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trans-4-(Aminomethyl)cyclohexanecarboxylic acid - 98%, high purity , CAS No.1197-18-8
Antifibrinolytic and plasminogen activation inhibitor
Basic Description Synonyms tranexamic acid | AMCA | Cyklokapron Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Antifibrinolytic and plasminogen activation inhibitor. Blocks lysine-binding sites of plasmin and elastase-derived plasminogen fragments (IC 50 = 5 mM). Shipped In Normal Note 25g,50g卖完停产，不再备货.Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Inhibits plasmin-induced fibrinolysis
Associated Targets(Human) Names and Identifiers Pubchem Sid 488179908 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488179908 IUPAC Name 4-(aminomethyl)cyclohexane-1-carboxylic acid INCHI InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11) InChi Key GYDJEQRTZSCIOI-UHFFFAOYSA-N Canonical SMILES NC[C@H]1CC[C@@H](CC1)C(O)=O Isomeric SMILES C1CC(CCC1CN)C(=O)O WGK Germany 2 PubChem CID 5526 Molecular Weight 157.21
Chemical and Physical Properties Solubility Soluble in water (167 mg/ml), ethanol (<1 mg/ml at 25°C).Very slightly soluble in ether, DMSO (<1 mg/ml at 25°C), and alcohol.
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 2 Merck Index 9569
Citations of This Product 1. Qiao Yu, Baihai Su, Weifeng Zhao, Changsheng Zhao. (2022) Janus Self-Propelled Chitosan-Based Hydrogel Spheres for Rapid Bleeding Control. Advanced Science, 10 (5): (2205989). [PMID:36567271 ] [10.1002/advs.202205989 ] 2. Bitao Lu, Enling Hu, Ruiqi Xie, Kun Yu, Fei Lu, Rong Bao, Chenhui Wang, Guangqian Lan, Fangyin Dai. (2022) Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes. Bioactive Materials, 16 (372). [PMID:35415282 ] [10.1016/j.bioactmat.2022.01.002 ] 3. Guangxue Chen, Xiaoyuan Guan, Ruixin Xu, Junfei Tian, Fachuang Lu, Minghui He, Jianwen Yang. (2016) Thioxanthone dicarboxamide derivatives as one-component photoinitiators for near-UV and visible LED (365–405 nm) induced photopolymerizations. RSC Advances, 6 (80): (77093-77099). [PMID: [10.1039/C6RA13512A ]
References 1. Qiao Yu, Baihai Su, Weifeng Zhao, Changsheng Zhao. (2022) Janus Self-Propelled Chitosan-Based Hydrogel Spheres for Rapid Bleeding Control. Advanced Science, 10 (5): (2205989). [PMID:36567271 ] [10.1002/advs.202205989 ] 2. Bitao Lu, Enling Hu, Ruiqi Xie, Kun Yu, Fei Lu, Rong Bao, Chenhui Wang, Guangqian Lan, Fangyin Dai. (2022) Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes. Bioactive Materials, 16 (372). [PMID:35415282 ] [10.1016/j.bioactmat.2022.01.002 ] 3. Guangxue Chen, Xiaoyuan Guan, Ruixin Xu, Junfei Tian, Fachuang Lu, Minghui He, Jianwen Yang. (2016) Thioxanthone dicarboxamide derivatives as one-component photoinitiators for near-UV and visible LED (365–405 nm) induced photopolymerizations. RSC Advances, 6 (80): (77093-77099). [PMID: [10.1039/C6RA13512A ]
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