasheed Mohammed,Arunkumar Manoharan,Ranjith Kumar Ponnamaneni,Gopinadh Bhyrapuneni.  (2015-02-07)  Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction..  Chemico-biological interactions,  230  (9-20).  [PMID:25656918]
8. Peng Han,Dehong Gao,Wei Zhang,Suhuan Liu,Shuyu Yang,Xuejun Li.  (2015-03-31)  Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells..  Life sciences,  130  (103-107).  [PMID:25817234]
9. Sarah J Morse,Anderson A Butler,Robin L Davis,Ian J Soller,Farah D Lubin.  (2015-04-04)  Environmental enrichment reverses histone methylation changes in the aged hippocampus and restores age-related memory deficits..  Biology,  4  ((2)): (298-313).  [PMID:25836028]
10. Jennifer L Goldman,J Steven Leeder,Leon Van Haandel,Robin E Pearce.  (2015-07-04)  In Vitro Hepatic Oxidative Biotransformation of Trimethoprim..  Drug metabolism and disposition: the biological fate of chemicals,  43  ((9)): (1372-1380).  [PMID:26138612]
11. Kaisa A Salminen,Minna Rahnasto-Rilla,Raija Väänänen,Peter Imming,Achim Meyer,Aline Horling,Antti Poso,Tuomo Laitinen,Hannu Raunio,Maija Lahtela-Kakkonen.  (2015-09-25)  Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis..  Drug metabolism and disposition: the biological fate of chemicals,  43  ((12)): (1891-1904).  [PMID:26400396]
12. James M Hill,Debra C Quenelle,Rhonda D Cardin,Jodi L Vogel,Christian Clement,Fernando J Bravo,Timothy P Foster,Marta Bosch-Marce,Priya Raja,Jennifer S Lee,David I Bernstein,Philip R Krause,David M Knipe,Thomas M Kristie.  (2014-12-05)  Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes..  Science translational medicine,  6  ((265)): (265ra169-265ra169).  [PMID:25473037]

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